PAULO ROSSI MENEZES
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Medicina Preventiva, Faculdade de Medicina - Docente
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
16 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 16
- Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations(2013) TAMASHIRO-DURAN, Jaqueline Hatsuko; SQUARZONI, Paula; DURAN, Fabio Luis de Souza; CURIATI, Pedro Kallas; VALLADA, Homero Pinto; BUCHPIGUEL, Carlos Alberto; LOTUFO, Paulo Andrade; WAJNGARTEN, Mauricio; MENEZES, Paulo Rossi; SCAZUFCA, Marcia; ALVES, Tania Correa de Toledo Ferraz; BUSATTO, Geraldo FilhoCardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented carriers of the apolipoprotein epsilon 4 (APOE epsilon 4) allele, the major genetic risk factor for AD. However, functional neuroimaging studies investigating the impact of CVRF on cerebral metabolism have been scarce to date. The present FDG-PET study investigated 59 cognitively preserved elderlies divided into three groups according to their cardiovascular risk based on the Framingham 10-year risk Coronary Heart Disease Risk Profile (low-, medium-, and high-risk) to examine whether different levels of CVRF would be associated with reduced CMRgl, involving the same brain regions affected in early stages of AD. Functional imaging data were corrected for partial volume effects to avoid confounding effects due to regional brain atrophy, and all analyses included the presence of the APOE epsilon 4 allele as a confounding covariate. Significant cerebral metabolism reductions were detected in the high-risk group when compared to the low-risk group in the left precuneus and posterior cingulate gyrus. This suggests that findings of brain hypometabolism similar to those seen in subjects with AD can be detected in association with the severity of cardiovascular risk in cognitively preserved individuals. Thus, a greater knowledge about how such factors influence brain functioning in healthy subjects over time may provide important insigths for the future development of strategies aimed at delaying or preventing the vascular-related triggering of pathologic brain changes in the AD.
- The relationship between perinatal psychiatric disorders and contraception use among postpartum women(2013) FAISAL-CURY, Alexandre; MENEZES, Paulo Rossi; HUANG, HsiangBackground: The relationship between perinatal psychiatric disorders and the use of effective contraceptive methods among postpartum women served by primary care clinics has not been established. Study Design: This was a prospective cohort study with 831 pregnant women recruited from 10 primary care clinics of the public sector in Sao Paulo followed up to 18 months after delivery. Results: Among 701 postpartum women, 644 women (91.8%) had resumed sexual activity. Two hundred fifty-three women (39.2%) were classified as using a less effective contraception method (LECM). The presence of perinatal psychiatric disorder (in pregnancy and/or postpartum) was not associated with LECM. Resumption of sexual life 3 months or beyond after delivery was associated with LECM (odds ratio=1.28, 95% confidence interval: 1.02-1.56). Discussion: Although the use of an LECM after delivery is common, contraception choice is not associated with perinatal depressive/anxiety symptoms. However, women who delay the resumption of sexual activity after delivery should be counseled on the use of available contraceptive methods.
- Intimate partner violence among undergraduate students of two universities of the state of Sao Paulo, Brazil(2013) FLAKE, Tania Aldrighi; BARROS, Claudia; SCHRAIBER, Lilia B.; MENEZES, Paulo RossiINTRODUCTION: The prevalence of violence in intimate relationships, suffered or perpetrated, was estimated among undergraduate students, be it physical, psychological and sexual, describing the overlap between them. This is an original study and there is scarce literature on this matter in Brazil. Men and women were investigated and some issues on gender violence were discussed. METHODS: The study is part of the multicenter survey ""International Study of Violence in Dating - IDVS"" conducted in 2002 - 2003, using its standardized instrument. A total of 362 students, from two universities in the state of São Paulo, one public and one private, answered the self-reported questionnaire, being 37% male and 63% female, mean age of 20 years old. Suffered and perpetrated intimate partner violence during life was examined. RESULTS: Among all interviewees, 75.9% suffered and 76.4% perpetrated some kind of violence throughout life. Psychological violence was the most prevalent type, followed by sexual violence, both suffered and perpetrated. The great superposition between suffered and perpetrated violence (83.9%) reflects the reciprocity of aggression, with no observed difference between men and women. The results of this study are consistent with previous literature on dating violence, which shows high prevalence of suffered and perpetrated violence, besides reciprocity for both men and women. CONCLUSIONS: Intervention actions at this stage of intimate relationships may potentially impact on subsequent marital partnership situations.
