GUSTAVO BORGES DA SILVA TELES
Índice h a partir de 2011
3
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
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bookPart Doenças das vias aéreas(2017) TELES, Gustavo Borges da Silva- Performance of Chest Computed Tomography in Differentiating Coronavirus Disease 2019 From Other Viral Infections Using a Standardized Classification(2021) TELES, Gustavo Borges da Silva; FONSECA, Eduardo Kaiser Ururahy Nunes; YOKOO, Patricia; SILVA, Murilo Marques Almeida; YANATA, Elaine; SHOJI, Hamilton; PASSOS, Rodrigo Bastos Duarte; CHATE, Rodrigo Caruso; SZARF, GilbertoBackground: An expert consensus recently proposed a standardized coronavirus disease 2019 (COVID-19) reporting language for computed tomography (CT) findings of COVID-19 pneumonia. Purpose: The purpose of the study was to evaluate the performance of CT in differentiating COVID-19 from other viral infections using a standardized reporting classification. Methods: A total of 175 consecutive patients were retrospectively identified from a single tertiary-care medical center from March 15 to March 24, 2020, including 87 with positive reverse transcription-polymerase chain reaction (RT-PCR) test for COVID-19 and 88 with negative COVID-19 RT-PCR test, but positive respiratory pathogen panel. Two thoracic radiologists, who were blinded to RT-PCR and respiratory pathogen panel results, reviewed chest CT images independently and classified the imaging findings under 4 categories: ""typical"" appearance, ""indeterminate,"" ""atypical,"" and ""negative"" for pneumonia. The final classification was based on consensus between the readers. Results: Patients with COVID-19 were older than patients with other viral infections (P=0.038). The inter-rater agreement of CT categories between the readers ranged from good to excellent, kappa=0.80 (0.73 to 0.87). Final CT categories were statistically different among COVID-19 and non-COVID-19 groups (P<0.001). CT ""typical"" appearance was more prevalent in the COVID-19 group (64/87, 73.6%) than in the non-COVID-19 group (2/88, 2.3%). When considering CT ""typical"" appearance as a positive test, a sensitivity of 73.6% (95% confidence interval [CI]: 63%-82.4%), specificity of 97.7% (95% CI: 92%-99.7%), positive predictive value of 97% (95% CI: 89.5%-99.6%), and negative predictive value of 78.9% (95% CI: 70%-86.1%) were observed. Conclusion: The standardized chest CT classification demonstrated high specificity and positive predictive value in differentiating COVID-19 from other viral infections when presenting a ""typical"" appearance in a high pretest probability environment. Good to excellent inter-rater agreement was found regarding the CT standardized categories between the readers.
conferenceObject Evaluation and correlations of the extension of pulmonary cysts in lymphangioleiomyomatosis(2013) ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; BALDI, Bruno Guedes; TELES, Gustavo Borges da Silva; PIMENTA, Suzana Pinheiro; PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; COSTA, Andre Nathan; KAWANO-DOURADO, Leticia; KAWASSAKI, Alexandre; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto RibeirobookPart Infecções pulmonares(2017) TELES, Gustavo Borges da Silva; CHATE, Rodrigo Caruso; FUNARI, Marcelo Buarque de Gusmão- Evaluation of the Extent of Pulmonary Cysts and Their Association with Functional Variables and Serum Markers in Lymphangioleiomyomatosis (LAM)(2014) BALDI, Bruno Guedes; ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; TELES, Gustavo Borges da Silva; KAIRALLA, Ronaldo Adib; DIAS, Olivia Meira; PEREIRA, Daniel Antunes Silva; PIMENTA, Suzana Pinheiro; CARVALHO, Carlos Roberto RibeiroAlthough computed tomography (CT) has been used previously to assess disease severity in lymphangioleiomyomatosis (LAM), the associations between the extent of pulmonary cysts on CT and six-minute walk test (6MWT), matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF-D) are not well established. We performed a cross-sectional study to quantify the extent of pulmonary cysts in CT and to establish their correlations with pulmonary function tests (PFTs), 6MWT results, including a composite index (desaturation-distance ratio, DDR), and levels of VEGF-D and MMPs in LAM. Twenty-three LAM patients underwent CT scanning to automatically quantify the extent of pulmonary cysts and performed PFTs and 6MWT. Serum levels of MMP-2, MMP-9, and VEGF-D were also measured. The severity of pulmonary cystic involvement was mild (the extent of cysts was 6.8 %) and correlated best with FEV1/FVC (r = -0.84), residual volume (r = 0.66), DLCO (r = -0.82), the DDR index (r = 0.77), and desaturation during the 6MWT (r = -0.81). There was a weak correlation with VEGF-D (r = 0.45), but no association was found with MMP-2 and MMP-9. The severity of pulmonary cystic involvement was mild in this sample of LAM patients and correlated best with airway obstruction, air trapping, reduced DLCO, the DDR index, and desaturation during the 6MWT. Serum VEGF-D cannot be completely defined as a valuable marker of disease severity and there may be a mechanism independent of MMPs to explain the formation of pulmonary cysts.
conferenceObject Coronary Artery Disease, Epicardial Adipose Tissue and Perioperative Risk in Patients Undergoing Abdominal Aortic Aneurysm Repair Surgery(2019) RODRIGUES, Caio Vinicius F.; TELES, Gustavo; WANDERLEY, Mark; CARDOZO, Francisco M. Malta; YU, Pai C.; GUALANDRO, Danielle; CASELLA, Ivan B.; SILVA, Erasmo; CARAMELLI, Bruno; CALDERARO, Daniela- Traqueobronquite aguda causada por Aspergillus: relato de caso e achados de imagem(2014) NISHIYAMA, Katia Hidemi; FALCÃO, Esther de Alencar Aripe; KAY, Fernando Uliana; TELES, Gustavo Borges Silva; BERNARDI, Fabiola Del Carlo; FUNARI, Marcelo Buarque de GusmãoAcute tracheobronchitis is a rare manifestation of invasive aspergillosis, generally occurring in severely immunocompromised patients. The authors report the case of a patient presenting with this condition after bone-marrow transplantation, with emphasis on tomographic findings.
conferenceObject Pulmonary Cystic Quantification In Lam: Assessment Of Disease Severity And Its Association With Pulmonary Function Tests And Serum Markers(2014) ARAUJO, M. S.; BALDI, B. G.; FREITAS, C. S. G.; TELES, G. B. D. S.; PIMENTA, S. P.; DIAS, O. M.; PEREIRA, D. A. S.; KAIRALLA, R. A.; CARVALHO, C. R. R.