ROBERTA DIEHL RODRIGUEZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
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- Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country(2022) SUEMOTO, Claudia K.; BERTOLA, Laiss; GRINBERG, Lea T.; LEITE, Renata E. P.; RODRIGUEZ, Roberta D.; SANTANA, Pedro H.; PASQUALUCCI, Carlos A.; JACOB-FILHO, Wilson; NITRINI, RicardoIntroduction Education, and less frequently occupation, has been associated with lower dementia risk in studies from high-income countries. We aimed to investigate the association of cognitive impairment with education and occupation in a low-middle-income country sample. Methods In this cross-sectional study, cognitive function was assessed by the Clinical Dementia Rating sum of boxes (CDR-SOB). We investigated the association of occupation complexity and education with CDR-SOB using adjusted linear regression models for age, sex, and neuropathological lesions. Results In 1023 participants, 77% had < 5 years of education, and 56% unskilled occupations. Compared to the group without education, those with formal education had lower CDR-SOB (1-4 years: beta= -0.99, 95% confidence interval [CI] = -1.85; -0.14, P = .02; >= 5 years: beta= -1.42, 95% CI = -2.47; -0.38, P = .008). Occupation complexity and demands were unrelated to cognition. Discussion Education, but not occupation, was related to better cognitive abilities independent of the presence of neuropathological insults.
- Neuropathological correlates of neuropsychiatric symptoms in dementia(2023) GIBSON, Lucy L.; GRINBERG, Lea T.; FFYTCHE, Dominic; LEITE, Renata E. P.; RODRIGUEZ, Roberta D.; FERRETTI-REBUSTINI, Renata E. L.; PASQUALUCCI, Carlos A.; NITRINI, Ricardo; JACOB-FILHO, Wilson; AARSLAND, Dag; SUEMOTO, Claudia K.Introduction Neuropsychiatric symptoms (NPS) are common in Lewy body disease (LBD), but their etiology is poorly understood. Methods In a population-based post mortem study neuropathological data was collected for Lewy body (LB) neuropathology, neurofibrillary tangles (NFT), amyloid beta burden, TDP-43, lacunar infarcts, cerebral amyloid angiopathy (CAA), and hyaline atherosclerosis. Post mortem interviews collected systematic information regarding NPS and cognitive status. A total of 1038 cases were included: no pathology (NP; n = 761), Alzheimer's disease (AD; n = 189), LBD (n = 60), and AD+LBD (n = 28). Results Hallucinations were associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms in the Neuropsychiatric Inventory. Cases with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms but a multiplicative interaction between these pathologies was not significant. Discussion LB and AD pathology contribute differentially to NPS likely with an additive process contributing to the increased burden of NPS.
- Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery(2017) THEOFILAS, Panos; EHRENBERG, Alexander J.; DUNLOP, Sara; ALHO, Ana T. Di Lorenzo; NGUY, Austin; LEITE, Renata Elaine Paraizo; RODRIGUEZ, Roberta Diehl; MEJIA, Maria B.; SUEMOTO, Claudia K.; FERRETTI-REBUSTINI, Renata Eloah De Lucena; POLICHISO, Livia; NASCIMENTO, Camila F.; SEELEY, William W.; NITRINI, Ricardo; PASQUALUCCI, Carlos Augusto; JACOB FILHO, Wilson; RUEB, Udo; NEUHAUS, John; HEINSEN, Helmut; GRINBERG, Lea T.Introduction: Alzheimer's disease (AD) progression follows a specific spreading pattern, emphasizing the need to characterize those brain areas that degenerate first. The brainstem's locus coeruleus (LC) is the first area to develop neurofibrillary changes (neurofibrillary tangles [NFTs]). Methods: The methods include unbiased stereologiCal analyses in human brainstems to estimate LC volume and neuronal population in controls and individuals across all AD stages. Results: As the Braak stage increases by 1 unit, the LC volume decreases by 8.4%. Neuronal loss started only midway through AD progression. Age-related changes spare the LC. Discussion: The long gap between NFT accumulation and neuronal loss suggests that a second trigger may be necessary to induce neuronal death in AD. Imaging studies should determine whether LC volumetry can replicate the stage-wise atrophy observed here and how these changes are specific to AD. LC volumetry may develop into a screening biomarker for selecting high-yield candidates to undergo expensive and less accessible positron emission tomography scans and to monitor AD progression from presymptomatic stages.