- Very low levels of education and cognitive reserve A clinicopathologic study(2013) FARFEL, Jose Marcelo; NITRINI, Ricardo; SUEMOTO, Claudia Kimie; GRINBERG, Lea Tenenholz; FERRETTI, Renata Eloah Lucena; LEITE, Renata Elaine Paraizo; TAMPELLINI, Edilaine; LIMA, Luzia; FARIAS, Daniela Souza; NEVES, Ricardo Caires; RODRIGUEZ, Roberta Diehl; MENEZES, Paulo Rossi; FREGNI, Felipe; BENNETT, David A.; PASQUALUCCI, Carlos Augusto; JACOB FILHO, WilsonObjective: We conducted a clinicopathologic study in a large population with very low levels of education to determine whether very few years of education could contribute to cognitive reserve and modify the relation of neuropathologic indices to dementia. Methods: In this cross-sectional study, we included 675 individuals 50 years of age or older from the Brazilian Aging Brain Study Group. Cognitive abilities were evaluated through a structured interview with an informant at the time of autopsy, including the Clinical Dementia Rating (CDR) scale. Neuropathologic examinations were performed using immunohistochemistry and following internationally accepted criteria. Multivariate linear regression models were conducted to determine whether the association between cognitive abilities (measured by CDR sum of boxes) and years of education was independent of sociodemographic variables and neuropathologic indices, including neuritic plaques, neurofibrillary tangles, lacunar infarctions, small-vessel disease, and Lewy bodies. In addition, interaction models were used to examine whether education modified the relation between neuropathologic indices and cognition. Results: Mean education was 3.9 +/- 3.5 years. Formal education was associated with a lower CDR sum of boxes (beta = -0.197; 95% confidence interval -0.343, -0.052; p = 0.008), after adjustment for sociodemographic variables and neuropathologic indices. Furthermore, education modified the relationship of lacunar infarcts with cognitive abilities (p = 0.04). Conclusions: Even a few years of formal education contributes to cognitive reserve.
conferenceObject Increasing the likelihood of identification and treatment of depression during pregnancy as a strategy to prevent mental health problems during childhood and adolescence(2013) SCAZUFCA, Marcia; CURI, Alexandre Faisal; MOGADOURO, Monica; RAMIREZ, Ariete; FENERICH, Silvia; ALMEIDA, Simone; QUAYLE, Julieta; DANGELO, Luiz Antonio; SANTOS, Renata Nunes; ARAYA, Ricardo; MENEZES, Paulo Rossi- Temporal Relationship Between Intimate Partner Violence and Postpartum Depression in a Sample of Low Income Women(2013) FAISAL-CURY, Alexandre; MENEZES, Paulo Rossi; D'OLIVEIRA, Ana Flavia Pires Lucas; SCHRAIBER, Lilia Blima; LOPES, Claudia S.To estimate whether there is a temporal association between Postpartum Depression (PPD) and intimate partner violence (IPV), and to assess the potential role of social support on this relationship. A cross-sectional study was conducted between January 2006 and March 2007 with 701 low income women who received prenatal and postpartum care in primary health care units of the public sector in So Paulo, Brazil. The Self-Report Questionnaire (SRQ-20) was used to assess the presence of PPD. Structured standardized questionnaires were used to assess IPV and social support. The prevalence of PPD was estimated with a 95 % confidence interval. Crude and adjusted prevalence ratios were calculated using Poisson regression to examine the association between PPD and exposure variables. Values of p < 0.05 were considered statistically significant. The prevalence of PPD was 27.9 % (95 %CI 24.6:31.2). The prevalence of psychological IPV was 38.6 %, physical IPV 23.4 %, and sexual IPV 7.1 %. The multivariate analysis showed that PPD was strongly associated with current psychological and physical/sexual violence, after controlling for confounding factors, and less so with past (prenatal or lifetime) IPV. Presence of social support was an independent protective factor for PPD. Identifying and addressing intimate partner violence, including psychological violence, in the postpartum period should be considered as part of a comprehensive approach to caring for new mothers.
