ANDRE LUIZ PEREIRA DE ALBUQUERQUE
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
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- Computed tomography in hypersensitivity pneumonitis: main findings, differential diagnosis and pitfalls(2018) DIAS, Olivia Meira; BALDI, Bruno Guedes; PENNATI, Francesca; ALIVERTI, Andrea; CHATE, Rodrigo Caruso; SAWAMURA, Marcio Valente Yamada; CARVALHO, Carlos Roberto Ribeiro de; ALBUQUERQUE, Andre Luis Pereira deIntroduction: Hypersensitivity pneumonitis (HP) is a disease with variable clinical presentation in which inflammation in the lung parenchyma is caused by the inhalation of specific organic antigens or low molecular weight substances in genetically susceptible individuals. Alterations of the acute, subacute and chronic forms may eventually overlap, and the diagnosis based on temporality and presence of fibrosis (acute/inflammatory HP vs. chronic HP) seems to be more feasible and useful in clinical practice. Differential diagnosis of chronic HP with other interstitial fibrotic diseases is challenging due to the overlap of the clinical history, and the functional and imaging findings of these pathologies in the terminal stages.Areas covered: This article reviews the essential features of HP with emphasis on imaging features. Moreover, the main methodological limitations of high-resolution computed tomography (HRCT) interpretation are discussed, as well as new perspectives with volumetric quantitative CT analysis as a useful tool for retrieving detailed and accurate information from the lung parenchyma.Expert commentary: Mosaic attenuation is a prominent feature of this disease, but air trapping in chronic HP seems overestimated. Quantitative analysis has the potential to estimate the involvement of the pulmonary parenchyma more accurately and could correlate better with pulmonary function results.
- Weight Gain Induced by Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea Is Mediated by Fluid Accumulation: A Randomized Crossover Controlled Trial(2021) HERCULANO, Sara; GRAD, Gustavo F.; DRAGER, Luciano F.; ALBUQUERQUE, Andre L. P. de; MELO, Camila M.; LORENZI-FILHO, Geraldo; GENTA, Pedro R.
conferenceObject Diaphragmatic dysfunction in interstitial lung disease: An ultrasonography study(2014) SANTANA, Pauliane Vieira; PRINA, Elena; PLETSCH, Renata; FERREIRA, Jeferson; PEREIRA, Mayra Caleff; US, Andre Apanav; TREVISAN, Patricia; ALBUQUERQUE, Andre P.; CARVALHO, Carlos Roberto R.; CARUSO, Pedro- Respiratory muscle strength in patients post infection by COVID-19(2022) SALDANHA, M. F. Lima Souza; SOUZA, V. Costa; LIMA, M. Lafeta; MENEZES, T. Carvalho Francescantonio; PENIDO, F. Oliveira; ALBUQUERQUE, A. Luiz Pereira; TANNI, S. Erico; ARAKAKI, J. Sonoe Ota; NERY, L. Eduardo; FERREIRA, E. V. M.; SPERANDIO, P. Abreu
- Exercise performance and differences in physiological response to pulmonary rehabilitation in severe chronic obstructive pulmonary disease with hyperinflation(2016) ALBUQUERQUE, Andre Luis Pereira de; QUARANTA, Marco; CHAKRABARTI, Biswajit; ALIVERTI, Andrea; CALVERLEY, Peter M.
- Regional ventilation of patients with hemidiaphragm paralysis by electrical impedance tomography(2015) PEREIRA, Mayra Caleffi; TORSANI, Vinicius; APANAVICIUS, Andre; FERREIRA, Jeferson George; IAMONTI, Vinicius C.; AMATO, Marcelo Britto Passos; CARVALHO, Carlos Roberto Ribeiro de; ALBUQUERQUE, Andre Luis Pereira de; CARUSO, Pedro
- Texture-based classification of lung disease patterns in chronic hypersensitivity pneumonitis and comparison to clinical outcomes(2021) PENNATI, F.; ALIBONI, L.; ANTONIAZZA, A.; BERETTA, D.; DIAS, O.; BALDI, B. G.; SAWAMURA, M.; CHATE, R. C.; CARVALHO, C. R. R. De; ALBUQUERQUE, A.; ALIVERTI, A.Computer-aided detection algorithms applied to CT lung imaging have the potential to objectively quantify pulmonary pathology. We aim to develop an automatic classification method based on textural features able to classify healthy and pathological patterns on CT lung images and to quantify the extent of each disease pattern in a group of patients with chronic hypersensitivity pneumonitis (cHP), in comparison to pulmonary function tests (PFTs). 27 cHP patients were scanned via high resolution CT (HRCT) at full-inspiration. Regions of interest (ROIs) were extracted and labeled as normal (NOR), ground glass opacity (GGO), reticulation (RET), consolidation (C), honeycombing (HB) and air trapping (AT). For each ROI, statistical, morphological and fractal parameters were computed. For automatic classification, we compared two classification methods (Bayesian and Support Vector Machine) and three ROI sizes. The classifier was therefore applied to the overall CT images and the extent of each class was calculated and compared to PFTs. Better classification accuracy was found for the Bayesian classifier and the 16x16 ROI size: 92.1 +/- 2.7%. The extent of GGO, HB and NOR significantly correlated with forced vital capacity (FVC) and the extent of NOR with carbon monoxide diffusing capacity (DLCO).
