LETICIA LESSA MANSUR
Projetos de Pesquisa
Unidades Organizacionais
LIM/34 - Laboratório de Ciências da Reabilitação, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
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- Inference comprehension from reading in individuals with mild cognitive impairment(2021) SILAGI, Marcela Lima; ROMERO, Vivian Urbanejo; OLIVEIRA, Maira Okada de; TRES, Eduardo Sturzeneker; BRUCKI, Sonia Maria Dozzi; RADANOVIC, Marcia; MANSUR, Leticia LessaInference comprehension is a complex ability that recruits distinct cognitive domains, such as language, memory, attention, and executive functions. Therefore, it might be sensitive to identify early deficits in subjects with MCI. To compare the performance of subjects with mild cognitive impairment (MCI) in an inference reading comprehension task, and to analyze the correlations between inferential comprehension and other cognitive functions. We studied 100 individuals aged 60 and over, divided into MCI (50) [aMCI (35), naMCI (15)], and cognitively healthy individuals [controls (50)]. The Implicit Management Test (IMT) was used to assess inference in reading comprehension in five categories: explicit, logical, distractor, pragmatic, and ""others"". MCI group performed worse than controls in logical, pragmatic, distractor, and ""others"" questions (p < 0.01). The aMCI and naMCI subgroups presented a similar performance in all types of questions (p > 0.05). We observed significant correlations between the total IMT score and the TMT-A in the naMCI group (r = - 0.562, p = 0.036), and the Rey-Osterrieth Complex Figure and RAVLT tasks in the aMCI group (r = 0.474, p = 0.010 and r = 0.593, p = 0.0001, respectively). The MCI group as a whole performed worse than controls on the logical, pragmatic, other and distractor questions, and consequently on the total score. There were no differences in explicit questions, which impose lower inferential demands. The aMCI group suffered a significant impact from memory on inference comprehension, and difficulties in executive functions impacted naMCI performance. The IMT was useful to differentiate MCI patients from cognitively healthy individuals, but not MCI subgroups among themselves.
- Engagement of Language and Domain General Networks during Word Monitoring in a Native and Unknown Language(2021) COTOSCK, Kelly R.; MELTZER, Jed A.; NUCCI, Mariana P.; LUKASOVA, Katerina; MANSUR, Leticia L.; JR, Edson AmaroFunctional neuroimaging studies have highlighted the roles of three networks in processing language, all of which are typically left-lateralized: a ventral stream involved in semantics, a dorsal stream involved in phonology and speech production, and a more dorsal ""multiple demand"" network involved in many effortful tasks. As lateralization in all networks may be affected by life factors such as age, literacy, education, and brain pathology, we sought to develop a task paradigm with which to investigate the engagement of these networks, including manipulations to selectively emphasize semantic and phonological processing within a single task performable by almost anyone regardless of literacy status. In young healthy participants, we administered an auditory word monitoring task, in which participants had to note the occurrence of a target word within a continuous story presented in either their native language, Portuguese, or the unknown language, Japanese. Native language task performance activated ventral stream language networks, left lateralized but bilateral in the anterior temporal lobe. Unfamiliar language performance, being more difficult, activated left hemisphere dorsal stream structures and the multiple demand network bilaterally, but predominantly in the right hemisphere. These findings suggest that increased demands on phonological processing to accomplish word monitoring in the absence of semantic support may result in the bilateral recruitment of networks involved in speech perception under more challenging conditions.
