PASESA PASCUALA QUISPE TORREZ
Projetos de Pesquisa
Unidades Organizacionais
LIM/48 - Laboratório de Imunologia, Hospital das Clínicas, Faculdade de Medicina
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
bookPart Acidentes por animais peçonhentos(2017) FRANçA, Francisco Oscar de Siqueira; DUARTE, Marcelo Ribeiro; TORREZ, Pasesa Pascuala Quispe; HADDAD JUNIOR, Vidal- Acute cerebellar dysfunction with neuromuscular manifestations after scorpionism presumably caused by Tityus obscurus in Santarem, Para/Brazil(2015) TORREZ, Pasesa P. Q.; QUIROGA, Mariana M. M.; ABATI, Paulo A. M.; MASCHERETTI, Melissa; COSTA, Walter Silva; CAMPOS, Luciana P.; FRANCA, Francisco O. S.Scorpionism is a public health problem in many tropical countries, especially in North Africa, South India, Latin America and the Middle East. In Brazil, patients with severe scorpion envenoming have mainly cardiovascular events, including acute heart failure, acute respiratory distress syndrome and shock, death is rare. We described 58 accidents presumably caused by Tityus obscurus in Brazilian Amazonia. Patients reported a sensation of ""electric shocks"" which could last hours. The vast majority of patients presented a clinical picture compatible with acute cerebellar dysfunction, beginning minutes and lasting up to 2 days after the accident. They presented cerebellar ataxia, dysdiadochokinesia, dysmetry, dysarthria, dyslalia, nausea and vomiting. Besides, some patients presented myoclonus and fasciculation which can also be attributed to cerebellar dysfunction or maybe the result of direct action on skeletal muscle. Two patients had evidence of intense rhabdomyolysis and acute kidney injury. The clinical picture in this scorpion envenoming is mainly characterized by an acute dysfunction of cerebellar activities and abnormal neuromuscular manifestations and in some cases muscle injury which are not described in any other region of the world. This work presents clinical, epidemiologic, laboratory and treatment aspects of this unmatched scorpion envenoming in the state of Para, northern Brazil.
bookPart Acidentes por animais peçonhentos(2015) FRANçA, Francisco Oscar de Siqueira; DUARTE, Marcelo Ribeiro; TORREZ, Pasesa Pascuala Quispe; HADDAD JUNIOR, Vidal- Transmission of Human Herpesvirus Type 8 Infection Within Families in American Indigenous Populations From the Brazilian Amazon(2012) BORGES, Jaila D.; SOUZA, Vanda A. U. F.; GIAMBARTOLOMEI, Claudia; DUDBRIDGE, Frank; FREIRE, Wilton S.; GREGORIO, Shinai Arriel; TORREZ, Pasesa Pascuala Quispe; QUIROGA, Mariana; MAYAUD, Philippe; PANNUTI, Claudio S.; NASCIMENTO, Maria ClaudiaBackground. The intrafamilial dynamics of endemic infection with human herpesvirus type 8 (HHV-8) in Amerindian populations is unknown. Methods. Serum samples were obtained from 517 Amerindians and tested for HHV-8 anti-latent nuclear antigen (anti-LANA) and antilytic antibodies by immunofluorescence assays. Logistic regression and mixed logistic models were used to estimate the odds of being HHV-8 seropositive among intrafamilial pairs. Results. HHV-8 seroprevalence by either assay was 75.4% (95% confidence interval [CI]: 71.5%-79.1%), and it was age-dependent (P-trend<.001). Familial dependence in HHV-8 seroprevalence by either assay was found between mother-offspring (odds ratio [OR], 5.44; 95% CI: 1.62-18.28) and siblings aged >= 10 years (OR 4.42, 95% CI: 1.70-11.45) or siblings in close age range (<5 years difference) (OR 3.37, 95% CI: 1.21-9.40), or in families with large (>4) number of siblings (OR, 3.20, 95% CI: 1.33-7.67). In separate analyses by serological assay, there was strong dependence in mother-offspring (OR 8.94, 95% CI: 2.94-27.23) and sibling pairs aged >= 10 years (OR, 11.91, 95% CI: 2.23-63.64) measured by LANA but not lytic antibodies. Conclusions. This pattern of familial dependence suggests that, in this endemic population, HHV-8 transmission mainly occurs from mother to offspring and between close siblings during early childhood, probably via saliva. The mother to offspring dependence was derived chiefly from anti-LANA antibodies.
