LUCIO GARCIA DE OLIVEIRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/40 - Laboratório de Imunohematologia e Hematologia Forense, Hospital das Clínicas, Faculdade de Medicina
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- In-transition culture of experimentation with cannabis in Latin American college students: A new role within a potential drug use sequencing pattern(2018) CASTALDELLI-MAIA, Joao Mauricio; NICASTRI, Sergio; CERDA, Magdalena; KIM, June H.; OLIVEIRA, Lucio Garcia de; ANDRADE, Arthur Guerra de; MARTINS, Silvia S.Introduction and AimsGiven a scenario of intense discussion about the legal situation of cannabis users worldwide, this paper aims to investigate the role of cannabis within a drug use sequencing pattern. Design and MethodsData came from a representative sample of college students from 27 Brazilian capitals (n=12711). We analysed the patterns of transition from/to the first use of cannabis to/from the first use of alcohol, tobacco and seven other illegal drugs. Survival analysis methods were used to analyse age of onset data on all potential drug pairs. Drugs that were not specified as the target drug pair tested in each survival model were included as time-varying covariates in all models. ResultsWe found significant transitions from alcohol [adjusted hazard ratio (aHR)=1.41, 95% confidence interval (CI) 1.15-1.73, P<0.001] and inhalants (aHR=1.56, 95% CI 1.26-1.93, P<0.001) to cannabis. Moreover, we found significant transitions from cannabis to alcohol (aHR=2.40, 95% CI 1.47-3.91, P<0.001), cocaine (aHR=7.47, 95% CI=4.26-13.09, P<0.001), prescription opioids (aHR=2.16, 95% CI 1.29-3.63, P<0.01) and tranquilisers (aHR=1.51, 95% CI 1.11-2.06, P<0.01). Discussion and ConclusionsOverall, our findings point to a strategic role of cannabis within drug first use sequence pattern. We had an important and unexpected findingthe bi-directional relationship between alcohol and cannabis. In addition, the first use of cannabis still precedes the first use of cocaine and non-medical use of tranquilisers and prescription opioids. [Castaldelli-Maia JM, Nicastri S, Cerda M, Kim JH, Oliveira LG, Andrade AG, Martins, SS. In-transition culture of experimentation with cannabis in Latin American college students: A new role within a potential drug use sequencing pattern. Drug Alcohol Rev 2017;00:000-000]
- A continuidade do uso de anfetaminas por motoristas de caminhão no Estado de São Paulo, Brasil, a despeito da proibição de sua produção, prescrição e uso(2013) OLIVEIRA, Lucio Garcia de; ENDO, Ligia Goes; SINAGAWA, Daniele Mayumi; YONAMINE, Mauricio; MUNOZ, Daniel Romero; LEYTON, VilmaAmphetamine use by truck drivers for occupational purposes is widely known. The production and consumption of amphetamines was banned by the Brazilian National Health Surveillance Agency (ANVISA) in October 2011. This study analyzes persistent amphetamine use by truck drivers since the ban was implemented. A convenience sample of 427 truck drivers was taken along highways in Sao Paulo State in 2012. Participants were asked to answer a structured questionnaire and provide a urine sample to screen for recent amphetamine consumption through toxicological analysis. Among the interviewed drivers, 7% had used some illicit drug recently and 2.7% had used amphetamines. Amphetamines are still consumed by truck drivers despite the risks and the recent ban. The authorities should thus monitor the possession and use of amphetamines by drivers in order to effectively enforce the ban.
- Attention performance among Brazilian truck drivers and its association with amphetamine use: pilot study(2013) OLIVEIRA, Lucio Garcia de; SANTOS, Bernardo dos; GONCALVES, Priscila Dib; CARVALHO, Heraclito de Barbosa; MASSAD, Eduardo; LEYTON, VilmaThe aim of this article was to describe the attention functioning of twenty-two truck drivers and its relationship with amphetamine use. Those drivers who reported using amphetamines in the twelve months previous to the interview had the best performance in a test evaluating sustained attention functioning. Although amphetamine use may initially seem advantageous to the drivers, it may actually impair safe driving. The findings suggest the importance of monitoring the laws regarding amphetamine use in this country.
