MICHELLE PATROCINIO ROCHA
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- Changing pattern of gonadotropins in a patient with an adrenal-androgen secreting tumor(2011) MARCONDES, Jose Antonio Miguel; BARCELLOS, Cristiano R. G.; ROCHA, Michelle P.; BISI, Helio
bookPart Síndrome dos ovários policísticos e obesidade(2015) BARCELLOS, Cristiano Roberto Grimaldi; MARCONDES, José Antonio Miguel; ROCHA, Michelle Patrocínio; DANTAS, Wagner Silvaarticle 17 Citação(ões) na Scopus Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors(2015) BARCELLOS, Cristiano Roberto Grimaldi; ROCHA, Michelle Patrocinio; HAYASHIDA, Sylvia Asaka Yamashita; DANTAS, Wagner Silva; YANCE, Viviane dos Reis Vieira; MARCONDES, Jose Antonio MiguelOBJECTIVE: The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation-tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (CV) risk factors (diabetes, dyslipidemia and arterial hypertension). DESIGN: Twenty-five young women with PCOS and 23 eumenorrheic women without major CV risk factors and matched for body mass index (BMI) were studied. They were subdivided according to BMI and PCOS status and comparisons were made between the PCOS and Control groups, regardless of BMI, and between the Obese and Lean groups, regardless of the presence of PCOS. RESULTS: Levels of TNF-alpha, IL-6 and hsCRP were similar between the PCOS group and the Control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-alpha were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hsCRP were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively). CONCLUSION: Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without majorCV risk factors.- Dyslipidemia in women with polycystic ovary syndrome: incidence, pattern and predictors(2011) ROCHA, Michelle P.; MARCONDES, Jose A. M.; BARCELLOS, Cristiano R. G.; HAYASHIDA, Sylvia A. Y.; CURI, Daniela D. G.; FONSECA, Angela M. da; BAGNOLI, Vicente R.; BARACAT, Edmund C.One hundred forty-two women with polycystic ovary syndrome (PCOS) with an average body mass index (BMI) of 29.1 kg/m(2) and average age of 25.12 years were studied. By BMI, 30.2% were normal, 38.0% were overweight and 31.6% were obese. Thirty-one eumenorrheic women matched for BMI and age, with no evidence of hyperandrogenism, were recruited as controls. The incidence of dyslipidemia in the PCOS group was twice that of the Control group (76.1% versus 32.25%). The most frequent abnormalities were low high-density lipoprotein cholesterol (HDL-C; 57.6%) and high triglyceride (TG) (28.3%). HDL-C was significantly lower in all subgroups of women with PCOS when compared to the subgroups of normal women. No significant differences were seen in the total cholesterol (p = 0.307), low-density lipoprotein cholesterol (LDL-C; p = 0.283) and TGs (p = 0.113) levels among the subgroups. An independent effect on HDL-C was detected for glucose (p = 0.004) and fasting insulin (p = 0.01); on TG for age (p = 0.003) and homeostatic model assessment insulin resistance (p = 0.03) and on total cholesterol and LDL-C for age (p = 0.02 and p = 0.033, respectively). In conclusion, dyslipidemia is common in women with PCOS, mainly due to low HDL-C levels. BMI has a significant impact on this abnormality.
- Evaluation of macroprolactinemia in 259 women under investigation for polycystic ovary syndrome(2014) HAYASHIDA, Sylvia A. Y.; MARCONDES, Jose A. M.; SOARES JR., Jose M.; ROCHA, Michelle P.; BARCELLOS, Cristiano R. G.; KOBAYASHI, Nelly K. A.; BARACAT, Edmund C.; MACIEL, Gustavo A. R.