- Injuries caused by freshwater stingrays in the Tapajos River Basin: a clinical and sociodemographic study(2017) ABATI, Paulo Afonso Martins; TORREZ, Pasesa Pascuala Quispe; FRANCA, Francisco Oscar de Siqueira; TOZZI, Fabio Lambertini; GUERREIRO, Flavio Mileo Bacelar; SANTOS, Suellen Aline Torres dos; OLIVEIRA, Sheyla Mara Silva de; HADDAD JUNIOR, VidalFreshwater stingray envenomations are an important cause of morbidity in riverine populations living in various regions of Brazil. The sequelae include temporary or permanent disability. This study aimed to identify sociodemographic, clinical, and therapeutic aspects related to stingray injuries in such populations. Methods: This cross-sectional study was conducted in the Extractive Reserve of Tapajos-Arapiuns, located in the municipalities of Santarem and Aveiro (Para State). A convenience sample comprising 300 local adults was used to obtain data by means of a questionnaire/interview. Results: Overall, 19 (6.3%) participants reported having sustained a stingray injury in the 12 months prior to the study. All 19 were injured either while fishing (n=13 [68.4%]) or engaging in other riverine activities. Most injuries [n=14 (73.7%)] occurred from September through November, and most injured respondents [n=15 (78.9%)] reported seeing stingrays at beaches. Severe pain and the appearance of ulcers in the later stages of envenomation were described by 18 (94.7%) and 12 (63.2%) participants, respectively. Conclusions: Freshwater stingray injuries, which should be considered occupational injuries, are common in the study area, especially in places like beaches or in the lakes that form during the dry season, when stingrays are routinely observed. A significant proportion of respondents was unaware of the correct first aid measures and had insufficient resources to treat the complications of these injuries in the locality where they reside. Interactive activities involving local residents - such as lectures and the distribution of simple pamphlets providing information about stingray injuries - are needed.
- Tetanus after envenomations caused by freshwater stingrays(2015) TORREZ, Pasesa P. Q.; QUIROGA, Mariana M.; SAID, Renato; ABATI, Paulo A. M.; FRANCA, Francisco O. S.Injuries caused by freshwater stingray are common in several regions of South America, although they are underreported. The riverside inhabitants are the main victims in the Amazonian and Midwest regions of South America. The fishermen are injured mainly in the new focus of colonization of the rivers by freshwater stingrays. With the increasing population in these regions, where freshwater stingrays are found, there has been a significant increase in injuries within the general population. The highest increase occurred among tourists from other regions, where these animals are not known, when visiting these areas. The envenomations from the stingray causes prolonged and intense pain, both local and regionally. Generally these are associated with other local inflammatory manifestations, such as swelling and erythema. The injury often progresses to necrosis and it is considered potentially tetanogenic. A secondary infection is also a frequent local complication and most frequently is caused by Aeromonas species, usually Aeromonas hydrophila. Herein we report the first 2 cases of tetanus after freshwater stingray injuries: a 51-year-old men who had tetanus and recovered without sequel and the second a 67-year-old men who had severe tetanus and a deep, necrotizing soft-tissue infection with sepsis, septic shock and evolution to death.
- Forest pit viper (Bothriopsis bilineata bilineata) bite in the Brazilian Amazon with acute kidney injury and persistent thrombocytopenia(2014) TORREZ, P. P. Q.; SAID, R.; QUIROGA, M. M. M.; DUARTE, M. R.; FRANCA, F. O. S.There are six species of Bothriopsis in Latin America, accidents caused by this genus are unusually reported. A 37-year-old man admitted thirty hours after a snakebite to the emergency department of Santarem City Hospital (SCH), northern Brazil. The patient presented local erythema, edema, increased local temperature and blister with serous fluid in the right arm. He developed acute kidney injury (AKI) and prolonged thrombocytopenia. The blood was incoagulable and he was treated with anti-bothropic antivenom and antibiotics. The patient had complete regression of all clinical and laboratory manifestations at varying intervals. The platelet counts returned to normal almost 2 weeks after administration of specific antivenom. The present report is the first accident caused by a snake of forest pit viper (Bothriopsis bilineata) in the Brazilian Amazon forest.
bookPart Acidentes por Animais Peçonhentos(2016) FRANçA, Francisco Oscar de Siqueira; RECKZIEGEL, Guilherme Carneiro; MEDEIROS, Carlos Roberto de; MáLAQUE, Ceila Maria Sant'Ana; DUARTE, Marcelo Ribeiro; TAVASSI, Ana Marisa Chudzinski; ZANNIN, Marlene; MORAES, Roberto Henrique Pinto; BENVENUTI, Luiz Alberto; MARQUES, Marisa Mazzoncini de Azevedo; CUPO, Palmira; TORREZ, Pasesa Pascuala Quispe; HERING, Sylvia Evelyn; HADDAD JUNIOR, Vidal; CARDOSO, João Luiz CostabookPart Acidentes provocados por animais peçonhentos(2013) WEN, Fan Hui; MáLAQUE, Ceila Maria Sant'Anna; MEDEIROS, Carlos Roberto; DUARTE, Marcelo Ribeiro; TORREZ, Pasesa Pascuala Quispe; NOVAES, Christina Terra Gallafrio; FRANçA, Francisco Oscar de Siqueira- First report of hepatic hematoma after presumed Bothrops envenomation(2015) CUNHA, Fernando Cristina; HEERDT, Maike; TORREZ, Pasesa Pascuala Quispe; FRANCA, Francisco Oscar de Siqueira; MOLIN, Graziela Zibetti Dal; BATTISTI, Rubia; ZANNIN, MarleneIn Latin America, Bothrops envenomation is responsible for the majority of accidents caused by venomous snakes. Patients usually present local edema, bleeding and coagulopathy. Visceral hemorrhage is extremely rare and considered a challenge for diagnosis and management. We report the first case of hepatic hematoma owing to the bothropic envenomation in a 66-year-old man who was bitten in the left leg. He presented local edema, coagulopathy, and acute kidney injury. Radiological findings suggested hepatic hematoma, with a volume of almost 3 liters. The hepatic hematoma was gradually absorbed without the need for surgical intervention with complete resolution in 8 months.