DANIEL RUBIO DE SOUZA
Índice h a partir de 2011
6
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina
IRLM, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
IRLM, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- Electroencephalography as a Biomarker for Functional Recovery in Spinal Cord Injury Patients(2021) SIMIS, Marcel; CAMSARI, Deniz Doruk; IMAMURA, Marta; FILIPPO, Thais Raquel Martins; SOUZA, Daniel Rubio De; BATTISTELLA, Linamara Rizzo; FREGNI, FelipeBackground Functional changes after spinal cord injury (SCI) are related to changes in cortical plasticity. These changes can be measured with electroencephalography (EEG) and has potential to be used as a clinical biomarker. Method In this longitudinal study participants underwent a total of 30 sessions of robotic-assisted gait training (RAGT) over a course of 6 weeks. The duration of each session was 30 min. Resting state EEG was recorded before and after 30-session rehabilitation therapy. To measure gait, we used the Walking Index for Spinal Cord Injury Scale, 10-Meter- Walking Test, Timed-Up-and-Go, and 6-Min-Walking Test. Balance was measured using Berg Balance Scale. Results Fifteen participants with incomplete SCI who had AIS C or D injuries based on American Spinal Cord Injury Association Impairment Scale classification were included in this study. Mean age was 35.7 years (range 17-51) and the mean time since injury was 17.08 (range 4-37) months. All participants showed clinical improvement with the rehabilitation program. EEG data revealed that high beta EEG activity in the central area had a negative correlation with gait (p = 0.049; beta coefficient: -0.351; and adj-R-2: 0.23) and balance (p = 0.043; beta coefficient: -0.158; and adj-R-2:0.24) measured at baseline, in a way that greater high beta EEG power was related to worse clinical function at baseline. Moreover, improvement in gait and balance had negative correlations with the change in alpha/theta ratio in the parietal area (Gait: p = 0.049; beta coefficient: -0.351; adj-R-2: 0.23; Balance: p = 0.043; beta coefficient: -0.158; and adj-R-2: 0.24). Conclusion In SCI, functional impairment and subsequent improvement following rehabilitation therapy with RAGT correlated with the change in cortical activity measured by EEG. Our results suggest that EEG alpha/theta ratio may be a potential surrogate marker of functional improvement during rehabilitation. Future studies are necessary to improve and validate these findings as a neurophysiological biomarker for SCI rehabilitation.
- Relationship between the coronavirus disease 2019 pandemic and immobilization syndrome(2021) PLAPLER, Perola Grinberg; SOUZA, Daniel Rubio de; KAZIYAMA, Helena Hideko Seguchi; BATTISTELLA, Linamara Rizzo; BARROS-FILHO, Tarcisio Eloy Pessoa de