BRAIAN LUCAS AGUIAR SOUSA
Projetos de Pesquisa
Unidades Organizacionais
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/42 - Laboratório de Hormônios e Genética Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/42 - Laboratório de Hormônios e Genética Molecular, Hospital das Clínicas, Faculdade de Medicina
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bookPart Cricotireoidostomia(2017) SOUSA, Braian Lucas Aguiar; OGATA, Fiama Kuroda; OKUMA, Jéssica Kazumi; BRESCIA, Marília D'Elboux Guimarães; TIERNO, Paulo Fernando Guimarães Marzocchi; HOJAIJ, Flávio CarneirobookPart Epidemiologia, transmissão e fatores de risco da COVID-19(2021) BRENTANI, Alexandra Valeria Maria; FERRARO, Alexandre Archanjo; SOUSA, Braian Lucas Aguiar- Non-communicable diseases, sociodemographic vulnerability and the risk of mortality in hospitalised children and adolescents with COVID-19 in Brazil: a cross-sectional observational study(2021) SOUSA, Braian Lucas Aguiar; BRENTANI, Alexandra; RIBEIRO, Cecilia Claudia Costa; DOLHNIKOFF, Marisa; GRISI, Sandra Josefina Ferraz Ellero; FERRER, Ana Paula Scoleze; FERRARO, Alexandre ArchanjoObjectives To analyse how previous comorbidities, ethnicity, regionality and socioeconomic development are associated with COVID-19 mortality in hospitalised children and adolescents. Design Cross-sectional observational study using publicly available data from the Brazilian Ministry of Health. Setting Nationwide. Participants 5857 patients younger than 20 years old, all of them hospitalised with laboratory-confirmed COVID-19, from 1 January 2020 to 7 December 2020. Main outcome measure We used multilevel mixed-effects generalised linear models to study in-hospital mortality, stratifying the analysis by age, region of the country, presence of non-communicable diseases, ethnicity and socioeconomic development. Results Individually, most of the included comorbidities were risk factors for mortality. Notably, asthma was a protective factor (OR 0.4, 95% CI 0.24 to 0.67). Having more than one comorbidity increased almost tenfold the odds of death (OR 9.67, 95% CI 6.89 to 13.57). Compared with white children, Indigenous, Pardo (mixed) and East Asian had significantly higher odds of mortality (OR 5.83, 95% CI 2.43 to 14.02; OR 1.93, 95% CI 1.48 to 2.51; OR 2.98, 95% CI 1.02 to 8.71, respectively). We also found a regional influence (higher mortality in the North-OR 3.4, 95% CI 2.48 to 4.65) and a socioeconomic association (lower mortality among children from more socioeconomically developed municipalities-OR 0.26, 95% CI 0.17 to 0.38) Conclusions Besides the association with comorbidities, we found ethnic, regional and socioeconomic factors shaping the mortality of children hospitalised with COVID-19 in Brazil. Our findings identify risk groups among children that should be prioritised for public health measures, such as vaccination.
- Differences among Severe Cases of Sars-CoV-2, Influenza, and Other Respiratory Viral Infections in Pediatric Patients: Symptoms, Outcomes and Preexisting Comorbidities(2020) SOUSA, Braian L. A.; SAMPAIO-CARNEIRO, Magda; CARVALHO, Werther B. de; SILVA, Clovis A.; FERRARO, Alexandre A.OBJECTIVES: Previous studies focusing on pediatric patients hospitalized with severe coronavirus disease 2019 (COVID-19) have been limited to small case series. We aimed to evaluate the characteristics of a large population of pediatric patients with severe COVID-19 and compare them with patients with severe cases of influenza and other respiratory viruses (ORV). METHODS: We performed a cross-sectional study of Brazilian data from the National Epidemiological Surveillance Information System, gathered from January 1st to July 14th, 2020. The sample included 4,784 patients (2,570 with confirmed COVID-19, 659 with influenza, 1,555 with ORV). Outcome measures included clinical features, preexisting comorbidities, pediatric intensive care unit admissions, need for ventilatory support, and death. RESULTS: Compared with the influenza and ORV groups, the COVID-19 group had a higher proportion of newborns and adolescents, as well as lower frequencies of fever, cough, dyspnea, respiratory distress, and desaturation. Although use of invasive ventilatory support was similar among groups, death rate was highest for COVID-19 (15.2% vs. 4.5% vs. 3.2%, p <0.001), with death risk more than three times the other groups (adjusted OR=3.7 [95% CI 2.5-5.6]). The presence of two or more comorbidities further increased this risk (OR=4.8 [95% CI 3.5-6.6]). Preexisting comorbidities were reported in 986 patients with severe COVID-19 (38%). Mortality rate among COVID-19 patients was significantly higher for almost all comorbidities reported. CONCLUSION: Severe COVID-19 had a higher mortality rate than other viral respiratory illnesses, despite the lower frequency of fever, cough, dyspnea, respiratory distress, and desaturation. Death risk was strongly associated with preexisting comorbidities.
- The double-edged sword: COVID-19 pandemic-related delay in immune maturation in young children(2023) AGUIAR, Braian Lucas; CARNEIRO-SAMPAIO, Magda Maria Sales
- Mutation analysis of NANOS3 in Brazilian women with primary ovarian failure(2016) SOUSA, Braian Lucas A.; NISHI, Mirian Yumie; SANTOS, Mariza Gerdulo; BRITO, Vinicius Nahime; DOMENICE, Sorahia; MENDONCA, Berenice B.OBJECTIVES: Primary ovarian failure is a rare disorder, and approximately 90% of cases are of unknown etiology. The aim of this study was to search for mutations in NANOS3, a gene that was recently related to the etiology of primary ovarian failure, in a group of Brazilian women. METHODS: We screened for NANOS3 DNA variants in 30 consecutive women who were previously diagnosed with primary ovarian failure, of unknown etiology and compared the results with those from 185 women with normal fertility. The NANOS3 gene was amplified by polymerase chain reaction using pairs of specific primers and then sequenced. The resulting sequences were compared with control sequences available in the National Center for Biotechnology and Information database. RESULTS: No mutations in NANOS3 were found in primary ovarian failure patients, but four previously described polymorphisms were identified at a similar frequency in the control and primary ovarian failure groups. CONCLUSIONS: Mutations in NANOS3 were not associated with primary ovarian failure in the present cohort.
bookPart Cateter venoso central em veia jugular interna(2017) OGATA, Fiama Kuroda; OKUMA, Jéssica Kazumi; SOUSA, Braian Lucas Aguiar; BRESCIA, Marília D'Elboux Guimarães; TIERNO, Paulo Fernando Guimarães Marzocchi; HOJAIJ, Flávio Carneiro- An update on the epidemiology of pediatric COVID-19 in Brazil(2022) SOUSA, Braian Lucas Aguiar; SILVA, Clovis Artur; FERRARO, Alexandre Archanjo
bookPart Epidemiologia, transmissão e fatores de risco da COVID-19(2023) BRENTANI, Alexandra Valeria Maria; FERRARO, Alexandre Archanjo; FERRER, Ana Paula Scoleze; SOUSA, Braian Lucas Aguiar