- Dementia in Latin America: Paving the way toward a regional action plan(2021) PARRA, Mario Alfredo; BAEZ, Sandra; SEDENO, Lucas; CAMPO, Cecilia Gonzalez; SANTAMARIA-GARCIA, Hernando; APRAHAMIAN, Ivan; BERTOLUCCI, Paulo H. F.; BUSTIN, Julian; BICALHO, Maria Aparecida Camargos; CANO-GUTIERREZ, Carlos; CARAMELLI, Paulo; CHAVES, Marcia L. F.; COGRAM, Patricia; BEBER, Barbara Costa; COURT, Felipe A.; SOUZA, Leonardo Cruz de; CUSTODIO, Nilton; DAMIAN, Andres; CRUZ, Myriam de la; RODRIGUEZ, Roberta Diehl; BRUCKI, Sonia Maria Dozzi; FAJERSZTAJN, Lais; FARIAS, Gonzalo A.; FELICE, Fernanda G. De; FERRARI, Raffaele; OLIVEIRA, Fabricio Ferreira de; FERREIRA, Sergio T.; FERRETTI, Ceres; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; FUENTES, Patricio; GARCIA, Adolfo M.; GARCIA, Patricia J.; PORTO, Fabio Henrique de Gobbi; PENAILILLO, Lissette Duque; ENGLER, Henry Willy; MAIER, Irene; MATA, Ignacio F.; GONZALEZ-BILLAULT, Christian; LOPEZ, Oscar L.; MORELLI, Laura; NITRINI, Ricardo; QUIROZ, Yakeel T.; BARRAGAN, Alejandra Guerrero; HUEPE, David; PIO, Fabricio Joao; SUEMOTO, Claudia Kimie; KOCHHANN, Renata; KOCHEN, Silvia; KUMFOR, Fiona; LANATA, Serggio; MILLER, Bruce; MANSUR, Leticia Lessa; HOSOGI, Mirna Lie; LILLO, Patricia; GUERRA, Jorge Llibre; LIRA, David; LOPERA, Francisco; COMAS, Adelina; AVILA-FUNES, Jose Alberto; SOSA, Ana Luisa; RAMOS, Claudia; RESENDE, Elisa de Paula Franca; SNYDER, Heather M.; TARNANAS, Ioannis; YOKOYAMA, Jenifer; LLIBRE, Juan; CARDONA, Juan Felipe; POSSIN, Kate; KOSIK, Kenneth S.; MONTESINOS, Rosa; MOGUILNER, Sebastian; SOLIS, Patricia Cristina Lourdes; FERRETTI-REBUSTINI, Renata Eloah de Lucena; RAMIREZ, Jeronimo Martin; MATALLANA, Diana; MBAKILE-MAHLANZA, Lingani; TON, Alyne Mendonca Marques; TAVARES, Ronnielly Melo; MIOTTO, Eliane C.; MUNIZ-TERRERA, Graciela; MUNOZ-NEVAREZ, Luis Arnoldo; OROZCO, David; OLIVEIRA, Maira Okada de; PIGUET, Olivier; CAIPA, Maritza Pintado; ESCUDERO, Stefanie Danielle Pina; SCHILLING, Lucas Porcello; PALMEIRA, Andre Luiz Rodrigues; YASSUDA, Monica Sanches; SANTACRUZ-ESCUDERO, Jose Manuel; SERAFIM, Rodrigo Bernardo; SMID, Jerusa; SLACHEVSKY, Andrea; SERRANO, Cecilia; SOTO-ANARI, Marcio; TAKADA, Leonel Tadao; GRINBERG, Lea Tenenholz; TEIXEIRA, Antonio Lucio; BARBOSA, Maira Tonidandel; TREPEL, Dominic; IBANEZ, AgustinAcross Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.