JOSE EDUARDO KRIEGER
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits(2021) SUN, D.; RICHARD, M. A.; MUSANI, S. K.; SUNG, Y. J.; WINKLER, T. W.; SCHWANDER, K.; CHAI, J. F.; GUO, X.; KILPELäINEN, T. O.; VOJINOVIC, D.; ASCHARD, H.; HORTA, B. L.; LIU, C.-T.; BIELAK, L. F.; MOOK-KANAMORI, D. O.; MORRISON, A. C.; PEREIRA, A. C.; PSATY, B. M.; AMIN, N.; FOX, E. R.; KOOPERBERG, C.; WEN, W.; SIM, X.; BIERUT, L.; ROTTER, J. I.; BROWN, M. R.; KARDIA, S. L. R.; FRANCESCHINI, N.; RAO, D. C.; FORNAGE, M.; Lifelines Cohort Study; CHITRALA, K.; YANEK, L. R.; HARTWIG, F. P.; HORIMOTO, A. R. V. R.; LIU, Y.; MANNING, A. K.; NOORDAM, R.; SMITH, A. V.; HARRIS, S. E.; KüHNEL, B.; LYYTIKäINEN, L.-P.; NOLTE, I. M.; ARKING, D. E.; RAURAMAA, R.; MOST, P. J. van der; WANG, R.; WARE, E. B.; WEISS, S.; ARNETT, D. K.; BARAC, A.; BOERWINKLE, E.; BROECKEL, U.; CHAKRAVARTI, A.; CHEN, Y.-D. I.; CUPPLES, L. A.; LUIK, A. I.; DAVIGULUS, M. L.; FUENTES, L. de las; MUTSERT, R. de; VRIES, P. S. de; DELANEY, J. A. C.; ROUX, A. V. Diez; DöRR, M.; FAUL, J. D.; FRETTS, A. M.; GALLO, L. C.; MARTIN, L. W.; GRABE, H. J.; GU, C. C.; HARRIS, T. B.; HARTMAN, C. C. A.; HEIKKINEN, S.; IKRAM, M. A.; ISASI, C.; JOHNSON, W. C.; JONAS, J. B.; KAPLAN, R. C.; MEITINGER, T.; KOMULAINEN, P.; KRIEGER, J. E.; LEVY, D.; LIU, J.; LOHMAN, K.; MILANESCHI, Y.; O'CONNELL, J. R.; PALMAS, W. R.; PETERS, A.; PEYSER, P. A.; PULKKI-RåBACK, L.; RAFFEL, L. J.; ZHAO, W.; REINER, A. P.; RICE, K.; ROBINSON, J. G.; ROSENDAAL, F. R.; SCHMIDT, C. O.; SCHREINER, P. J.; SCHWETTMANN, L.; SHIKANY, J. M.; SHU, X.-O.; SIDNEY, S.; ZHU, X.; SIMS, M.; SMITH, J. A.; SOTOODEHNIA, N.; STRAUCH, K.; TAI, E. S.; TAYLOR, K. D.; UITTERLINDEN, A. G.; DUIJN, C. M. van; WALDENBERGER, M.; WEE, H.-L.; ZONDERMAN, A. B.; WEI, W.-B.; WILSON, G.; XUAN, D.; YAO, J.; ZENG, D.; BECKER, D. M.; DEARY, I. J.; GIEGER, C.; LAKKA, T. A.; LEHTIMäKI, T.; NORTH, K. E.; OLDEHINKEL, A. J.; BARTZ, T. M.; PENNINX, B. W. J. H.; SNIEDER, H.; WANG, Y.-X.; WEIR, D. R.; ZHENG, W.; EVANS, M. K.; GAUDERMAN, W. J.; GUDNASON, V.Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A and PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5 and CHODL). These findings underscore the importance of considering psychological and social factors in gene discovery for BP, especially in non-European populations. © 2020 The Author(s)
- Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci(2021) FUENTES, Lisa de las; SUNG, Yun Ju; NOORDAM, Raymond; WINKLER, Thomas; FEITOSA, Mary F.; SCHWANDER, Karen; BENTLEY, Amy R.; BROWN, Michael R.; GUO, Xiuqing; MANNING, Alisa; CHASMAN, Daniel I.; ASCHARD, Hugues; BARTZ, Traci M.; BIELAK, Lawrence F.; CAMPBELL, Archie; CHENG, Ching-Yu; DORAJOO, Rajkumar; HARTWIG, Fernando P.; HORIMOTO, A. R. V. R.; LI, Changwei; LI-GAO, Ruifang; LIU, Yongmei; MARTEN, Jonathan; MUSANI, Solomon K.; NTALLA, Ioanna; RANKINEN, Tuomo; RICHARD, Melissa; SIM, Xueling; SMITH, Albert