LANA MARIA DE AGUIAR
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
54 resultados
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bookPart Vulvovaginite em criança(2021) ALMEIDA, José Alcione Macedo; SCHAEFER, Mariana Soares Pereira; AGUIAR, Lana Maria debookPart Carcinoma de células escamosas da vulva(2013) PIRES, Fatima Moreno; AGUIAR, Lana Maria debookPart Sífilis(2015) ROA, Cristiane Lima; AGUIAR, Lana Maria debookPart Líquen esclerose vulvar em crianças: diagnóstico e tratamento(2016) ALMEIDA, José Alcione Macedo; JúNIOR, José Maria Soares; RAMOS, Laudelino de Oliveira; AGUIAR, Lana Maria debookPart Tumores da vulva na infância e na adolescência(2021) AGUIAR, Lana Maria de; MORAES, Andrea Sclowitz; ALMEIDA, José Alcione MacedobookPart Doença de Behçet(2015) WOJITANI, Maria Dulce Caoro Horie Wojitani; AGUIAR, Lana Maria de- Effects of Melatonin Alone or Associated with Acyclovir on the Suppressive Treatment of Recurrent Genital Herpes: A Prospective, Randomized, and Double-Blind Study(2023) ROA, Cristiane Lima; CIPOLLA-NETO, Jose; REITER, Russel J.; LINHARES, Iara Moreno; LEPIQUE, Ana Paula; AGUIAR, Lana Maria de; SEGANFREDO, Isadora Braga; FERREIRA-FILHO, Edson Santos; MEDEIROS, Sebastiao Freitas de; BARACAT, Edmund Chada; SOARES-JR, Jose MariaSuppressive therapy of recurrent genital herpes is a challenge, and melatonin may be an alternative. Objective: To evaluate the action of melatonin, acyclovir, or the association of melatonin with acyclovir as a suppressive treatment in women with recurrent genital herpes. Design: The study was prospective, double-blind, and randomized, including 56 patients as follows: (a) The melatonin group received 180 placebo capsules in the 'day' container and 180 melatonin 3 mg capsules in the 'night' container (n = 19); (b) The acyclovir group received 360 capsules of 400 mg acyclovir twice a day (one capsule during the day and another during the night) (n = 15); (c) the melatonin group received 180 placebo capsules in the 'day' container and 180 melatonin 3 mg capsules in the 'night' container (n = 22). The length of treatment was six months. The follow-up after treatment was six months. Patients were evaluated before, during, and after treatment through clinical visits, laboratory tests, and the application of four questionnaires (QSF-36, Beck, Epworth, VAS, and LANNS). Results: No statistically significant difference was observed for the depression and sleepiness questionnaires. However, in the Lanns scale for pain, all groups decreased the mean and median values in time (p = 0.001), without differentiation among the groups (p = 0.188). The recurrence rates of genital herpes within 60 days after treatment were 15.8%, 33.3%, and 36.4% in the melatonin, acyclovir, and association of melatonin with acyclovir groups, respectively. Conclusion: Our data suggest that melatonin may be an option for the suppressive treatment of recurrent genital herpes.
bookPart Doença Inflamatória Pélvica(2013) RONCAGLIA, Maria Teresa; MOTTA, Eduardo Vieira da; AGUIAR, Lana Maria debookPart Herpes genital na infância e na adolescência(2021) ROA, Cristiane Lima; LORENZI, Noely Paula Cristina; AGUIAR, Lana Maria de; ALMEIDA, José Alcione MacedobookPart Vulvodínia(2015) AGUIAR, Lana Maria de