BRENO JOSE ALENCAR PIRES BARBOSA

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Projetos de Pesquisa
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LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 29
  • article 0 Citação(ões) na Scopus
    Diagnóstico e manejo da demência da doença de Parkinson e demência com corpos de Lewy: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia
    (2022) PARMERA, Jacy Bezerra; TUMAS, Vitor; FERRAZ, Henrique Ballalai; SPITZ, Mariana; BARBOSA, Maira Tonidandel; SMID, Jerusa; BARBOSA, Breno José Alencar Pires; SCHILLING, Lucas Porcello; BALTHAZAR, Márcio Luiz Figueiredo; SOUZA, Leonardo Cruz de; VALE, Francisco Assis Carvalho; CARAMELLI, Paulo; BERTOLUCCI, Paulo Henrique Ferreira; CHAVES, Márcia Lorena Fagundes; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; CASTILHOS, Raphael Machado; FROTA, Norberto Anízio Ferreira
    ABSTRACT Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) represent the second most common type of degenerative dementia in patients aged 65 years and older, leading to progressive cognitive dysfunction and impaired quality of life. This study aims to provide a consensus based on a systematic Brazilian literature review and a comprehensive international review concerning PDD and DLB. Moreover, we sought to report on and give recommendations about the best diagnostic approaches focusing on primary and secondary care. Based on the available data, we recommend clinicians to apply at least one brief global cognitive instrument to assess PDD, such as the Mini-Mental State Examination and preferably the Montreal Cognitive Assessment and the Addenbrooke’s Cognitive Examination-Revised. Validated instruments to accurately assess functional abilities in Brazilian PD patients are still incipient. Further studies should focus on biomarkers with Brazilian cohorts.
  • article 1 Citação(ões) na Scopus
    Reader response: Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study
    (2019) BARBOSA, Breno J. A. P.; SOUZA-TALARICO, Juliana N. de; NITRINI, Ricardo; BRUCKI, Sonia M. D.
  • conferenceObject
    Intraoperative assistive technologies and insular gliomas surgery: Results from a volumetry-based retrospective cohort
    (2016) LEPSKI, Guilherme; BARBOSA, Breno Jose Alencar Pires; DIMOSTHENI, Artemisia; TEIXEIRA, Manoel Jacobsen; TATAGIBA, Marcos
  • conferenceObject
    IMPACT OF COVID-19 PANDEMIC ON MENTAL HEALTH, SOCIAL CONNECTEDNESS AND COGNITIVE PERFORMANCE OF OLDER ADULTS
    (2021) SOUZA-TALARICO, Juliana; SILVA, Fernanda; JESUS, Maria Clara; BARBOSA, Breno J. A. P.; NITRINI, Ricardo; BRUCKI, Sonia M. D.
  • conferenceObject
    High resolution vessel wall magnetic resonance imaging in HIV associated vasculopathy
    (2017) KUBOTA, G. Taricani; FERREIRA, R. de Faria; FIGUEIREDO, T. Rocha; SANTOS, G. Titoneli dos; MORAIS, L. Martins Tavares Scianni; BARBOSA, B. J. Alencar Pires; YAMAMOTO, F. Iuji; GUEDES, B. Fukelmann; CONFORTO, A. Bastos
  • article 17 Citação(ões) na Scopus
    Adult Neurogenesis and Glial Oncogenesis: When the Process Fails
    (2014) BATISTA, Chary Marquez; MARIANO, Eric Domingos; BARBOSA, Breno Jose Alencar Pires; MORGALLA, Matthias; MARIE, Suely Kazue Nagahashi; TEIXEIRA, Manoel Jacobsen; LEPSKI, Guilherme
    Malignant brain tumors, including glioblastoma multiforme (GBM), are known for their high degree of invasiveness, aggressiveness, and lethality. These tumors are made up of heterogeneous cell populations and only a small part of these cells (known as cancer stem cells) is responsible for the initiation and recurrence of the tumor. The biology of cancer stem cells and their role in brain tumor growth and therapeutic resistance has been extensively investigated. Recent work suggests that glial tumors arise from neural stem cells that undergo a defective process of differentiation. The understanding of this process might permit the development of novel treatment strategies targeting cancer stem cells. In the present review, we address the mechanisms underlying glial tumor formation, paying special attention to cancer stem cells and the role of the microenvironment in preserving them and promoting tumor growth. Recent advancements in cancer stem cell biology, especially regarding tumor initiation and resistance to chemo-or radiotherapy, have led to the development of novel treatment strategies that focus on the niche of the stem cells that make up the tumor. Encouraging results from preclinical studies predict that these findings will be translated into the clinical field in the near future.
