JOAO DE MAGALHAES AVANCINI FERREIRA ALVES
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
33 resultados
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- Generalized Lenticular Atrophoderma of Pasini and Pierini(2015) AVANCINI, Joao; VALENTE, Neusa Yuriko S.; ROMITI, RicardoWe present a 16-year-old boy with multiple, well-circumscribed, atrophic, light-brown patches on his neck, chest, and back. The authors believe that it represents an unusual presentation of atrophoderma of Pasini and Pierini and suggest the designation generalized lenticular APP.
- Dermatoscopy: an auxiliary resource for the diagnosis of poroid neoplasms(2018) SARAIVA, Maria Isabel Ramos; FERREIRA, Paula Silva; AVANCINI, Joao; VALENTE, Neusa Yuriko SakaiPoroid neoplasms are benign epithelial proliferations with eccrine sweat gland differentiation. They are a challenging diagnosis because of the clinical heterogeneity, being able to mimic several malignant neoplasms. They are classified into dassic poroma, hidroacanthoma simplex, dermal duct tumor and poroid hidradenoma. Association of histological subtypes occurs in more than 25% of cases. We report a case of a combined poroid neoplasia of classical poroma and poroid hidradenoma, reviewing its dermatoscopic features.
bookPart Hanseníase(2016) AVANCINI, João; TRINDADE, Maria Angela Bianconcini- Trichoscopic findings of eyebrow alopecia in patients with multibacillary leprosy(2019) DOCHE, Isabella; TOSTI, Antonella; NETO, Cyro F.; TRINDADE, Maria Angela B.; RIVITTI-MACHADO, Maria Cecilia M.; AVANCINI, Joao
conferenceObject Necrotisans erythema nodosum leprosum with systemic manifestations(2018) ISHIY, Patricia; TRINDADE, Maria Angela; AVANCINI, Joao; PAZZINI, Renato; JORGE, Lecticia; SOTTO, Mirian- Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients(2015) AVANCINI, J.; MARAGNO, L.; SANTI, C. G.; CRIADO, P. R.BackgroundDrug reaction with eosinophilia and systemic symptoms (DRESS) [also called drug-induced hypersensitivity syndrome (DIHS)] includes severe reactions to drugs that need to be promptly recognized by physicians. AimTo explore heterogeneity in the clinical presentation of DRESS/DIHS at a large academic hospital in Latin America, using the criteria defined by the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) scoring system. MethodsA retrospective medical record review of 60 patients with diagnostic suspicion of DRESS/DIHS admitted to our hospital between July 2008 and April 2012 was performed, including demographic data, clinical features, laboratory findings and treatment. ResultsOf the 60 patients, 27 fulfilled the criteria for DRESS/DIHS. Maculopapular exanthema (85.1%), fever (96.2%) and hepatic involvement (85.1%) were the most common features. Anticonvulsants were the most common causal drugs (77.7%); Phenytoin was the most common individual drug (44.4%), followed by carbamazepine (29.6%). All patients were treated initially with prednisone 1mg/kg/day. Mortality rate was 4%. ConclusionThe major findings of this study (to our knowledge the largest collection of data on DRESS/DIHS in Latin America) include a positive statistical association between presence of atypical lymphocytes and higher levels of alanine aminotransferase (P<0.001) and reinforce the importance of anticonvulsants in the pathogenesis of this severe reaction.
article 1 Citação(ões) na Scopus Severe adverse reactions to multidrug therapy for leprosy, registered in tertiary services between 2012 and 2017 in Brazil(2018) PANTE, Cristina Castro; COELHO, Silvio Caetano; CARELLI, Luzia; AVANCINI, Joao; TRINDADE, Maria Angela BianconciniObjectives: This work aims to determinate the main severe adverse reactions to multidrug therapy (MDT), as well as the characteristics of the patients who had them and the period when they were more prevalent. Results: Of the 158 patients undergoing treatment for leprosy in the period 2012-2017, 22 (13.9%) were using substitutive treatment for leprosy and presented criteria to enter this study. Adverse reactions were more frequent in women (59.1%), above 45 years age and during second month of treatment. Dapsone was the most frequently implied drug (86.4%), and hemolytic anemia was the main reaction (72.7%). Conclusion: Severe adverse reaction to dapsone is common in MDT, mainly due to hemolytic anemia.- Angiosarcoma in HIV-negative patients is not associated with HHV-8(2016) AVANCINI, Joao; CHERUBIM, Andre Pires Zanata; OLIVEIRA, Cristina Mendes de; VALENTE, Neusa Yuriko Sakai; FESTA NETO, Cyro; SANCHES, Jose Antonio; PAZZINI, Renato; SUMITA, Laura Masami; PANNUTI, Claudio SergioBACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE: To investigate the relationship between the presence of HHV-8 and angiosarcoma. METHODS: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls. RESULTS: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was. CONCLUSION: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.
bookPart Reações Medicamentosas(2016) SANTI, Claudia Giuli; DIAS, Natasha Favoretto; AVANCINI, JoãobookPart Hanseníase(2022) ALVES, João de Magalhães Avancini Ferreira; TRINDADE, Maria Ângela Bianconcini