MARIA FERNANDA VIANNA HUNZIKER
Índice h a partir de 2011
2
Projetos de Pesquisa
Unidades Organizacionais
PAHC, Hospital das Clínicas, Faculdade de Medicina - Médico
2 resultados
Resultados de Busca
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- Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease(2011) FERNANDES, Juliano Lara; SERRANO JR., Carlos Vicente; TOLEDO, Flavia; HUNZIKER, Maria Fernanda; ZAMPERINI, Augusto; TEO, Fabio H.; OLIVEIRA, Romulo T.; BLOTTA, Maria Heloisa; RONDON, Maria Urbana; NEGRAO, Carlos EduardoFew studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program. 34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that. In the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-gamma [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [-0.29 (0.84) mg/L vs. -0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively]. Chronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients.
- Actinomycetoma of the scalp due to Nocardia brasiliensis: case report and review of the literature(2015) ZUNIGA, Miguel; HUNZIKER, Maria Fernanda; NICO, Marcello Menta; RIVITTI, Evandro Ararigboia; FESTA-NETO, Cyro