PAULO ROBERTO DOS SANTOS SILVA
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
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- Positive effects of football on fitness, lipid profile, and insulin resistance in Brazilian patients with type 2 diabetes(2014) SOUSA, M. V. de; FUKUI, R.; KRUSTRUP, P.; PEREIRA, R. M. R.; SILVA, P. R. S.; RODRIGUES, A. C.; ANDRADE, J. L. de; HERNANDEZ, A. J.; SILVA, M. E. R. daWe evaluated the effects of recreational football training combined with calorie-restricted diet (football+diet) vs calorie-restricted diet alone (diet) on aerobic fitness, lipid profile, and insulin resistance indicators in type 2 diabetes (T2D) patients. Forty-four T2D patients aged 48-68 years (27 females, 17 males) were randomly allocated to the football+diet group (FDG; n=22) or to the diet group (DG; n=22), of whom 19 FDG and 15 DG subjects completed the study. The football training was performed for 3x40min/week for 12 weeks. Dual-energy X-ray absorptiometry scanning, treadmill testing, and fasting blood samplings were performed pre and post-intervention. After 12 weeks, maximal oxygen uptake (VO2max) was elevated (P<0.05) by 10 +/- 4% in FDG but not in DG (-3 +/- 4%, P<0.05). After 12 weeks, reductions in blood triglycerides (0.4 +/- 0.1mmol/L), total cholesterol (0.6 +/- 0.2mmol/L), low-density lipoprotein, and very low-density lipoprotein levels were observed only in FDG. Fat mass decreased (P<0.05) by 3.4 +/- 0.4kg in FDG and 3.7 +/- 0.4kg in DG. The lower (P<0.05) glucagon and homeostatic model assessment of insulin resistance indicated an improvement in insulin sensitivity in FDG. In conclusion, football combined with restricted diet was effective in enhancing VO2max, reducing total cholesterol and triglycerides, and increasing insulin sensitivity, potentially providing better tools for the prevention of T2D complications than diet alone.
- Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations(2016) SILVA, Leia Cristina Rodrigues; ARAUJO, Adriana Ladeira de; FERNANDES, Juliana Ruiz; MATIAS, Manuella de Sousa Toledo; SILVA, Paulo Roberto; DUARTE, Alberto J. S.; LEME, Luiz Eugenio Garcez; BENARD, GilStudies indicate that exercise might delay human biological aging, but the effects of long-term exercise on T cell function are not well known. We tested the hypothesis that moderate or intense exercise lifestyle may attenuate the effects of aging on the telomere length and the survival and composition of T cell subpopulations. Elderly (65-85 years) with intense training lifestyle (IT, n = 15), moderate training lifestyle (MT, n = 16), and who never trained (NT, n = 15) were studied. Although the three groups presented the ageassociated contraction of the TCD4(+)/TCD8(+) naive compartments and expansion of the memory compartments, both training modalities were associated with lower proportion of terminally differentiated (CD45RA(+) CCR7(neg)) TCD4 (+) and TCD8(+) cells, although among the latter cells, the reduction reached statistical significance only with IT. MT was associated with higher proportion of central memory TCD4(+) cells, while ITwas associated with higher proportion of effector memory TCD8(+) cells. However, both training lifestyles were unable to modify the proportion of senescent (CD28(neg)) TCD8(+) cells. Telomeres were longer in T cells in both training groups; with IT, telomere length increased mainly in TCD8(+) cells, whereas with MT, a modest increase in telomere length was observed in both TCD8(+) and TCD4(+) cells. Reduced commitment to apoptosis of resting T cells, as assessed by caspase-3 and Bcl-2 expression, was seen predominantly with IT. Measurement of pro-inflammatory cytokines in serum and peripheral blood mononuclear cell (PBMC)' s supernatants did not show chronic low-grade inflammation in any of the groups. In conclusion, MT and IT lifestyles attenuated some of the effects of aging on the immune system.
- Effect of concurrent training in unilateral transtibial amputees using Paralympic athletes as a control group(2023) GRECCO, Marcus Vinicius; BRECH, Guilherme Carlos; SOARES-JUNIOR, Jose Maria; BARACAT, Edmund Chada; GREVE, Julia Maria D'Andrea; SILVA, Paulo Roberto SantosContext: Transtibial Amputation (TA) predisposes to a sedentary lifestyle.Objectives: To evaluate the efficiency of a short-term (8-week) Concurrent Training (CT) program in Unilateral Transtibial Amputees (UTA) and to compare it with the physical condition of a group of Paralympic athletes in preparation for the Rio de Janeiro Paralympics.Design: This was a longitudinal, prospective and controlled trial study.Methods: Thirty-four male subjects with UTA and using prostheses for six months or more were selected for this study. They were divided into two groups: Group 1 (G1) -17 non-athlete and untrained UTA and Group 2 (G2) -17 paralympic athletes with active UTA in the training phase. G1 was evaluated before and after eight weeks of CT and G2 made a single evaluation for control. All were submitted to anamnesis, clinical evaluation (blood pres-sure, electrocardiogram, and heart rate) and cardiopulmonary exercise testing on a lower limb cycle ergometer, and isokinetic knee dynamometry. The CT of G1 included resistance exercise and aerobic interval training on a stationary bicycle and G2 followed the training of the Paralympic teams.Results: Patients were retested by the same methods after CT. The two most important central dependent variables (maximal oxygen uptake and muscular strength) increased by 22% and knee extensor and flexor strength by 106% and 97%, respectively.Conclusion: After eight weeks of CT, there was an improvement in general functional condition, muscle strength, and cardiorespiratory performance improving protection against chronic diseases and quality of life.