conferenceObject Comparison of thoracoabdominal asynchrony estimated via optolectronic and inductive respiratory plethymographies(2014) PEREIRA, Mayra Caleffi; PORRAS, Desiderio Cano; CLAUDINO, Renata Cleia; CARDENAS, Leticia; PLETSCH, Renata; SANTANA, Pauliane; IAMONTI, Vinicius; MALONIR, Renan; CARVALHO, Carlos R. R.; CARVALHO, Celso; ALBUQUERUQE, Andre L. P.- Comparison of thoracoabdominal synchrony using two methods in healthy subjects, chronic obstructive and interstitial lung disease(2016) PEREIRA, Mayra Caleffi; FERREIRA, Jeferson; IAMONTI, Vinicius; TREVISAN, Patricia; APANAVICIUS, Andre; SANTANA, Pauliane; CARDENAS, Leticia; CARVALHO, Carlos Roberto Ribeiro de; CARUSO, Pedro; ALBUQUERQUE, Andre Luis Pereira de
- Mechanisms of Exercise Limitation and Prevalence of Pulmonary Hypertension in Pulmonary Langerhans Cell Histiocytosis(2020) HEIDEN, Glaucia Itamaro; SOBRAL, Juliana Barbosa; FREITAS, Carolina Salim Goncalves; ALBUQUERQUE, Andre Luis Pereira de; SALGE, Joao Marcos; KAIRALLA, Ronaldo Adib; FERNANDES, Caio Julio Cesar dos Santos; CARVALHO, Carlos Roberto Ribeiro; SOUZA, Rogerio; BALDI, Bruno GuedesBACKGROUND: Pulmonary Langerhans cell histiocytosis (PLCH) determines reduced exercise capacity. The speculated mechanisms of exercise impairment in PLCH are ventilatory and cardiocirculatory limitations, including pulmonary hypertension (PH). RESEARCH QUESTION: What are the mechanisms of exercise limitation, the exercise capacity , and the prevalence of dynamic hyperinflation (DH) and PH in PLCH? STUDY DESIGN AND METHODS: In a cross-sectional study, patients with PLCH underwent an incremental treadmill cardiopulmonary exercise test with an evaluation of DH, pulmonary function tests, and transthoracic echocardiography. Those patients with lung diffusing capacity for carbon monoxide (D-LCO) < 40% predicted and/or transthoracic echocardiogram with tricuspid regurgitation velocity > 2.5 m/s and/or with indirect PH signs underwent right heart catheterization. RESULTS: Thirty-five patients were included (68% women; mean age, 47 +/- 11 years). Ventilatory and cardiocirculatory limitations, impairment suggestive of PH, and impaired gas exchange occurred in 88%, 67%, 29%, and 88% of patients, respectively. The limitation was multifactorial in 71%, exercise capacity was reduced in 71%, and DH occurred in 68% of patients. FEV1 and D-LCO were 64 +/- 22% predicted and 56 +/- 21% predicted. Reduction in D-LCO, an obstructive pattern, and air trapping occurred in 80%, 77%, and 37% of patients. FEV1 and D-LCO were good predictors of exercise capacity. The prevalence of PH was 41%, predominantly with a precapillary pattern, and mean pulmonary artery pressure correlated best with FEV1 and tricuspid regurgitation velocity. INTERPRETATION: PH is frequent and exercise impairment is common and multifactorial in PLCH. The most prevalent mechanisms are ventilatory, cardiocirculatory, and suggestive of PH limitations.