REBECA BOLTES CECATTO

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IRLM, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 27
  • article 12 Citação(ões) na Scopus
    Photodynamic therapy for squamous cell carcinoma of the head and neck: narrative review focusing on photosensitizers
    (2022) IBARRA, Ana Melissa Ccopa; CECATTO, Rebeca Boltes; MOTTA, Lara Jansiski; FRANCO, Adriana Lino dos Santos; SILVA, Daniela de Fatima Teixeira da; NUNES, Fabio Daumas; HAMBLIN, Michael R.; RODRIGUES, Maria Fernanda Setubal Destro
    This narrative review aimed to evaluate the effectiveness of PDT in early or advanced squamous cell carcinoma of the head and neck (SCCHN). Scopus, MEDLINE/PubMed, and Embase were searched electronically following the PRISMA protocol. Quality assessment was performed according to JBI, NIH, and AMSTAR protocols. The main outcomes evaluated were treatment response, recurrence, survival, and adverse effects. A total of 49 articles met the search criteria: 43 case series, two cohort studies, two prospective before-after clinical trials, one systematic review, and one meta-analysis. Data from 2121 SCCHN patients were included. The response to PDT was variable according to the type of photosensitizer, tumor location, and tumor stage. In general, higher complete responses rated were observed in T1/T2 SCCHN, mainly with mTHPC-mediated PDT. With regard to T3/T4 or advanced SCCHN tumors, there is no compelling evidence suggesting the effectiveness of PDT. Any adverse effects reported were well tolerated by patients. The present review suggests that PDT is a promising treatment modality for early-stage SCCHN. Although there are limitations due to the low level of evidence of the included studies, we believe that the present review could help to design robust clinical trials to determine the efficacy of PDT in SCCHN.
  • bookPart
    Reabilitação de Pacientes Oncológicos
    (2016) BRITO, Christina May Moran de; CECATTO, Rebeca Boltes; BATTISTELLA, Linamara Rizzo
  • bookPart
    Envelhecimento, Deficiência e Reabilitação
    (2016) IMAMURA, Marta; CECATTO, Rebeca Boltes; BATTISTELLA, Linamara Rizzo
  • bookPart
    Cuidados e intervenções em pacientes com metástase óssea
    (2014) SILVA, Adriana Marques da; SOUSA, Angela Maria; VASCONCELOS, Karina Gondim Moutinho da Conceição; ALMEIDA, Luciana Alexandra Antônia de; CORREIA, Luiz Filipe Marques; ANDRADE, Lydia Caldeira Tavares de Oliveira; DIZ, Maria Del Pilar Estevez; SOARES, Melissa Wilhelm; CECATTO, Rebeca Boltes; ANDRADE, Rodrigo Guimarãesde; TEIXEIRA, William Gemio Jacobsen
  • article 51 Citação(ões) na Scopus
    Methylene blue mediated antimicrobial photodynamic therapy in clinical human studies: The state of the art
    (2020) CECATTO, Rebeca Boltes; MAGALHAES, Lais Siqueira de; RODRIGUES, Maria Fernanda Setubal Destro; PAVANI, Christiane; LINO-DOS-SANTOS-FRANCO, Adriana; GOMES, Mariana Teixeira; SILVA, Daniela Fatima Teixeira
    Background: The goal of this study was to update the information about aPDT when using methylene blue (MB) for the treatment of human clinical infections of different etiologies, except for dentistry applications, and to also investigate the best parameters of MB to achieve this. Methods: This study was a systematic literature review performed according to the PRISMA guidelines. A literature search was performed for studies with adult human patients (>18 years-old) published in the English, French, Spanish, Portuguese, and Italian languages when using the electronic databases of MEDLINE, Embase, OpenGrey, and LILACS. Results: 1260 relevant articles were found. After a reading of the titles and the abstracts, only 85 articles were selected for a complete reading. After the complete reading, only 05 studies were selected for data extraction, where the treatments were onychomycosis, oral candidiasis, and infectious diabetic foot ulcers. As for the MB concentrations, 0.0003 to 0.06 molar were used. Pre-irradiation times ranged from 1 to 5 min, while the irradiation times ranged from 8 s to 10 min. As for the light sources, lasers, LED, and lamps were used, with irradiances ranging from 50 to 750 mW/cm(2) and radiant exposures from 6 to 18 J/cm(2). Conclusions: For the field of clinical applications of aPDT to develop, studies with a higher level of evidence are needed. For example, future reports should aim at comparing aPDT directly with standard techniques and a placebo aPDT, together with larger samples, and with more objective clinical evaluation methods, in order to provide useful data for the clinically relevant aPDT protocols.
  • bookPart
    Uso de meios físicos
    (2014) BUENO, Camila da Silva; VELAR, Camila Molina; BRITO, Christina May Moran de; KIKUTI, Karina Yoshie; CECATTO, Rebeca Boltes
  • bookPart
  • article 3 Citação(ões) na Scopus
    Acupuncture for Climacteric-Like Symptoms in Breast Cancer Improves Sleep, Mental and Emotional Health: A Randomized Trial
    (2022) D'ALESSANDRO, Eduardo Guilherme; SILVA, Alexandre Valotta da; CECATTO, Rebeca Boltes; BRITO, Christina May Moran de; AZEVEDO, Raymundo Soares; LIN, Chin An
    Objective: Breast cancer is the most prevalent malignant neoplasm in women. Optimal treatment frequently includes a hormonal-blockage phase maintained for 5-10 years. Pharmacologic agents used for this blockage induce many climacteric-like symptoms, which often exact a heavy toll on patients' quality of life. Acupuncture has had promising results for treating climacteric-like symptoms induced by hormonal blockage, but there is no evidence of efficacy for controlling hot flashes.Materials and Methods: This trial used acupuncture to treat the climacteric-like symptoms of patients with breast cancer, focusing on the mental, physical, and genitourinary symptoms and sleep disturbances, to determine the influence of acupuncture treatment. The randomized placebo-controlled trial, at a university-based cancer center, with blinded data collectors, compared an Acupuncture group (A), a Sham-Acupuncture group (S), and a Wait-List Control group (C). The patients were receiving tamoxifen. Group A had 10 weekly sessions of manual Acupuncture; Group S had 10 weekly sessions of Sham Acupuncture; and Group C spent 10 weeks on a Wait-List. The main outcome measures were the Beck Depression Inventory-II (BDI-II), the Pittsburgh Sleep Quality Index (PSQI), and the Menopause Rating Scale (MRS).Results: Primary analysis revealed differences among the groups' improvements in scores for the 3 questionnaires (P < 0.001), The A group had significant improvements on the BDI-II (P < 0.001), PSQI (P < 0.002), and MRS (P < 0.004) compared to the S group in a post hoc analysis.Conclusions: Acupuncture improved sleep, and mental and emotional distress symptoms induced by hormonal blockage in patients with breast cancer.
  • conferenceObject
    Rehabilitation in lung cancer
    (2013) BRITO, C. M. M.; ALMEIDA, E. M. P. de; SAUL, M.; CECATTO, R. B.; ANDRADE, R. G.; IMAMURA, M.; BATTISTELLA, L. R.
  • bookPart
    Intervenções de reabilitação no pós-operatório de pacientes ortopédicos
    (2014) VELAR, Camila Molina; REBOLLEDO, Daniel César Seguel; TOSCANO, Juliana Lopes; MOURãO, Marcelo Alves; CECATTO, Rebeca Boltes