CLARICE GORENSTEIN
Projetos de Pesquisa
Unidades Organizacionais
BMF, ICB - Docente
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
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- The Beck depression inventory: Uses and applications(2021) WANG, Y. P.; GORENSTEIN, C.The Beck depression inventory (BDI) is among the most used self-rating scales for measuring depression worldwide. Since the test construction in 1961, the BDI has been employed in more than 14,000 empirical studies. This chapter discusses the utility of the BDI based on previous studies on its psychometric properties. We only consider those studies that are primarily concerned with the validity of the psychometric properties. The advantages of the BDI are its good internal consistency, sensitivity to change, broad construct validity, flexible criterion validity in differentiating between depressed and nondepressed subjects, and international propagation. The main limitations of the tool are the lack of representative norms, doubtful objectivity of interpretation, and controversial factorial validity. Agreements and contradictions between the various studies, as well as potential factors (sampling issues, statistical procedures, sensitivity to change) accounting for the variance in their results, are discussed. © 2021 Elsevier Inc. All rights reserved.
- Assessment scoring tools of depression(2021) GORENSTEIN, C.; HENNA, E.; WANG, Y. P.Depression is a common psychiatric disorder and is associated with severe impairment in the patient’s lives. Even so, depressive conditions remain underdiagnosed and its assessment is made mainly by clinical judgment, which brings an unavoidable decrease in diagnostic reliability. There are several instruments widely used in research, which aim to enhance the detection of depression, to ensure diagnosis accuracy, to register the intensity of symptoms, and to follow-up the treatment efficacy. This chapter aims to present the most used scales for screening, diagnosing, and measuring outcomes in depression. Further, we highlight the psychometric properties of assessment tools of depression, to help clinicians to select the best-suited ones for their purposes. © 2021 Elsevier Inc. All rights reserved.
- The neuroscience of depression: Mechanisms and treatments(2021) WANG, Y. P.; GORENSTEIN, C.; Sá JUNIOR, A. R. deThe present chapter summarizes aspects of depression among college students, who experience higher rates of depression than those found in general population. Depression in students is often associated with some risk behaviors, such as suicidal thoughts and attempts, non-suicidal self-injury, and substance abuse. Although universal screening of depression is recommended among students, resources of mental health should be available before implementing a screening program. Early identification and management may improve symptoms of depression, increase academic performance, and prevent college dropout. Counseling, psychotherapy, and psychopharmacotherapy are treatment options for depression in college campus. Many students with depression prefer managing their problems by themselves, delaying the help-seeking and aggravating the severity of depression. The effectiveness of interventions is associated with student’s suboptimal adherence and response rate to treatment. Therefore, access to health care should be improved, in terms of the adequacy and quality of the service offered to students with depression. © 2021 Elsevier Inc. All rights reserved.
conferenceObject CLINICAL UTILITY OF THE MONTGOMERY-ASBERG DEPRESSION RATING SCALE FOR THE DETECTION OF DEPRESSION AMONG BARIATRIC SURGERY CANDIDATES(2016) DUARTE-GUERRA, L. S.; GORENSTEIN, C.; PAIVA-MEDEIROS, P. F.; SANTO, M. A.; LOTUFO-NETO, F.; WANG, Y. P.- Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions(2014) CERQUEIRA, C. T.; SATO, J. R.; ALMEIDA, J. R. C. de; AMARO JR., E.; LEITE, C. C.; GORENSTEIN, C.; GENTIL, V.; BUSATTO, G. F.Various functional magnetic resonance imaging studies addressed the effects of antidepressant drugs on brain functioning in healthy subjects; however, none specifically investigated positive mood changes to antidepressant drug. Sixteen subjects with no personal or family history of psychiatric disorders were selected from an ongoing 4-week open trial of small doses of clomipramine. Follow-up interviews documented clear positive treatment effects in six subjects, with reduced irritability and tension in social interactions, improved decision making, higher self-confidence and brighter mood. These subjects were then included in a placebo-controlled confirmatory trial and were scanned immediately after 4 weeks of clomipramine use and again 4 weeks after the last dose of clomipramine. The functional magnetic resonance imaging (fMRI) scans were run during emotion-eliciting stimuli. Repeated-measures analysis of variance of brain activity patterns showed significant interactions between group and treatment status during induced irritability (P < 0.005 cluster-based) but not during happiness. Individuals displaying a positive subjective response do clomipramine had higher frontoparietal cortex activity during irritability than during happiness and neutral emotion, and higher temporo-parieto-occipital cortex activity during irritability than during happiness. We conclude that antidepressants not only induce positive mood responses but also act upon autobiographical recall of negative emotions.