V.; TAJUDDIN, Salman M.; TAYO, Bamidele O.; VOJINOVIC, Dina; WARREN, Helen R.; XUAN, Deng; ALVER, Maris; BOISSEL, Mathilde; CHAI, Jin-Fang; CHEN, Xu; CHRISTENSEN, Kaare; DIVERS, Jasmin; EVANGELOU, Evangelos; GAO, Chuan; GIROTTO, Giorgia; HARRIS, Sarah E.; HE, Meian; HSU, Fang-Chi; KUEHNEL, Brigitte; LAGUZZI, Federica; LI, Xiaoyin; LYYTIKAINEN, Leo-Pekka; NOLTE, Ilja M.; POVEDA, Alaitz; RAURAMAA, Rainer; RIAZ, Muhammad; RUEEDI, Rico; SHU, Xiao-ou; SNIEDER, Harold; SOFER, Tamar; TAKEUCHI, Fumihiko; VERWEIJ, Niek; WARE, Erin B.; WEISS, Stefan; YANEK, Lisa R.; AMIN, Najaf; ARKING, Dan E.; ARNETT, Donna K.; BERGMANN, Sven; BOERWINKLE, Eric; BRODY, Jennifer A.; BROECKEL, Ulrich; BRUMAT, Marco; BURKE, Gregory; CABRERA, Claudia P.; CANOUIL, Mickael; CHEE, Miao Li; CHEN, Yii-Der Ida; COCCA, Massimiliano; CONNELL, John; SILVA, H. Janaka de; VRIES, Paul S. de; EIRIKSDOTTIR, Gudny; FAUL, Jessica D.; FISHER, Virginia; FORRESTER, Terrence; FOX, Ervin F.; FRIEDLANDER, Yechiel; GAO, He; GIGANTE, Bruna; GIULIANINI, Franco; GU, Chi Charles; GU, Dongfeng; HARRIS, Tamara B.; HE, Jiang; HEIKKINEN, Sami; HENG, Chew-Kiat; HUNT, Steven; IKRAM, M. Arfan; IRVIN, Marguerite R.; KAHONEN, Mika; KAVOUSI, Maryam; KHOR, Chiea Chuen; KILPELAINEN, Tuomas O.; KOH, Woon-Puay; KOMULAINEN, Pirjo; KRAJA, Aldi T.; KRIEGER, J. E.; LANGEFELD, Carl D.; LI, Yize; LIANG, Jingjing; LIEWALD, David C. M.; LIU, Ching-Ti; LIU, Jianjun; LOHMAN, Kurt K.; MAGI, Reedik; MCKENZIE, Colin A.; MEITINGER, Thomas; METSPALU, Andres; MILANESCHI, Yuri; MILANI, Lili; MOOK-KANAMORI, Dennis O.; NALLS, Mike A.; NELSON, Christopher P.; NORRIS, Jill M.; O'CONNELL, Jeff; OGUNNIYI, Adesola; PADMANABHAN, Sandosh; PALMER, Nicholette D.; PEDERSEN, Nancy L.; PERLS, Thomas; PETERS, Annette; PETERSMANN, Astrid; PEYSER, Patricia A.; POLASEK, Ozren; PORTEOUS, David J.; RAFFEL, Leslie J.; RICE, Treva K.; ROTTER, Jerome I.; RUDAN, Igor; RUEDA-OCHOA, Oscar-Leonel; SABANAYAGAM, Charumathi; SALAKO, Babatunde L.; SCHREINER, Pamela J.; SHIKANY, James M.; SIDNEY, Stephen S.; SIMS, Mario; SITLANI, Colleen M.; SMITH, Jennifer A.; STARR, John M.; STRAUCH, Konstantin; SWERTZ, Morris A.; TEUMER, Alexander; THAM, Yih Chung; UITTERLINDEN, Andre G.; VAIDYA, Dhananjay; ENDE, M. Yldau van der; WALDENBERGER, Melanie; WANG, Lihua; WANG, Ya-Xing; WEI, Wen-Bin; WEIR, David R.; WEN, Wanqing; YAO, Jie; YU, Bing; YU, Caizheng; YUAN, Jian-Min; ZHAO, Wei; ZONDERMAN, Alan B.; BECKER, Diane M.; BOWDEN, Donald W.; DEARY, Ian J.; DOERR, Marcus; ESKO, Tonu; FREEDMAN, Barry I.; FROGUEL, Philippe; GASPARINI, Paolo; GIEGER, Christian; JONAS, Jost Bruno; KAMMERER, Candace M.; KATO, Norihiro; LAKKA, Timo A.; LEANDER, Karin; LEHTIMAKI, Terho; MAGNUSSON, Patrik K. E.; MARQUES-VIDAL, Pedro; PENNINX, Brenda W. J. H.; SAMANI, Nilesh J.; HARST, Pim van der; WAGENKNECHT, Lynne E.; WU, Tangchun; ZHENG, Wei; ZHU, Xiaofeng; BOUCHARD, Claude; COOPER, Richard