JUSSARA BIANCHI CASTELLI

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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Agora exibindo 1 - 10 de 21
  • conferenceObject
    Challenges in Diagnosis and Treatment of Systemic Amyloidosis: 10 Years of Experience in a Public Brazilian University Center
    (2020) SZOR, Roberta Shcolnik; FERNANDES, Fabio; SEGURO, Fernanda S.; LINO, Angelina M.; JORGE, Lecticia B.; MENDONCA, Leonardo O.; FEITOSA, Valkercyo A.; CASTELLI, Jussara B.; REGO, Eduardo M.; JACOMASSI, Mayara; ALVES, Lucas B. O.; MARTINEZ, Gracia; ROCHA, Vanderson
  • article 6 Citação(ões) na Scopus
    Acute megakaryoblastic leukemia with t(1;22)(p13.3;q13.1); RBM15-MKL1 mimicking hepatoblastoma in an infant: The role of karyotype in differential diagnosis
    (2020) MARQUES-PIUBELLI, Mario L.; CORDEIRO, Maria Gabriella; CRISTOFANI, Lilian; BARROSO, Rodrigo de Souza; PAES, Vitor Ribeiro; CASTELLI, Jussara Bianchi; VELLOSO, Elvira Deolinda Rodrigues Pereira
  • conferenceObject
    Oral leukoplakia in chronic graft versus host disease
    (2012) PAVESI, V. C. S.; FRANCA, C. M.; CASTELLI, J. B.; SABOYA, R.; DULLEY, F. L.; CORACIN, F. L.
    Introduction: Late complications of allogeneic hematopoietic stem cell transplantation (HSCT) include a risk of secondary malignancies and early diagnosis of oral premalignant or malignant lesions requires an assessment of potential predisposing risk factors. Patients with oral epithelial dysplasia after allogeneic HSCT include oral cGVHD as a potential risk factor for oral cancer. A better understanding of the clinical features and potential factors associated with secondary oral cancer, may be benefit predicting and identifying this late complication of allogeneic HSCT. Case details: A 37 years old male who had received an allogeneic hematopoietic stem cell transplantation in October/2002 was referred to a Oral Medicine Outpatient in August 2011 with a white-plaque lesion of the oral mucosa the conditioning regimen to HSCT comprised busulfan-melphalan and graft-versus-host disease prophylaxis was cyclosporine-methotrexate. The patient developed lichenoid-oral cGVHD around day 60 and treatment comprised corticosteroid-cyclosporine. Clinical examination revealeda non-symptomatic 2 cm white-plaque of the hard palate. Exfoliative cytology was performed and no atypical cells were seen. The lesion increased in size to 4 cm long during the next 10-days. An incisional biopsy was undertaken and histopathological analysis revealed an epithelial tissue with acanthosis, hypergranulosis, hyperkeratosis, papilomatosis and apoptosis plus lymphocyte exocitosis. No atypical, cell dysplasia or koylocites were present. Mild to moderate cGVHD activity was seen. In this case, the patient was monitored in our outpatient program and no changes were noted in the lesion. Conclusion: The associationbetweenchronic graftversus host disease andoralsquamous cell carcinoma suggests a close monitoring of patients for early diagnosis of possible secondaryneoplasmsanddemonstratestheaggressivebehaviourofthislatecomplication. Relevance: Due to this aggressive behaviour and the increase number of HSCT worldwide, careful long-term follow-up by a cancer team, including oral medicine expertise, is recommended, and patients should be aware of cancer risk.
  • conferenceObject
    18F-FDG PET/CT Findings vs. Histology of Surgically Resected Cardiac Valves in Patients With Infective Endocarditis.
    (2018) CAMARGO, Raphael A.; CASTELLI, Jussara B.; BITTENCOURT, Marcio S.; AYABE, Daniel; PAIXAO, Milena R.; FELICIO, Marilia F.; SOEIRO, Alexandre M.; GONCALVES, Luis Fernando T.; V, Tania Strabelli; SOARES JR., Jose; BUCHPIGUEL, Carlos A.; MANSUR, Alfredo J.; TARASOUTCHI, Flavio; OLIVEIRA JR., Mucio T.; MENEGHETTI, Claudio; GUALANDRO, Daniele M.; POCEBON, Lucas; BLANKSTEIN, Ron; ALAVI, Abass; SICILIANO, Rinaldo F.