- The worldwide prevalence of insufficient physical activity in adolescents; a systematic review(2013) MORAES, Augusto Cesar Ferreira de; GUERRA, Paulo Henrique; MENEZES, Paulo RossiObjective: To perform a systematic review of cross-sectional studies on the prevalence of insufficient physical activity (IPA) based on a WHO-defined cutoff point (<60 min/d of moderate and vigorous physical activity). Methods: The search was carried out using online databases (BioMed Central, CINAHL, EMBASE, ERIC, PsycInfo, PubMed MEDLINE, SCOPUS, SPORT-Discus), and included articles published from the beginning of the databases until February18th, 2012, as well as references cited by the retrieved articles and information provided by the authors. Only original articles using questionnaires in the diagnosis were considered. Results: Of 2,384 papers initially retrieved, fifteen studies met the inclusion criteria, of which seven were conducted in Brazil. The prevalence of IPA varied from 18.7% to 90.6%, with a median of 79.7%. In all surveys, the prevalence was higher among girls than boys and the developing countries have higher prevalence. Conclusions: We concluded that the prevalence of IPA is high among adolescents and that the definition adopted in this study is rarely used in the literature. These results suggesting that is necessary the development of interventions for increasing physical activity levels among adolescents.
- Cannabis use, cognition and brain structure in first-episode psychosis (vol 147, pg 209, 2013)(2013) CUNHA, Paulo Jannuzzi; ROSA, Pedro Gomes P.; AYRES, Adriana de Mello; DURAN, Fabio L. S.; SANTOS, Luciana C.; SCAZUFCA, Marcia; MENEZES, Paulo R.; SANTOS, Bernardo dos; MURRAY, Robin M.; CRIPPA, Jose Alexandre S.; BUSATTO, Geraldo F.; SCHAUFELBERGER, Maristela S.
- Two-Year Anemia Incidence and Causes in Older Individuals with Near-Abnormal Baseline Hemoglobin Levels: The SAo Paulo Ageing and Health Study(2013) SANTOS, Itamar S.; SCAZUFCA, Marcia; LOTUFO, Paulo A.; MENEZES, Paulo R.; BENSENOR, Isabela M.
- Serum phosphate and hip bone mineral density as additional factors for high vascular calcification scores in a community-dwelling: The Sao Paulo Ageing & Health Study (SPAH)(2013) FIGUEIREDO, Camille P.; RAJAMANNAN, Nalini M.; LOPES, Jaqueline B.; CAPARBO, Valeria F.; TAKAYAMA, Liliam; KUROISHI, Marcia E.; OLIVEIRA, Ilka S.; MENEZES, Paulo R.; SCAZUFCA, Marcia; BONFA, Eloisa; PEREIRA, Rosa M. R.Objective: To analyze the association between abdominal aortic calcification scores (AACS) and bone metabolism parameters in a well-characterized general population of older adults. Background: Several studies suggest a link between bone mineral metabolism disorders and vascular calcification; although only few of them analyze bone mineral density(BMD), laboratory bone markers and cardiovascular parameters at the same time and none were done in a miscegenated population. Methods: This cross-sectional study included 815 subjects >= 65 years old. The risk factors for osteoporosis and cardiovascular disease as well as a wide array of demographic and lifestyle characteristics were collected using a standardized questionnaire. BMD was measured by DXA. Kauppila's method was used to quantify the MC score (AACS) by spine X-rays. Laboratory analyses were also performed. Results: MC was observed in 63.2% of subjects with a median AACS of 2 (IQR: 0-7). AACS were categorized in quartiles and the highest quartile of AACS (>7) were compared with the three lower quartiles of AACS (<= 7). Logistic regression analysis was performed using parameters with statistical significance in the univariate analysis. The best logistic regression model revealed that AACS>7 was negatively associated with femoral neck BMD and positively associated with phosphorus, adjusted by age, current smoking, LDL, and arterial hypertension in the elderly community-dwelling population. Conclusions: We identified that higher serum phosphate levels and lower hip BMD are independent bone variables that are associated with elevated vascular calcification scores, supporting the search for effective prevention and treatment strategies that may simultaneously reduce these modifiable risk factors in older subjects.