MARCELO HOUAT DE BRITO
Índice h a partir de 2011
4
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
- Reverse crossed cerebellar diaschisis in status epilepticus: case report(2020) BRITO, Marcelo Houat De; GRATIVVOL, Ronnyson Susano; LUCATO, Leandro Tavares; PINTO, Lecio Figueira
- Central Nervous System Demyelination Associated With Immune Checkpoint Inhibitors: Review of the Literature(2020) OLIVEIRA, Marcos C. B.; BRITO, Marcelo H. de; SIMABUKURO, Mateus M.Immune checkpoint inhibitors (ICI) are a novel class of antineoplastic treatment that enhances immunity against tumors. They are associated with immune adverse events, and several neurological syndromes have been described, including multiple sclerosis and atypical demyelination. We performed a systematic literature review of case reports with neurological immune adverse events that presented with central nervous system demyelination, up to December 2019. We found 23 cases: seven with myelitis, four isolated optic neuritis, one neuromyelitis optica spectrum disorder, five multiple sclerosis, and six with atypical demyelination. Ipilimumab was the most frequently used ICI (11/23). The median time to develop symptoms from the onset of ICI was 6.5 weeks [range 1.0-43.0], and from last ICI dose was 14 days [range 0-161]. Anatomopathological examination was performed in four cases, with the finding of a T-cell mediated immune response. Outcomes were generally favorable after immunosuppression: 18 patients had improvement or a full recovery, three patients did not respond to treatment, three patients died, and in one, treatment was not reported. We describe the patients' clinical presentation, treatment administered, and outcomes. We further speculate on possible pathophysiological mechanisms and discuss potential treatments that may be worth investigating.
- Gerstmann's syndrome and unilateral optic ataxia in the emergency department(2017) BARBOSA, Breno José Alencar Pires; BRITO, Marcelo Houat de; RODRIGUES, Júlia Chartouni; KUBOTA, Gabriel Taricani; PARMERA, Jacy BezerraABSTRACT. A 75-year-old right-handed woman presented to the emergency department with simultanagnosia and right unilateral optic ataxia. Moreover, the patient had agraphia, acalculia, digital agnosia and right-left disorientation, consistent with complete Gerstmann's syndrome. This case highlights the concurrence of Gerstmann's syndrome and unilateral optic ataxia in the acute phase of a left middle cerebral artery stroke.
- Brain [18F]FDG PET-CT imaging in posterior cortical atrophy(2019) BRITO, Marcelo Houat De; ZAMPIERI, Poliana Fonseca; COUTINHO, Artur Martins; BRUCKI, Sonia Maria Dozzi
- CLIPPERS With Exclusive Extra Pontine Involvement(2021) PICARELLI, Helder; YAMAKI, Vitor Nagai; CASAL, Yuri Reis; BRITO, Marcelo Houat de; LIMA, Luiz Guilherme Cernaglia Aureliano de; AYRES, Aline Sgnolf; OLIVEIRA, Marcos Castello Barbosa de
- Second-Generation RT-QuIC Assay for the Diagnosis of Creutzfeldt-Jakob Disease Patients in Brazil(2020) BARBOSA, Breno Jose Alencar Pires; CASTRILLO, Bruno Batitucci; ALVIM, Ricardo Pires; BRITO, Marcelo Houat de; GOMES, Helio R.; BRUCKI, Sonia M. D.; SMID, Jerusa; NITRINI, Ricardo; LANDEMBERGER, Michele C.; MARTINS, Vilma R.; SILVA, Jerson L.; VIEIRA, Tuane C. R. G.The recent development of IQ-CSF, the second generation of real-time quaking-induced conversion (RT-QuIC) using cerebrospinal fluid (CSF), for the diagnosis of Creutzfeldt-Jakob Disease (CJD) represents a major diagnostic advance in the field. Highly accurate results have been reported with encouraging reproducibility among different centers. However, availability is still insufficient, and only a few research centers have access to the method in developing countries. In Brazil, we have had 603 suspected cases of CJD since 2005, when surveillance started. Of these, 404 were undiagnosed. This lack of diagnosis is due, among other factors, to the lack of a reference center for the diagnosis of these diseases in Brazil, resulting in some of these samples being sent abroad for analysis. The aim of this research study is to report the pilot use of IQ-CSF in a small cohort of Brazilian patients with possible or probable CJD, implementing a reference center in the country. We stored CSF samples from patients with possible, probable or genetic CJD (one case) during the time frame of December 2016 through June 2018. All CSF samples were processed according to standardized protocols without access to the clinical data. Eight patients presented to our team with rapidly progressive dementia and typical neurological signs of CJD. We used CSF samples from seven patients with other neurological conditions as negative controls. Five out of seven suspected cases had positive tests; two cases showed inconclusive results. Among controls, there was one false-positive (a CSF sample from a 5-year-old child with leukemia under treatment). The occurrence of a false positive in one of the negative control samples raises the possibility of the presence of interfering components in the CSF sample from patients with non-neurodegenerative pathologies. Our pilot results illustrate the feasibility of having CJD CSF samples tested in Brazilian centers and highlight the importance of interinstitutional collaboration to pursue a higher diagnostic accuracy in CJD in Brazil and Latin America.
- Neurologic adverse events of cancer immunotherapy(2022) BRITO, Marcelo Houat deCancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers. However, it is not without side effects. Several neurological adverse events have been recognized associated with immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T-cell therapy, the two main classes of cancer immunotherapy. With the increase in the prevalence of oncological diseases and this type of therapy, it is improbable that neurologists, oncologists, hematologists, and other healthcare professionals who deal with cancer patients will not encounter this type of neurologic complication in their practice in the following years.This article aims to review the epidemiology, clinical manifestations, diagnosis, and management of neurological complications associated with ICI and CAR T-cell therapy.
- [18F]FDG-PET in a case of right temporal lobe variant of frontotemporal dementia(2019) BRITO, Marcelo Houat de; TEIXEIRA, Thiago Bezerra Moraes; ZAMPIERI, Poliana Fonseca; COUTINHO, Artur Martins; BRUCKI, Sonia Maria Dozzi
- Teaching Video NeuroImages: Multisystemic Erdheim-Chester Disease Presenting as a Cerebellar Ataxia(2021) BRITO, Marcelo Houat de; OLIVEIRA, Marcos Castello Barbosa de; CASAL, Yuri Reis; ABDO, Andre Neder Ramires; LUCATO, Leandro Tavares; SIMABUKURO, Mateus Mistieri
- Three territory sign in cancer-related acute ischemic stroke(2020) BRITO, Marcelo Houat De; PIMENTEL, Gabriela Almeida; DOCEMA, Marcos Fernando de Lima; TRINDADE, Mateus Correa da