CAROLINA FERNANDES GUALQUI
Índice h a partir de 2011
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LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
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- Neuropsychological profile of patients with infectious disease: characterization and comparison of patients with HIV, HTLV, and HCV(2023) GASCON, Maria Rita Polo; OLIVEIRA, Giovana S. de; LAURENCE, Paulo Guirro; GUALQUI, Carolina Fernandes; OLIVEIRA, Augusto Cesar Penalva de; SMID, Jerusa; FONSECA, Luiz A. M.; CASSEB, Jorge; MACEDO, Elizeu CoutinhoUnderstanding the effect of the HIV, HTLV-1, and HCV viruses on cognitive aspects can help in the better characterization of dementia, as well as the best conducts to be suitable for rehabilitation. Thus, the present study aimed to characterize and compare the neuropsychological profile of 3 groups of patients with infectious diseases: HIV, HTLV, and HCV. The results of neuropsychological assessments and depression assessment of 325 people treated at a referral hospital for infectious dis-eases were analyzed, being 120 HIV carriers (74 (61.7%) men) with an average age of 47.5 years (SD = 10.3), 65 patients with HTLV-1 (16 (24.6%) men) with a mean age of 49.9 years (SD = 12.9), and 87 HCV patients (47 (54%) men) with a mean age of 55.5 years (SD = 11.2). In addition, 54 people (26 (48.1%) men) with negative serology who made up the con-trol group were evaluated. The results of the statistical evaluation of the sociodemographic factors of the four groups (HIV, HTLV-1, HCV, and control) showed that in addition to age, schooling was a significant factor among them and may have a strong influence on the performance of cognitive tests. The HTLV-1 group had the lowest neurocognitive performance and also the highest rate of depressive symptoms.
- Prevalence of cognitive impairment in HIV patients: vertical and horizontal transmission(2022) GASCÓN, Maria Rita Polo; TERRA, Cauê Peter da Cruz; GUERRA, Hestela de Lima; GUALQUI, Carolina Fernandes; LUCIA, Mara Cristina Souza De; BENUTE, Glaucia Rosana Guerra; FONSECA, Luiz Augusto Marcondes; CASSEB, Jorge; VIDAL, Jose Ernesto; OLIVEIRA, Augusto César Penalva deABSTRACT. Antiretroviral treatment has significantly increased the survival of patients infected with HIV-1. However, with increased survival, cognitive changes associated with HIV are frequently observed in this population. The clinical manifestations of HIV changes can vary as a result of several aspects, including the virus transmission route. Several studies have pointed out premature neurological changes in vertically infected patients, while the manifestation of cognitive damage in adults may take a longer time. Objective: The aim of this study was to verify the prevalence of cognitive changes in patients with HIV via vertical transmission after the highly active antiretroviral therapy and the cognitive performance of these patients compared to a group of sexually infected patients. Methods: A total of 48 patients were evaluated, 25 with vertical transmission and 23 with sexual transmission, between May 2013 and February 2015 at the Institute of infectology Emilio Ribas. Neuropsychological tests were applied to assess cognitive performance, scales to assess symptoms of anxiety and depression, and sociodemographic questionnaire. Results: The results demonstrate that the frequency of cognitive impairment in vertically transmitted patients was higher than in sexually transmitted patients. Conclusions: These findings suggest that the deleterious effects of the HIV virus on the development of the central nervous system reverberate more strongly than in patients who acquire it after adulthood.