S.; CORREA, Adolfo; EVANS, Michele K.; GUDNASON, Vilmundur; HAYWARD, Caroline; HORTA, Bernardo L.; KELLY, Tanika N.; KRITCHEVSKY, Stephen B.; LEVY, Daniel; PALMAS, Walter R.; PEREIRA, A. C.; PROVINCE, Michael M.; PSATY, Bruce M.; RIDKER, Paul M.; ROTIMI, Charles N.; TAI, E. Shyong; DAM, Rob M. van; DUIJN, Cornelia M. van; WONG, Tien Yin; RICE, Kenneth; GAUDERMAN, W. James; MORRISON, Alanna C.; NORTH, Kari E.; KARDIA, Sharon L. R.; CAULFIELD, Mark J.; ELLIOTT, Paul; MUNROE, Patricia B.; FRANKS, Paul W.; RAO, Dabeeru C.; FORNAGE, MyriamEducational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, ""Some College"" (yes/no) and ""Graduated College"" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 x 10(-8)). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.
- Evening preference correlates with regional brain volumes in the anterior occipital lobe(2021) EVANS, SL.; LEOCADIO-MIGUEL, M. A.; TAPOROSKI, T. P.; GOMEZ, L. M.; HORIMOTO, A. R. V. R.; ALKAN, E.; BEIJAMINI, F.; PEDRAZZOLI, M.; KNUTSON, K. L.; KRIEGER, J. E.; VALLADA, H. P.; STERR, A.; PEREIRA, A. C.; NEGRAO, A. B.; SCHANTZ, M. vonChronotype or diurnal preference is a questionnaire-based measure influenced both by circadian period and by the sleep homeostat. In order to further characterize the biological determinants of these measures, we used a hypothesis-free approach to investigate the association between the score of the morningness-eveningness questionnaire (MEQ) and the Munich chronotype questionnaire (MCTQ), as continuous variables, and volumetric measures of brain regions acquired by magnetic resonance imaging (MRI). Data were collected from the Baependi Heart Study cohort, based in a rural town in South-Eastern Brazil. MEQ and anatomical 1.5-T MRI scan data were available from 410 individuals, and MCTQ scores were available from a subset of 198 of them. The average MEQ (62.2 +/- 10.6) and MCTQ (average MSFsc 201 +/- 85 min) scores were suggestive of a previously reported strong general tendency toward morningness in this community. Setting the significance threshold at P > .002 to account for multiple comparisons, we observed a significant association between lower MEQ score (eveningness) and greater volume of the left anterior occipital sulcus (beta = -0.163, p = .001) of the occipital lobe. No significant associations were observed for MCTQ. This may reflect the smaller dataset for MCTQ, and/or the fact that MEQ, which asks questions about preferred timings, is more trait-like than the MCTQ, which asks questions about actual timings. The association between MEQ and a brain region dedicated to visual information processing is suggestive of the increasingly recognized fluidity in the interaction between visual and nonvisual photoreception and the circadian system, and the possibility that chronotype includes an element of masking.