LUIZ APARECIDO BORTOLOTTO

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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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Autor: BORTOLOTTO, Luiz ×

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Agora exibindo 1 - 10 de 27
  • conferenceObject
    GENDER-RELATED DIFFERENCES IN CORONARY ARTERY DISEASE IN PATIENTS WITH RESISTANT HYPERTENSION
    (2022) SOLIMENE, Maria Cecilia; DRAGER, Luciano; BORTOLOTTO, Luiz
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    HDL FUNCTIONALITY MODULATES CAROTID ARTERY INTIMA-MEDIA THICKNESS IN INDIVIDUALS WITH MARKED HYPERALPHALIPOPROTEINEMIA
    (2016) LAURINAVICIUS, Antonio; ROCHA, Viviane; BORTOLOTTO, Luiz; SANTOS, Raul
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    GENDER-RELATED DIFFERENCES IN CORONARY ARTERY DISEASE IN PATIENTS WITH RESISTANT HYPERTENSION
    (2022) SOLIMENE, Maria Cecilia; DRAGER, Luciano; BORTOLOTTO, Luiz
  • article 6 Citação(ões) na Scopus
    Shortening telomere is associated with subclinical atherosclerosis biomarker in omnivorous but not in vegetarian healthy men
    (2019) CINEGAGLIA, Naiara; ANTONIAZZI, Luiza; ROSA, Daniela; MIRANDA, Debora; ACOSTA-NAVARRO, Julio; BORTOLOTTO, Luiz; HONG, Valeria; SANDRIM, Valeria
    Telomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none of them have evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukocyte telomere length (LTL) in vegetarians and omnivorous subjects and its association with classical cardiovascular risk biomarkers. From the total of 745 participants initially recruited, 44 omnivorous and 44 vegetarian men apparently healthy were selected for this study and LTL was measured in 39 omnivorous and 41 vegetarians by Real-Time Quantitative PCR reaction. Although telomere length was not different between omnivorous and vegetarians, we found a strong negative correlation between LTL and IMT (intima-media thickness) in omnivorous, but not in vegetarian group. In addition, omnivorous who were classified with short telomere length had higher carotid IMT compared to vegetarians. Our data suggest that telomere length can be a marker of subclinical atherosclerosis in the omnivorous group.
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    Reversion of Severe Cardiac and Renal Dysfunction With Surgical Correction of Atypical Aortic Coarctation in Adult Patient: Case Report
    (2018) BORTOLOTTO, Alexandre L.; FILHO, Rogerio B.; MOREIRA, Everton L.; DALLAN, Luis A.; BORTOLOTTO, Luiz
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    The Impact of Arterial Hypertension in Maternal and Perinatal Outcomes in Pregnancies With Takayasu Arteritis.
    (2018) BORTOLOTTO, Luiz; BORTOLOTTO, Maria R.; CODARIN, Rodrigo R.; GOMES, Tiago J.; TESTA, Carolina B.; FRANCISCO, Rossana P.; ZUGAIB, Marcelo
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    IMPACT OF PREVIOUS HYPERTENSIVE DISORDER DURING PREGNANCY ON ANTHROPOMETRIC MEASUREMENTS, 24-HOUR BLOOD PRESSURE AND ARTERIAL STIFFNESS
    (2021) VERARDINO, Renata; RODRIGUES, Sara; BERGER, Ana; COSTA-HONG, Valeria; MACEDO, Thiago; BAPTISTA, Fernanda; BORTOLOTTO, Maria; FRANCISCO, Rossana; ZUGAIB, Marcelo; BORTOLOTTO, Luiz
  • article 7 Citação(ões) na Scopus
    A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial
    (2011) FUCHS, Flavio D.; FUCHS, Sandra C.; MOREIRA, Leila B.; GUS, Miguel; NOBREGA, Antonio C.; POLI-DE-FIGUEIREDO, Carlos E.; MION, Decio; BORTOLOTTO, Luiz; CONSOLIM-COLOMBO, Fernanda; NOBRE, Fernando; COELHO, Eduardo Barbosa; VILELA-MARTIN, Jose F.; MORENO JR., Heitor; CESARINO, Evandro Jose; FRANCO, Roberto; BRANDAO, Andrea Araujo; SOUSA, Marcos R. de; RIBEIRO, Antonio Luiz Pinho; JARDIM, Paulo Cesar; AFIUNE NETO, Abrahao; SCALA, Luiz Cesar N.; MOTA, Marco; CHAVES, Hilton; ALVES, Joao Guilherme; SOBRAL FILHO, Dario C.; SILVA, Ricardo Pereira e; FIGUEIREDO NETO, Jose A.; IRIGOYEN, Maria Claudia; CASTRO, Iran; STEFFENS, Andre Avelino; SCHLATTER, Rosane; MELLO, Renato Bandeira de; MOSELE, Francisca; GHIZZONI, Flavia; BERWANGER, Otavio
    Background: Cardiovascular disease is the leading cause of death in Brazil, and hypertension is its major risk factor. The benefit of its drug treatment to prevent major cardiovascular events was consistently demonstrated. Angiotensin-receptor blockers (ARB) have been the preferential drugs in the management of hypertension worldwide, despite the absence of any consistent evidence of advantage over older agents, and the concern that they may be associated with lower renal protection and risk for cancer. Diuretics are as efficacious as other agents, are well tolerated, have longer duration of action and low cost, but have been scarcely compared with ARBs. A study comparing diuretic and ARB is therefore warranted. Methods/design: This is a randomized, double-blind, clinical trial, comparing the association of chlorthalidone and amiloride with losartan as first drug option in patients aged 30 to 70 years, with stage I hypertension. The primary outcomes will be variation of blood pressure by time, adverse events and development or worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart failure, evidence of new subclinical atherosclerosis and sudden death. The study will last 18 months. The sample size will be of 1200 participants for group in order to confer enough power to test for all primary outcomes. The project was approved by the Ethics committee of each participating institution. Discussion: The putative pleiotropic effects of ARB agents, particularly renal protection, have been disputed, and they have been scarcely compared with diuretics in large clinical trials, despite that they have been at least as efficacious as newer agents in managing hypertension. Even if the null hypothesis is not rejected, the information will be useful for health care policy to treat hypertension in Brazil.
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    Insulin Resistance Impairs Arterial Stiffness and Peripheral Vascular Resistance in Metabolic Syndrome Patients
    (2015) RODRIGUES, Sara; CEPEDA, Felipe; DUTRA-MARQUES, Akothirene; CARVALHO, Jefferson; TOSCHI-DIAS, Edgar; MAKI-NUNES, Cristiane; BORTOLOTTO, Luiz; COSTA-HONG, Valeria; RONDON, Maria; ALVES, Maria; NEGRAO, Carlos; TOMBETTA, Ivani