- Dementia in Latin America: Paving the way toward a regional action plan(2021) PARRA, Mario Alfredo; BAEZ, Sandra; SEDENO, Lucas; CAMPO, Cecilia Gonzalez; SANTAMARIA-GARCIA, Hernando; APRAHAMIAN, Ivan; BERTOLUCCI, Paulo H. F.; BUSTIN, Julian; BICALHO, Maria Aparecida Camargos; CANO-GUTIERREZ, Carlos; CARAMELLI, Paulo; CHAVES, Marcia L. F.; COGRAM, Patricia; BEBER, Barbara Costa; COURT, Felipe A.; SOUZA, Leonardo Cruz de; CUSTODIO, Nilton; DAMIAN, Andres; CRUZ, Myriam de la; RODRIGUEZ, Roberta Diehl; BRUCKI, Sonia Maria Dozzi; FAJERSZTAJN, Lais; FARIAS, Gonzalo A.; FELICE, Fernanda G. De; FERRARI, Raffaele; OLIVEIRA, Fabricio Ferreira de; FERREIRA, Sergio T.; FERRETTI, Ceres; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; FUENTES, Patricio; GARCIA, Adolfo M.; GARCIA, Patricia J.; PORTO, Fabio Henrique de Gobbi; PENAILILLO, Lissette Duque; ENGLER, Henry Willy; MAIER, Irene; MATA, Ignacio F.; GONZALEZ-BILLAULT, Christian; LOPEZ, Oscar L.; MORELLI, Laura; NITRINI, Ricardo; QUIROZ, Yakeel T.; BARRAGAN, Alejandra Guerrero; HUEPE, David; PIO, Fabricio Joao; SUEMOTO, Claudia Kimie; KOCHHANN, Renata; KOCHEN, Silvia; KUMFOR, Fiona; LANATA, Serggio; MILLER, Bruce; MANSUR, Leticia Lessa; HOSOGI, Mirna Lie; LILLO, Patricia; GUERRA, Jorge Llibre; LIRA, David; LOPERA, Francisco; COMAS, Adelina; AVILA-FUNES, Jose Alberto; SOSA, Ana Luisa; RAMOS, Claudia; RESENDE, Elisa de Paula Franca; SNYDER, Heather M.; TARNANAS, Ioannis; YOKOYAMA, Jenifer; LLIBRE, Juan; CARDONA, Juan Felipe; POSSIN, Kate; KOSIK, Kenneth S.; MONTESINOS, Rosa; MOGUILNER, Sebastian; SOLIS, Patricia Cristina Lourdes; FERRETTI-REBUSTINI, Renata Eloah de Lucena; RAMIREZ, Jeronimo Martin; MATALLANA, Diana; MBAKILE-MAHLANZA, Lingani; TON, Alyne Mendonca Marques; TAVARES, Ronnielly Melo; MIOTTO, Eliane C.; MUNIZ-TERRERA, Graciela; MUNOZ-NEVAREZ, Luis Arnoldo; OROZCO, David; OLIVEIRA, Maira Okada de; PIGUET, Olivier; CAIPA, Maritza Pintado; ESCUDERO, Stefanie Danielle Pina; SCHILLING, Lucas Porcello; PALMEIRA, Andre Luiz Rodrigues; YASSUDA, Monica Sanches; SANTACRUZ-ESCUDERO, Jose Manuel; SERAFIM, Rodrigo Bernardo; SMID, Jerusa; SLACHEVSKY, Andrea; SERRANO, Cecilia; SOTO-ANARI, Marcio; TAKADA, Leonel Tadao; GRINBERG, Lea Tenenholz; TEIXEIRA, Antonio Lucio; BARBOSA, Maira Tonidandel; TREPEL, Dominic; IBANEZ, AgustinAcross Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
- Oral dyspraxia in self-limited epilepsy with centrotemporal spikes: a comparative study with a control group(2021) BERNARDO, Henrique Nicola Santo Antonio; MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes de; MANSUR, Leticia LessaBackground: self-limited epilepsy with centrotemporal spikes, previously considered benign focal childhood epilepsy with centrotemporal spikes show clinical signs of involvement of Rolandic areas, mainly lower area, which may affect the planning and execution of motor sequences. Objective:This study aimed to evaluated oral praxis in children with self-limited epilepsy with centrotemporal spikes and compare to the age-matched control group. Methods: This was a descriptive study with 74 children with self-limited epilepsy with centrotemporal spikes, with the classical forms according to International League Against Epilepsy, and between 4 and 15 years of age, selected from the child neurology outpatient clinic of the Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, and 239 age-matched and educational level-matched (convenience sampling) control children. All children were submitted to the battery of oral volitional movements, which consisted of 44 tests for oral movement (tongue, lip, cheek, jaw, and palate) and 34 phonemes and consonant cluster tasks, with simple and sequenced oral movements. Results: The mean age and standard deviation (SD) of children with epilepsy was 9.08 years (SD 2.55) and of controls 9.61 years (SD 3.12). The results showed significant differences between the groups with a poorer performance of children with epilepsy compared to children without epilepsy in simple and particularly in sequenced movements. Conclusion: These findings can be attributed to the genetically determined immaturity of cortical structures related to motor planning in children with self-limited epilepsy with centrotemporal spikes.