JULIA THIEMI TAKIUTI
Índice h a partir de 2011
8
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
17 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 17
- Non-paraneoplastic related retinopathy: clinical challenges and review(2019) TAKIUTI, Julia T.; TAKAHASHI, Vitor K. L.; XU, Christine L.; JAUREGUI, Ruben; TSANG, Stephen H.Autoimmune retinopathy (AIR) is a rare inflammatory condition characterized by progressive visual loss, abnormalities in visual fields and electroretinographic exams, along with presence of circulating anti-retinal antibodies. There are two main forms of AIR: paraneoplastic AIR (pAIR) and presumed non-paraneoplastic AIR (npAIR). NpAIR is considered a diagnosis of exclusion, since it is typically made after other causes of retinopathy have been investigated and the absence of malignancy is confirmed. Work-up of a npAIR case is challenging since there are no standartizaded protocols for diagnosis and treatment. The treatment regimen may vary from case to case, and it can be best guided by a set of parameters including electrophysiological responses, visual outcomes, and presence of anti-retinal antibodies. The purpose of this review is to summarize the principal clinical features, investigation, and management of npAIR.
conferenceObject Association between visual function and quality of life in patients with Vogt-Koyanagi-Harada disease(2018) TAKIUTI, J. H. Yamamoto; MISSAKA, R. F.; SOUTO, F. M.; MARCHIORI, B. M.; CAETANO, V. M.; TAKIUTI, J. T.; LAVEZZO, M. M.; OYAMADA, M. K.; HIRATA, C. E.conferenceObject Retinal vasculitis (RV) in pediatric population: case series(2020) GIAMPIETRO, Barbara; SOUTO, Fernanda Maria Silveira; TAKIUTI, Julia Tieme; CAMPOS, Lucia Maria Arruda; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce H.- Stem cell therapy and regenerative medicine in RPE degenerative disease: advances and challenges(2018) TAKIUTI, Julia T.; TAKAHASHI, Vitor K. L.; APATOFFA, Mary Ben L.; TSANG, Stephen H.Introduction: Retinal degenerative disorders affect patients of all age groups and cause devastating, irreversible vision loss. To date there is no effective treatment capable of restoring retinal function. Pluripotent stem cells, like embryonic stem cells and induced pluripotent stem cells, have the capacity to differentiate into any cell derived from the three germinal layers, including retinal tissue. Considering that, research in transplanted retinal cells derived from pluripotent stem cells has shown progressive results. Areas covered: The article discusses recent relevant clinical trials in retinal pigment epithelium-derived embryonic stem cells and -induced pluripotent stem cells, as well as challenges stem cell research faces from bench to bed side. Expert commentary: Therapies involving stem cells and regenerative medicine have the potential to restore sight and revolutionize the treatment of retinal disease. Clinical trials show promising results. Research surrounding obstacles and challenges is underway.
conferenceObject Changes in quality of life (QoL) in a 24-month interval in patients with non-acute Vogt-Koyanagi-Harada disease (VKHD)(2022) SOUTO, Fernanda Maria Silveira; MISSAKA, Ruy Felippe; LAVEZZO, Marcelo Mendes; NOBREGA, Priscilla Figueiredo; SAKATA, Viviane Mayumi; MAGALHAES, Breno Marchiori; CAETANO, Victor Marcos Couto; TAKIUTI, Julia Thiemi; OYAMADA, Maria Kiyoko; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce H.- Structural disease progression in PDE6-associated autosomal recessive retinitis pigmentosa(2018) TAKAHASHI, Vitor K. L.; TAKIUTI, Julia T.; JAUREGUI, Ruben; LIMA, Luiz H.; TSANG, Stephen H.Background and objective: To evaluate the progression of retinitis pigmentosa (RP) caused by mutations in either PDE6A or PDE6B by measuring the progressive constriction of the hyperautofluorescent ring and shortening of the ellipsoid zone (EZ)-line width. Patients and methods: Fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) images were obtained from seven patients with autosomal recessive RP caused by mutations in either PDE6A or PDE6B. Measurements of the EZ line width on SD-OCT images and horizontal, vertical diameter, and ring area on FAF images were performed by two independent graders. The measurements of these four parameters were correlated with one another. Results: We observed that the EZ line width decreased by an average of 91 +/- 64 mu m per year, while the horizontal and vertical diameters decreased by 103 +/- 53 mu m and 92 +/- 49 mu m per year, respectively. The ring area decreased by a rate of 0.3 +/- 0.18 mm(2) per year. Progression rates were similar for the left eye. Conclusions: We observed a progressive loss of EZ line width and Short-wavelength fundus autofluorescence (SW-AF) ring constriction over time. These results may serve as reference for better prognostic prediction and patients selection for clinical trials promoting cone rescue.
