PAULO ROBERTO DOS SANTOS SILVA
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject RESTING METABOLIC RATE AND WEIGHT LOSS AFTER BARIATRIC SURGERY Integrated Health/Multidisciplinary care(2017) MOTA, F.; CLEVA, R.; GADDUCCI, A.; CARDIA, L.; GREVE, J.; SILVA, P. R.; SANTO, M. A.conferenceObject LACTATE AS MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY Basic science and research in bariatric surgery(2019) VIEIRA, A. Gadducci; CARDIA, L.; OLIVEIRA, F. Costa De; MARIA, J. Greve De; SANTOS, P. Silva Roberto; PAJECKI, D.; AURELIO, M. Santo; CLEVA, R. De- Positive effects of football on fitness, lipid profile, and insulin resistance in Brazilian patients with type 2 diabetes(2014) SOUSA, M. V. de; FUKUI, R.; KRUSTRUP, P.; PEREIRA, R. M. R.; SILVA, P. R. S.; RODRIGUES, A. C.; ANDRADE, J. L. de; HERNANDEZ, A. J.; SILVA, M. E. R. daWe evaluated the effects of recreational football training combined with calorie-restricted diet (football+diet) vs calorie-restricted diet alone (diet) on aerobic fitness, lipid profile, and insulin resistance indicators in type 2 diabetes (T2D) patients. Forty-four T2D patients aged 48-68 years (27 females, 17 males) were randomly allocated to the football+diet group (FDG; n=22) or to the diet group (DG; n=22), of whom 19 FDG and 15 DG subjects completed the study. The football training was performed for 3x40min/week for 12 weeks. Dual-energy X-ray absorptiometry scanning, treadmill testing, and fasting blood samplings were performed pre and post-intervention. After 12 weeks, maximal oxygen uptake (VO2max) was elevated (P<0.05) by 10 +/- 4% in FDG but not in DG (-3 +/- 4%, P<0.05). After 12 weeks, reductions in blood triglycerides (0.4 +/- 0.1mmol/L), total cholesterol (0.6 +/- 0.2mmol/L), low-density lipoprotein, and very low-density lipoprotein levels were observed only in FDG. Fat mass decreased (P<0.05) by 3.4 +/- 0.4kg in FDG and 3.7 +/- 0.4kg in DG. The lower (P<0.05) glucagon and homeostatic model assessment of insulin resistance indicated an improvement in insulin sensitivity in FDG. In conclusion, football combined with restricted diet was effective in enhancing VO2max, reducing total cholesterol and triglycerides, and increasing insulin sensitivity, potentially providing better tools for the prevention of T2D complications than diet alone.
conferenceObject BODY COMPOSITION AND RESTING METABOLIC RATE IN WEIGHT LOSS AFTER BARIATRIC SURGERY(2016) SANTO, M. A.; MOTA, F. C.; V, A. Gadducci; SANTAREM, G. C.; SILVA, P. R.; GREVE, J.; CLEVA, R.- Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations(2016) SILVA, Leia Cristina Rodrigues; ARAUJO, Adriana Ladeira de; FERNANDES, Juliana Ruiz; MATIAS, Manuella de Sousa Toledo; SILVA, Paulo Roberto; DUARTE, Alberto J. S.; LEME, Luiz Eugenio Garcez; BENARD, GilStudies indicate that exercise might delay human biological aging, but the effects of long-term exercise on T cell function are not well known. We tested the hypothesis that moderate or intense exercise lifestyle may attenuate the effects of aging on the telomere length and the survival and composition of T cell subpopulations. Elderly (65-85 years) with intense training lifestyle (IT, n = 15), moderate training lifestyle (MT, n = 16), and who never trained (NT, n = 15) were studied. Although the three groups presented the ageassociated contraction of the TCD4(+)/TCD8(+) naive compartments and expansion of the memory compartments, both training modalities were associated with lower proportion of terminally differentiated (CD45RA(+) CCR7(neg)) TCD4 (+) and TCD8(+) cells, although among the latter cells, the reduction reached statistical significance only with IT. MT was associated with higher proportion of central memory TCD4(+) cells, while ITwas associated with higher proportion of effector memory TCD8(+) cells. However, both training lifestyles were unable to modify the proportion of senescent (CD28(neg)) TCD8(+) cells. Telomeres were longer in T cells in both training groups; with IT, telomere length increased mainly in TCD8(+) cells, whereas with MT, a modest increase in telomere length was observed in both TCD8(+) and TCD4(+) cells. Reduced commitment to apoptosis of resting T cells, as assessed by caspase-3 and Bcl-2 expression, was seen predominantly with IT. Measurement of pro-inflammatory cytokines in serum and peripheral blood mononuclear cell (PBMC)' s supernatants did not show chronic low-grade inflammation in any of the groups. In conclusion, MT and IT lifestyles attenuated some of the effects of aging on the immune system.