- Use of Alcohol Mixed with Energy Drinks Increases the Prevalence of Driving Violations among Brazilian Truck Drivers(2020) OLIVEIRA, Lucio Garcia de; ECKSCHMIDT, Frederico; LEYTON, Vilma; CARVALHO, Heraclito Barbosa deBackground: The use of alcohol mixed with energy drinks (AmED) has been reported to be associated with a variety of unsafe driving practices. Truck drivers are vulnerable to driving violations, particularly because of their engagement in drug use. The use of AmED among these professionals remains unknown. Aim: To estimate the prevalence of AmED use and its association with driving violations among truck drivers. Methods: 684 drivers were recruited in Sao Paulo, Brazil. The use of drugs was reported. Drivers were split into three groups: (a) alcohol abstainers (AA); (b) alcohol-only users (AO); and (c) users of AmED. Intergroup comparisons were performed by polynomial logistic regression (the reference category was AO). We also performed Poisson regression analysis to obtain the prevalence ratio; the significance level was stipulated at 5%. Results: The prevalence of drivers reporting the use of AmED was 16.8%. Users of AmED (a) were younger, (b) were less experienced drivers, (c) had a heavier pattern of alcohol use, (d) used illicit drugs more frequently, and (e) had poorer sleep quality than AO subjects. A higher prevalence of drivers who had arguments or fights while driving (PR = 1.71) and of drivers who drove unbelted (PR = 1.66) ingested AmED than of AO subjects. Conclusions/importance: The use of AmED increased the prevalence of driving violations beyond the risks commonly attributed to alcohol use. We suggest additional investments in preventative measures based on the beverage category and a revision of the work organization of truck drivers to reduce their health and social risks.
- Prevalence of at-risk drinking among Brazilian truck drivers and its interference on the performance of executive cognitive tasks(2016) OLIVEIRA, Lucio Garcia de; LEOPOLDO, Kae; GOUVEA, Marcela Julio Cesar; BARROSO, Lucia Pereira; GOUVEI, Paula Adriana Rodrigues; MUNOZ, Daniel Romero; LEYTON, VilmaBackground: Binge drinking (BD) has been associated with an increase in the risk of alcohol-related injuries. Alcohol continues to be the main substance consumed by truck drivers, a population of special concern, since they are often involved in traffic accidents. The aim of this study was to estimate the prevalence of BD and its interference in the executive functioning among truck drivers in Sao Paulo, Brazil. Methods: A non-probabilistic sample of 684 truck drivers was requested to answer a structured research instrument on their demographic data and alcohol use. They performed cognitive tests to assess their executive functioning and inventories about confounding variables. The participants were then divided according to their involvement in BD. Results: 17.5% of the interviewees have reported being engaged in BD. Binge drinkers showed a better performance on one test, despite having done so at the expense of more mistakes and lower accuracy. More interestingly, binge drinkers took three seconds longer than non-binge drinkers to inhibit an inadequate response, which is worrisome in the context of traffic. Overall, the deleterious effect of BD on performance remained after controlling for the effects of confounding variables in regression logistic models. Conclusions: As the use of alcohol among truck drivers may be as a way to get by with their work conditions, we believe that a negotiation between their work organization and public authorities would reduce such use, preventing negative interferences on truck drivers' cognitive functioning, which by its turn may also prevent traffic accidents.
- Alcohol and other drug use by Brazilian truck drivers: a cause for concern?(2012) OLIVEIRA, Lucio Garcia de; YONAMINE, Mauricio; ANDREUCCETI, Gabriel; PONCE, Julio de Carvalho; LEYTON, Vilma
- Comparação do uso de drogas entre universitários brasileiros, norte-americanos e jovens da população geral brasileira(2013) ECKSCHMIDT, Frederico; ANDRADE, Arthur Guerra de; OLIVEIRA, Lúcio Garcia deOBJECTIVE: To compare drug use between college students and the general Brazilian population, as well as with American college students' drug use, identifying possible usage differences related to cultural interference. METHODS: To compare lifetime drug use between target populations, public data collected from statistical surveys conducted with Brazilian college students and the general population were used, as well as surveys conducted with American college students. The surveys' confidence intervals (95% CI) were subjects of comparison. RESULTS: Drug use is more frequent among American college students, who use more tobacco, tranquilizers, marijuana, ecstasy, hallucinogens, cocaine, crack cocaine and heroin than Brazilian college students. In contrast, Brazilian college students use nearly the double of inhalants than American college students. This pattern of use is repeated in the analysis of intra-gender differences. Add to this that Brazilian college students seem to engage more frequently in drinking alcoholic beverages and using marijuana, tranquilizers, inhalants, hallucinogens and amphetamines than their peers in the general Brazilian population. CONCLUSIONS: Knowing the particularities of drug use among college students is of paramount importance for the early detection of consumption. Investments in this segment and gender differences should be considered in preventive policies, as well as developing strategies of consumption reduction and control, such as screening programs and brief intervention, due to better cost-effectiveness.