  • bookPart
    Nervo óptico e vias visuais
    (2021) BARBOSA, Breno José Alencar Pires
  • article 23 Citação(ões) na Scopus
    Insular gliomas and the role of intraoperative assistive technologies: Results from a volumetry-based retrospective cohort
    (2016) BARBOSA, Breno Jose Alencar Pires; DIMOSTHENI, Artemisia; TEIXEIRA, Manoel Jacobsen; TATAGIBA, Marcos; LEPSKI, Guilherme
    Introduction: In the field of Glioma surgery, there has been an increasing interest in the use of assistive technologies to overcome the difficulty of preserving brain function while improving surgical radicality. In most reports, tumor localization has seldom been considered a variable and the role of intraoperative adjuncts is yet to be determined for gliomas of the insula. Objectives: To evaluate the efficacy of fluorescence-guided resection with 5-ALA, intraoperative neurophysiological monitoring (IOM), neuronavigation, and tractography in the Extent of Resection (EOR), functionality scores, overall survival (OS) and progression-free survival (PFS) in a retrospective cohort of insular gliomas. Methods: We reviewed all cases of insular tumors operated on at the Department of Neurosurgery, University Hospital of Tubingen Germany, between May 2008 and November 2013. EOR was determined by volumetric analysis. Mann Whitney, Chi-square and Kaplan Meier functions were used for assessment of each technology's effect on primary and secondary outcomes. Results: 28 cases (18 men (64%) and 10 women (36%); median age at diagnosis: 52.5 years, range 12 - 59) were considered eligible for analysis. High grade and low grade gliomas accounted for 20 (71%) and 8 (29%) cases, respectively. The most used technologies were IOM (64%) and Neuronavigation (68%). 5-ALA was the only technique associated with EOR >= 90% (p = 0.05). Tractography determined improvement in the Karnofsky Performance Scale (50% vs. 5% cases improved, p = 0.02). There was a positive association between the use of neuronavigation and overall survival (23 vs. 27.4 months, p = 0.03), but the use of 5-ALA was associated with shorter OS (34.8 vs. 21.1 months, p = 0.01) and PFS (24.4 vs. 11.8, p = 0.01). Conclusions: We demonstrate for the first time that for insular gliomas 5-ALA plays a role in achieving higher EOR, although this technology was associated with poor OS and PFS; also tractography and neuronavigation can be of great importance in the treatment of insular gliomas as they determined better functionality and OS in this study, respectively. Prospective studies with a more prominent sample and proper multivariate analysis will help determine the real benefit of these adjuncts in the setting of insular gliomas.
  • article 1 Citação(ões) na Scopus
    Manejo das demências em fase avançada: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia
    (2022) BRUCKI, Sonia Maria Dozzi; APRAHAMIAN, Ivan; BORELLI, Wyllians Vendramini; SILVEIRA, Victor Calil da; FERRETTI, Ceres Eloah de Lucena; SMID, Jerusa; BARBOSA, Breno José Alencar Pires; SCHILLING, Lucas Porcello; BALTHAZAR, Márcio Luiz Figueiredo; FROTA, Norberto Anízio Ferreira; SOUZA, Leonardo Cruz de; VALE, Francisco Assis Carvalho; CARAMELLI, Paulo; BERTOLUCCI, Paulo Henrique Ferreira; CHAVES, Márcia Lorena Fagundes; NITRINI, Ricardo; SCHULTZ, Rodrigo Rizek; MORILLO, Lilian Schafirovits
    ABSTRACT Alzheimer’s disease (AD) and other neurodegenerative dementias have a progressive course, impairing cognition, functional capacity, and behavior. Most studies have focused on AD. Severe dementia is associated with increased age, higher morbidity-mortality, and rising costs of care. It is fundamental to recognize that severe dementia is the longest period of progression, with patients living for many years in this stage. It is the most heterogeneous phase in the process, with different abilities and life expectancies. This practice guideline focuses on severe dementia to improve management and care in this stage of dementia. As it is a long period in the continuum of dementia, clinical practice should consider non-pharmacological and pharmacological approaches. Multidisciplinary interventions (physical therapy, speech therapy, nutrition, nursing, and others) are essential, besides educational and support to caregivers.
  • article 0 Citação(ões) na Scopus
    Current clinical and research practices on frontotemporal dementia in Brazil: a national survey
    (2023) SOUZA, Leonardo Cruz de; BRUCKI, Sonia Maria Dozzi; SCHILLING, Lucas Porcello; SILVA, Leticia Costa da; TAKADA, Leonel Tadao; BAHIA, Valeria Santoro; BARBOSA, Breno Jose Alencar Pires; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; NITRINI, Ricardo; CARAMELLI, Paulo; SMID, Jerusa
    Background Frontotemporal dementia (FTD) is a frequent cause of young-onset dementia and represents a major challenge for the diagnosis and clinical management. It is essential to evaluate the difficulties faced by physicians on the diagnostic workup and on patient care.Objective The aim of this study was to investigate the current practices and the local limits on the diagnosis and management of FTD in Brazil.Methods We elaborated an online survey, composed of 29 questions and divided in four parts, comprising questions about existing health facilities, clinical practices related to FTD, and suggestions to increment the national research on FTD. The invitation to participate was sent by email to all neurologists affiliated to the Brazilian Academy of Neurology ( n = 3658), and to all physicians who attended the XII Meeting of Researchers on Alzheimer's disease, in 2019 ( n = 187). The invitation was also diffused through social media.Results 256 Brazilian physicians answered the questionnaire. The three most relevant disorders for the differential diagnosis of FTD were Alzheimer's disease (AD) ( n = 211), bipolar disorder ( n = 117) and dementia with Lewy bodies ( n = 92). Most respondents (125/256) reported the difficulty in performing genetic testing as the main limit in the diagnostic of FTD. 93% and 63% of participants considered that the assessment of social cognition and AD CSF biomarkers are useful for the diagnosis of FTD, respectively.Conclusions The present study may provide valuable insights for the medical education and clinical training of physicians, and to foster future research on FTD in Brazil.