- Comparing the Aerobic Fitness of Professional Male Soccer Players and Soccer Referees(2019) SANTOS-SILVA, Paulo R.; GREVE, Julia M. D'Andrea; PEDRINELLI, Andre; ALMEIDA, Adriano M.; OSORIO, Bruna B.; FERREIRA, Marcelo; FERREIRA, CelsoWe looked to compare the aerobic performance between professional soccer referees and players. Fifty male soccer referees and 61 male soccer players were tested on a treadmill. The referees and players possessed 15 +/- 7 years and 7 +/- 3 years of experience in soccer, respectively. Significant differences were observed between the referees and players with regards to: age (34.8 +/- 4.6 years vs 20.8 +/- 2.7 years; P < 0.001, maximum oxygen uptake (54.7 +/- 5.4 mL center dot kg(-1)center dot min(-1) vs 58.8 +/- 4.4 mL center dot kg(-1)center dot min(-1); P < 0.001), and maximal heart rate in peak exercise (184 +/- 11 bpm vs 192 +/- 9 bpm, P < 0.001). Less significant differences also were observed and included; running speed at the maximum oxygen uptake (16.6 +/- 1 km center dot h(-1) vs 16.4 +/- 1.1 km center dot h(-1)), running speed at the ventilatory threshold (213.5 +/- 1.1 km center dot h(-1) vs 13.2 +/- 0.9 km center dot h(-1)), and percentage of maximal oxygen uptake at the ventilatory threshold (285.1% +/- 3.2% vs 84.1% +/- 6.2%). The effect size of most comparative variables between the two groups was small (<0.6). Older elite-level soccer referees are able to reach and maintain aerobic physical fitness levels similar to professional soccer players. Aerobic physical fitness may be a measurable factor for maintaining elite-level soccer licensure rather than age alone.
- Exergy efficiency on incremental stationary bicycle test: A new indicator of exercise performance?(2019) MADY, Carlos Eduardo Keutenedjian; IGARASHI, Tatiane Lie; ALBUQUERQUE, Cyro; SANTOS-SILVA, Paulo Roberto; FERNANDES, Tiago Lazzaretti; HERNANDEZ, Arnaldo JoseThe first and second laws of the thermodynamics were applied to the human body to evaluate the performance of subjects under different training levels. Ten cyclists were evaluated in the stationary bicycle with the indirect calorimetry analysis to obtain the metabolism on an energy and exergy basis. A distinguishing feature of this article is the evaluation of the exergy efficiency of the body with the knowledge of the real performed power and the internal temperature (measured tympanic temperature and calculated esophagus temperature). Regarding the skin temperature, an infrared camera was used to measure different parts of the body. Therefore, the phenomenological behavior of the body was assessed and used as a basis to apply the exergy analysis. Results indicate that the destroyed exergy can be an indicator of performance when compared with maximum oxygen consumption. Nevertheless, more experiments must be carried out to proper state if there is a correlation. Eventually, the exergy efficiency was calculated for all subjects, and its value was around 23 to 28%.
- The eight-week concurrent training effect on functional capacity in person living with unilateral transtibial amputation: A randomized controlled trial(2023) GRECCO, Marcus Vinicius; BRECH, Guilherme Carlos; CAMARGO, Cristina Pires; SANTOS-SILVA, Paulo Roberto; GREVA, Julia Maria D'AndreaIntroduction: The main causes of amputation include vascular diseases, trauma, cancer, and congenital limb abnormalities. The person with transtibial amputation (TA) is affected by a greater cardiorespiratory, metabolic, and muscular load to walk and perform daily activities. The sedentary lifestyle contributes to the process of chronic non-communicable diseases. The purpose of the study was to compare the effects of eight-week concurrent training (CT) for dependent variables as muscle strength, cardiorespiratory fitness, agility, and postural balance in persons with unilateral TA.Methods: A eight-week, randomized, controlled trial. Thirty-one people using prostheses for three or more months were selected. They were randomly divided into two groups: Experimental Group (EG; n = 17) -concurrent training and Control group (CG; n = 14) -no training. All patients were evaluated at the baseline and after eight weeks by the functional performance, isokinetic knee evaluation, static and dynamic posturography and cardiopulmonary test. Results: The patients showed improvements in all measures after training (size effect >0.80).Conclusion: The main limitations are the sample size, related to the socioeconomic status and availability training and no comparison to other types of training. Eight weeks of CT was effective and favorably modified the dependent variables in TA patients. Therefore, CT is a good option to improve functional performance after the regular rehabilitation program discharge and decreases the metabolic and func-tional deficits of these patients.(c) 2022 Elsevier Ltd. All rights reserved.
bookPart Teste ergoespirométrico(2016) FONSECA, Alfredo José da; FRIEDMANN, Antonio Américo; SILVA, Paulo Roberto SantosconferenceObject RESTING METABOLIC RATE AND BODY COMPOSITION AFTER 36 MONTHS OF BARIATRIC SURGERY Basic science and research in bariatric surgery(2019) VIEIRA, A. Gadducci; CARDIA, L.; SANTOS, P. Silva Roberto; ANDREA, J. Greve Maria D.; AURELIO, M. Santo; CLEVA, R. De