- The role of drug use sequencing pattern in further problematic use of alcohol, tobacco, cannabis, and other drugs(2015) CASTALDELLI-MAIA, Joao Mauricio; MARTINS, Silvia S.; OLIVEIRA, Lucio Garcia de; ANDRADE, Arthur Guerra de; NICASTRI, SergioBackground: There has been considerable debate regarding what typically occurs after experimentation with drugs throughout the life of young people who used various drugs. Aims: To evaluate the clinical importance of the most common sequence for the first use of a drug by two models (the ""gateway model'' and the ""alternative model'', which is the most popular sequence for Brazilian university students according to a previous study) regarding the problematic use of alcohol, tobacco, cannabis and other illegal drugs, assessed by ASSIST. Method: People who had already experimented with three or more drugs across different stages of the two models were selected from a representative sample of university students from 27 Brazilian capitals (n = 12 711). Findings: There were no differences regarding the problematic use of the most consumed drugs in Brazil (alcohol, tobacco and cannabis) between the models. Multiple drug seekers and violators had more problematic use of illegal drugs other than cannabis than individuals in the model sequence. However, in the case of violators, this was only evident in the alternative model. Conclusions: Multiple drug seekers and violators deserve special attention due to their increased risk of problematic use of other illegal drugs.
- Uso de anfetaminas por motoristas de caminhão em rodovias do Estado de São Paulo: um risco à ocorrência de acidentes de trânsito?(2013) TAKITANE, Juliana; OLIVEIRA, Lucio Garcia de; ENDO, Ligia Goes; OLIVEIRA, Keziah Cristina Barbosa Gruber de; MUNOZ, Daniel Romero; YONAMINE, Mauricio; LEYTON, VilmaThe use of amphetamines in Brazil is common among truck drivers, which may be an important factor in the occurrence of traffic accidents. This article seeks to estimate the prevalence of amphetamine use among truck drivers. Drivers (N = 134) were stopped on two different highways in Sao Paulo state and they were asked to answer a questionnaire and provide a urine sample for toxicological analysis. All data were analyzed on Stata 8.0. All participants were males with low levels of schooling, whose mean age was 40.8 years. The presence of amphetamines was detected in 10.8% of all urine samples collected, being commonly justified in order to make truck drivers able to maintain their state of awareness. Amphetamine use was detected among truck drivers on Sao Paulo highways. The problem is that when the stimulant effects wear off, sleepiness due to sleep deprivation reduces concentration and good driver performance, making drivers vulnerable to traffic accidents and the related effects.
- Do varsity college athletes have a greater likelihood of risky alcohol and cannabis use than non-athletes? Results from a National Survey in Brazil(2022) MANNES, Zachary L.; HASIN, Deborah S.; MARTINS, Silvia S.; GONCALVES, Priscila D.; LIVNE, Ofir; OLIVEIRA, Lucio G. de; ANDRADE, Arthur G. de; MCREYNOLDS, Larkin S.; MCDUFF, David; HAINLINE, Brian; CASTALDELLI-MAIA, Joao M.Objective: We examined the prevalence of risky alcohol and cannabis use among Brazilian varsity college athletes and whether this group had a greater likelihood of risky use than non-athletes. Methods: In 2009, Brazilian college students (n=12,711) were recruited for a national stratified random survey. Their sociodemographic characteristics, mental health, substance use, and participation in varsity sports were assessed. Binary logistic regression models were used to examine the association between varsity athlete status and moderate to high-risk alcohol and cannabis use. Results: Among varsity athletes, 67.6 and 10.7% reported risky alcohol and cannabis use, respectively. Varsity athletes had greater odds of risky alcohol consumption than non-athletes (aOR = 2.02, 95%CI 1.08-3.78). Varsity athletes also had greater odds of risky cannabis use than non-athletes in unadjusted analyses (OR = 2.57, 95%CI 1.05-6.28), although this relationship was attenuated after covariate adjustment. Conclusions: Among college students in Brazil, varsity athletes had a higher prevalence of risky alcohol and cannabis use than non-athletes. The rates were considerably higher than those observed among samples of U.S. college athletes. Future research should examine the use of these substances among varsity college athletes in other middle-income countries since these findings will likely guide prevention and treatment efforts.
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