FELIPE BARJUD PEREIRA DO NASCIMENTO

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Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • bookPart
    Doenças da região selar e dos tecidos adjacentes
    (2017) NASCIMENTO, Felipe Barjud Pereira do; KODAIRA, Sergio Keidi; SILVA, Fábio Eduardo Fernandes da
  • article 24 Citação(ões) na Scopus
    Substantia nigra fractional anisotropy is not a diagnostic biomarker of Parkinson's disease: A diagnostic performance study and meta-analysis
    (2017) HIRATA, Fabiana C. C.; SATO, Joao R.; VIEIRA, Gilson; LUCATO, Leandro T.; LEITE, Claudia C.; BOR-SENG-SHU, Edson; PASTORELLO, Bruno F.; OTADUY, Maria C. G.; CHAIM, Khallil T.; CAMPANHOLO, Kenia R.; NOVAES, Natalia P.; MELO, Luciano Magalhaes; GONCALVES, Marcia R.; NASCIMENTO, Felipe Barjud Pereira do; TEIXEIRA, Manoel Jacobsen; BARBOSA, Egberto Reis; AMARO JR., Edson; CARDOSO, Ellison Fernando
    Objectives Our goal was to estimate the diagnostic accuracy of substantia nigra fractional anisotropy (SN-FA) for Parkinson's disease (PD) diagnosis in a sample similar to the clinical setting, including patients with essential tremor (ET) and healthy controls (HC). We also performed a systematic review and meta-analysis to estimate mean change in SN-FA induced by PD and its diagnostic accuracy. Methods Our sample consisted of 135 subjects: 72 PD, 21 ET and 42 HC. To address inter-scanner variability, two 3.0-T MRI scans were performed. MRI results of this sample were pooled into a meta-analysis that included 1,432 subjects (806 PD and 626 HC). A bivariate model was used to evaluate diagnostic accuracy measures. Results In our sample, we did not observe a significant effect of disease on SN-FA and it was uninformative for diagnosis. The results of the meta-analysis estimated a 0.03 decrease in mean SN-FA in PD relative to HC (CI: 0.01-0.05). However, the discriminatory capability of SN-FA to diagnose PD was low: pooled sensitivity and specificity were 72 % (CI: 68-75) and 63 % (CI: 58-70), respectively. There was high heterogeneity between studies (I-2 = 91.9%). Conclusions SN-FAcannot be used as an isolatedmeasure to diagnose PD.