FELIPE BARJUD PEREIRA DO NASCIMENTO
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3
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina - Médico
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bookPart Doenças da região selar e dos tecidos adjacentes(2017) NASCIMENTO, Felipe Barjud Pereira do; KODAIRA, Sergio Keidi; SILVA, Fábio Eduardo Fernandes da- Detection of the source of hemorrhage using postmortem computerized tomographic angiography in a case of a giant juvenile nasopharyngeal angiofibroma after surgical treatment(2015) NASCIMENTO, Felipe Barjud Pereira do; SANTOS, Glaucia Aparecida Bento dos; MELO, Nelson Almeida d'Avila; DAMASCENO, Eduarda Bittencourt; MAUAD, ThaisPurpose Postmortem computerized tomographic angiography (PMCTA) has been increasingly used in forensic medicine to detect and locate the source of bleeding in cases of fatal acute hemorrhage. In this paper, we report a case of postoperative complication in a patient with a giant juvenile nasopharyngeal angiofibroma in which the source of bleeding was detected by PMCTA. Methods A case description and evaluations of the pre- and postoperative exams, postmortem CT angiogram, and conventional autopsy results are provided. Results The source of bleeding was identified by postmortem CT angiography but not by conventional autopsy. The established protocol, injecting contrast medium into the femoral artery, was effective in identifying the source of bleeding. Conclusions Postoperative bleeding is a rare and frequently fatal complication of juvenile nasopharyngeal angiofibroma. As a complement to conventional autopsy, postmortem angiography is a valuable tool for the detection of lethal acute hemorrhagic foci, and establishing a routine procedure for PMCTA may improve its efficiency.
- Substantia nigra fractional anisotropy is not a diagnostic biomarker of Parkinson's disease: A diagnostic performance study and meta-analysis(2017) HIRATA, Fabiana C. C.; SATO, Joao R.; VIEIRA, Gilson; LUCATO, Leandro T.; LEITE, Claudia C.; BOR-SENG-SHU, Edson; PASTORELLO, Bruno F.; OTADUY, Maria C. G.; CHAIM, Khallil T.; CAMPANHOLO, Kenia R.; NOVAES, Natalia P.; MELO, Luciano Magalhaes; GONCALVES, Marcia R.; NASCIMENTO, Felipe Barjud Pereira do; TEIXEIRA, Manoel Jacobsen; BARBOSA, Egberto Reis; AMARO JR., Edson; CARDOSO, Ellison FernandoObjectives Our goal was to estimate the diagnostic accuracy of substantia nigra fractional anisotropy (SN-FA) for Parkinson's disease (PD) diagnosis in a sample similar to the clinical setting, including patients with essential tremor (ET) and healthy controls (HC). We also performed a systematic review and meta-analysis to estimate mean change in SN-FA induced by PD and its diagnostic accuracy. Methods Our sample consisted of 135 subjects: 72 PD, 21 ET and 42 HC. To address inter-scanner variability, two 3.0-T MRI scans were performed. MRI results of this sample were pooled into a meta-analysis that included 1,432 subjects (806 PD and 626 HC). A bivariate model was used to evaluate diagnostic accuracy measures. Results In our sample, we did not observe a significant effect of disease on SN-FA and it was uninformative for diagnosis. The results of the meta-analysis estimated a 0.03 decrease in mean SN-FA in PD relative to HC (CI: 0.01-0.05). However, the discriminatory capability of SN-FA to diagnose PD was low: pooled sensitivity and specificity were 72 % (CI: 68-75) and 63 % (CI: 58-70), respectively. There was high heterogeneity between studies (I-2 = 91.9%). Conclusions SN-FAcannot be used as an isolatedmeasure to diagnose PD.