THIAGO NUNES PEREIRA LEITE
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina
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- A prospective study of patients with refractory angina: outcomes and the role of high-sensitivity troponin T(2017) POPPI, Nilson T.; GOWDAK, Luis H. W.; DOURADO, Luciana O. C.; ADAM, Eduardo L.; LEITE, Thiago N. P.; MIOTO, Bruno M.; KRIEGER, Jose E.; CESAR, Luiz A. M.; PEREIRA, Alexandre C.BackgroundThe predictors of cardiovascular events in patients with chronic refractory angina are limited. High-sensitivity cardiac troponin T (hs-cTnT) assays are biomarkers that may be used to determine the prognosis of patients with stable coronary artery disease. HypothesisHs-cTnT is a predictor of death and nonfatal myocardial infarction (MI) in patients with refractory angina. MethodsWe prospectively enrolled 117 consecutive patients in this study. A heart team ruled out myocardial revascularization feasibility after assessing recent coronary angiograms; evidence of myocardial ischemia served as an inclusion criterion. Optimal medical therapy was encouraged via outpatient visits every 6 months; plasma hs-cTnT levels were determined at baseline. The primary endpoint was the composite incidence of death and nonfatal MI. ResultsDuring a median follow-up period of 28.0 months (interquartile range, 18.0-47.5 months), an estimated 28.0-month cumulative event rate of 13.4% was determined via the Kaplan-Meier method. Univariate predictors of the composite endpoint were hs-cTnT levels and LV dysfunction. Following a multivariate analysis, only hs-cTnT was independently associated with the events in question, either as a continuous variable (hazard ratio per unit increase in the natural logarithm: 2.83, 95% confidence interval: 1.62-4.92, P < 0.001) or as a categorical variable (hazard ratio for concentrations above the 99th percentile: 5.14, 95% confidence interval: 2.05-12.91, P < 0.001). ConclusionsIn patients with chronic refractory angina, plasma concentration of hs-cTnT is the strongest predictor of death and nonfatal MI. Notably, none of the outcomes in question occurred in patients with baseline plasma levels <5.0 ng/L.
- Male gender and smoking are related to single, but not to multiple, human aortic aneurysms(2015) GUTIERREZ, Paulo S.; LEITE, Thiago N. P.; MANGIONE, Fernanda M.There is scanty information concerning multiple aortic aneurysms. Thus, we verified if clinical or pathological characteristics are different in patients with multiple (two or more) aortic aneurysms in comparison with those with only one. Material and methods: We selected at the necropsy files of the Heart Institute, Sao Paulo University School of Medicine, the last 100 cases with aortic aneurysms, comparing between the two groups: sex, age, presence of systemic arterial hypertension, diabetes, dyslipedemia, history of smoking habit, cause of the aneurysm, cause of death, and if the diagnosis was reached during life. Age was analysed by Mann-Whitney test, and the other variables by chi-square or Fisher's exact test. Results: Multiple aneurysms corresponded to 14% of cases. The proportion of women among patients with multiple aneurysms was higher than among those with single aneurysm(64.3% versus 20.9%, P<.01), even if only cases with atherosclerosis were taken into consideration (women among multiple-6/10, 60.0%; among single-14/70, 20.0%; P=.01). Smoking was less reported in cases with multiple (4/14, 28.6%) than with single aneurysm (53/86, 61.6%; P=.04); considering cases with atherosclerosis, such difference decreases (40.0% of multiple versus 68.6% of single, P=.09). Conclusion: although atherosclerosis is present in most cases of both single and multiple aortic aneurysms, male gender and smoking, considered highly influential in such lesions, are less frequent in patients with multiple than in patients with single aneurysms. Thus mechanisms underlying multiple aortic aneurysms are probably different from those related to single, more common aneurysms.
bookPart Fibrilação atrial(2018) BASTOS FILHO, João Bosco Breckenfeld; LEITE, Thiago Nunes Pereira; DARRIEUX, Francisco Carlos da CostabookPart Fibrilação atrial(2018) BASTOS FILHO, João Bosco Breckenfeld; LEITE, Thiago Nunes Pereira; DARRIEUX, Francisco Carlos da CostabookPart Fibrilação atrial(2015) LEITE, Thiago Nunes Pereira; DARRIEUX, FranciscobookPart Fibrilação atrial(2015) LEITE, Thiago Nunes Pereira; DARRIEUX, FranciscoconferenceObject Predictors of death and myocardial infarction in patients with refractory angina(2014) POPPI, N. Tavares; DOURADO, L. O. C.; VENTURINI, G.; ADAM, E. L.; LEITE, T. N. P.; CESAR, L. A. Machado; PEREIRA, A. C.; GOWDAK, L. H. W.- Caso 05/12 – Mulher de 67 anos Portadora de Hipertensão Arterial e Fibrilação Atrial com Choque Seguido de Parada Cardíaca sem Pulso Dois Meses após Cirurgia para Correção de Aneurisma de Aorta Ascendente(2012) MANGIONE, Fernanda Marinho; LEITE, Thiago Nunes Pereira; GUTIERREZ, Paulo Sampaio