- The eight-week concurrent training effect on functional capacity in person living with unilateral transtibial amputation: A randomized controlled trial(2023) GRECCO, Marcus Vinicius; BRECH, Guilherme Carlos; CAMARGO, Cristina Pires; SANTOS-SILVA, Paulo Roberto; GREVA, Julia Maria D'AndreaIntroduction: The main causes of amputation include vascular diseases, trauma, cancer, and congenital limb abnormalities. The person with transtibial amputation (TA) is affected by a greater cardiorespiratory, metabolic, and muscular load to walk and perform daily activities. The sedentary lifestyle contributes to the process of chronic non-communicable diseases. The purpose of the study was to compare the effects of eight-week concurrent training (CT) for dependent variables as muscle strength, cardiorespiratory fitness, agility, and postural balance in persons with unilateral TA.Methods: A eight-week, randomized, controlled trial. Thirty-one people using prostheses for three or more months were selected. They were randomly divided into two groups: Experimental Group (EG; n = 17) -concurrent training and Control group (CG; n = 14) -no training. All patients were evaluated at the baseline and after eight weeks by the functional performance, isokinetic knee evaluation, static and dynamic posturography and cardiopulmonary test. Results: The patients showed improvements in all measures after training (size effect >0.80).Conclusion: The main limitations are the sample size, related to the socioeconomic status and availability training and no comparison to other types of training. Eight weeks of CT was effective and favorably modified the dependent variables in TA patients. Therefore, CT is a good option to improve functional performance after the regular rehabilitation program discharge and decreases the metabolic and func-tional deficits of these patients.(c) 2022 Elsevier Ltd. All rights reserved.
- BONE MINERAL DENSITY AND BODY COMPOSITION IN ELDERLY RUNNERS: SIX-YEAR FOLLOW-UP(2019) ALONSO, Angelica Castilho; ERNANDES, Rita de Cassia; PEREIRA, Regina Helena Marques; BECKER, Ricardo Andre; MACHADO-LIMA, Adriana; SILVA-SANTOS, Paulo Roberto; GREVE, Julia Maria D'Andrea; GARCEZ-LEME, Luiz EugenioObjective: To evaluate bone mineral density (BMD) and body composition over a six-year period in elderly long-distance runners. Methods: We analyzed the medical records of elderly athletes who were long-distance runners, were participants of the IOT-HCFMUSP Orthogeriatric Group, and had their BMD evaluated between 2001 and 2007; of these athletes, 11 were included in the study. Inclusion criteria: athletes should be long-distance runners, should not stop long-distance running during the six-year period, and should have undergone BMD and body composition evaluations. Body composition was evaluated using bone densitometry with dual-energy X-ray absorptiometry with a Lunar-DPX device. Results: Over the six-year period, body composition remained stable, but there was a significant increase only in the fat percentage (p = 0.003). Conclusion: Long-distance running may maintain BMD but may lead to an increase in the fat percentage in elderly runners.
- Effect of 12-week rehearsal on cardiorespiratory fitness and body composition in Brazilian samba dancers(2023) DUARTE, Cicera Claudinea; SANTOS-SILVA, Paulo Roberto; PALUDO, Ana Carolina; GRECCO, Marcus Vinicius; GREVE, Julia Maria D'AndreaObjective: To investigate the effect of 12 weeks of rehearsals on cardiorespiratory parameters and body composition in Brazilian samba dancers belonging to a first-league samba school.Methods: Twenty-six women were divided into a Samba Group (n=13) and a Control Group (n=13). Cardiorespiratory parameters (cardiopulmonary exercise test) and body composition (skinfold assessment) were assessed before and after the 12 weeks of rehearsals. The Samba Group rehearsed three times per week for 30-60 minutes, and the Control Group participated in no physical activity. A comparison test was performed within and between groups, with p<0.05 indicating statistical significance.Results: Compared with the Control Group, the Samba Group showed a significant increase in maximal oxygen uptake (19%), oxygen pulse (13%), and lean body mass (3%) and a decrease in body fat percentage (11%) and fat mass (12%).Conclusion: Twelve weeks of samba dance rehearsals improved the cardiorespiratory and body composition parameters in women dancers compared with the Control Group. These findings suggest that dancing samba regularly can increase physical activity levels and positively affect the health parameters of samba dancers.