- Comparison of structural progression between ciliopathy and non-ciliopathy associated with autosomal recessive retinitis pigmentosa(2019) TAKAHASHI, Vitor K. L.; XU, Christine L.; TAKIUTI, Julia T.; APATOFF, Mary Ben L.; DUONG, Jimmy K.; MAHAJAN, Vinit B.; TSANG, Stephen H.BackgroundTo evaluate and compare the progression of ciliopathy and non-ciliopathy autosomal recessive Retinitis Pigmentosa patients (arRP) by measuring the constriction of hyperautofluorescent rings in fundus autofluorescence (FAF) images and the progressive shortening of the ellipsoid zone line width obtained by spectral-domain optical coherence tomography (SD-OCT).ResultsFor the ciliopathy group, the estimated mean shortening of the ellipsoid zone line was 259 mu m per year and the ring area decreased at a rate of 2.46mm(2) per year. For the non-ciliopathy group, the estimated mean shortening of the ellipsoid zone line was 84 mu m per year and the ring area decreased at a rate of 0.7mm(2) per year.ConclusionsOur study was able to quantify and compare the loss of EZ line width and short-wavelength autofluorescence (SW-AF) ring constriction progression over time for ciliopathy and non-ciliopathy arRP genes. These results may serve as a basis for modeling RP disease progression, and furthermore, they could potentially be used as endpoints in clinical trials seeking to promote cone and rod survival in RP patients.
conferenceObject Analysis of pattern and clinical features of pediatric uveitis cases at a tertiary referral center in Sao Paulo, Brazil(2018) GIAMPIETRO, Barbara; SOUTO, Fernanda Maria Silveira; TAKIUTI, Julia Thiemi; CAMPOS, Lucia Maria Arruda; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce H.conferenceObject Impact of inflammation and treatment on quality of life (QoL) in patients with Vogt-Koyanagi-Harada disease (VKHD)(2019) SOUTO, Fernanda Maria Silveira; MISSAKA, Ruy Felippe Brito Goncalves; TAKIUTI, Julia Thiemi; MAGALHAES, Breno Marchiori; CAETANO, Victor Marques Couto; LAVEZZO, Marcelo Mendes; OYAMADA, Maria Kiyoko; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce Hisae- Multimodal structural disease progression of retinitis pigmentosa according to mode of inheritance(2019) JAUREGUI, Ruben; TAKAHASHI, Vitor K. L.; PARK, Karen Sophia; CUI, Xuan; TAKIUTI, Julia T.; CARVALHO JR., Jose Ronaldo Lima de; TSANG, Stephen H.We analyze disease progression in retinitis pigmentosa (RP) according to mode of inheritance by quantifying the progressive decrease of the ellipsoid zone (EZ) line width on spectral domain optical coherence tomography (SD-OCT) and of the dimensions of the hyperautofluorescent ring on short-wave fundus autofluorescence (SW-FAF). In this retrospective study of 96 patients, average follow-up time was 3.2 +/- 1.9 years. EZ line width declined at a rate of -123 +/- 8 mu m per year, while the horizontal diameter and ring area declined at rates of -131 +/- 9 mu m and -0.5 +/- 0.05 mm(2) per year, respectively. Disease progression was found to be slowest for autosomal dominant RP and fastest for X-linked RP, with autosomal recessive RP progression rates between those of adRP and XLRP. EZ line width and ring diameter rates of disease progression were significantly different between each mode of inheritance. By using EZ line width and horizontal diameter as parameters of disease progression, our results confirm that adRP is the slowest progressing form of RP while XLRP is the fastest. Furthermore, the reported rates can serve as benchmarks for investigators of future clinical trials for RP and its different modes of inheritance.