  • bookPart 0 Citação(ões) na Scopus
    Proteomics by Mass Spectrometry in the Typing of Amyloidosis
    (2023) CASTELLI, J. B.; CARVALHO, V. M.
    In this chapter, we will see how to accurately know the type of protein composing the amyloid deposit, remove it from the affected tissue, and analyze it with mass spectrometry proteomics to conduct the appropriate treatment. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.
  • article 3 Citação(ões) na Scopus
    Fatal adenoviral necrotizing bronchiolitis case in a post-cardiac surgery intensive care unit
    (2011) CASTELLI, Jussara Bianchi; SICILIANO, Rinaldo F.; VIEIRA, Ricardo D.; AIELLO, Vera D.; STRABELLI, Tania M. V.
    We report a case of a 67 year-old-male patient admitted to the intensive care unit in the post-coronary bypass surgery period who presented cardiogenic shock, acute renal failure and three episodes of sepsis, the latter with pulmonary distress at the 30th post-operative day. The patient expired within five days in spite of treatment with vancomycin, imipenem, colistimethate and amphotericin B. At autopsy severe adenovirus pneumonia was found. Viral pulmonary infections following cardiovascular surgery are uncommon. We highlight the importance of etiological diagnosis to a correct treatment approach.
  • article 20 Citação(ões) na Scopus
    Community-acquired culture-negative endocarditis: clinical characteristics and risk factors for mortality
    (2014) SICILIANO, Rinaldo Focaccia; MANSUR, Alfredo Jose; CASTELLI, Jussara Bianchi; ARIAS, Vanessa; GRINBERG, Max; LEVISON, Matthew E.; STRABELLI, Tania Mara Varejao
    Objectives: We studied the clinical characteristics, in-hospital mortality, and long-term prognosis of patients with culture-negative endocarditis. Methods: In total, 221 episodes of definite endocarditis were studied (2004-2009). We compared the clinical, laboratory, and echocardiography characteristics and the survival rates of patients with culture-negative and culture-positive endocarditis. Survival after hospital discharge was evaluated using the Kaplan-Meier method and coefficient of mortality comparisons. Results: Culture-negative endocarditis occurred in 51/221 (23.1%) episodes. Compared with the culture-positive endocarditis patients, the time elapsed between admission and initiation of antibiotic therapy was longer in patients with culture-negative endocarditis (p < 0.001), and these patients also had lower C-reactive protein levels at admission (p < 0.001). In-hospital mortality rates were not different between culture-negative and culture-positive patients. After hospital discharge, there was also no significant difference between groups in survival curves (p = 0.471). Severe sepsis (adjusted prevalence ratio 3.32, p = 0.010) and diabetes mellitus (adjusted prevalence ratio 2.32, p = 0.009) were independently associated with in-hospital death in culture-negative patients. Conclusions: Culture-negative endocarditis patients presented with lower levels of C-reactive protein at admission and required more time for initiation of antibiotic therapy, although there was no difference in in-hospital mortality or long-term survival between culture-negative and culture-positive endocarditis patients. Diabetes mellitus and severe sepsis were associated with in-hospital death in patients with culture-negative endocarditis. (C) 2014 The Authors.
  • article 4 Citação(ões) na Scopus
    Autopsy findings in a patient with primary systemic AL (Kappa light chain) amyloidosis
    (2021) LEDESMA, F. L.; CASTELLI, J. B.
    First described by Rokitansky in 1842, and further characterized by Virchow in 1854, amyloidosis is a disorder caused by amyloid deposition, a fibrillary insoluble protein. The clinical spectrum of amyloidosis is broad, as the amyloid deposition may virtually occur in all tissues. Herein, we report the case of a 66-year-old man with a long-lasting emaciating disease, diagnosed, at autopsy, with primary systemic amyloidosis. Amyloid protein deposition was found in many tissues and organs. The involvement of the vessels’ wall rendered ischemic injury most prominent in the intestinal loops causing mesenteric ischemia. Despite the thorough organic involvement, the immediate cause of death was aspiration bronchopneumonia. Massive amyloid deposition was found in virtually all major organs, such as the heart, liver, kidneys, spleen, pancreas, adrenals, prostate, skin, and thyroid: the latter, a complication of the amyloidosis known as amyloid goiter. Post-mortem review of the deceased’s laboratory workup showed a slightly abnormal kappa:lambda ratio in the blood; however, no clonal lymphoplasmacytic disorder was confirmed in the bone marrow and other lymphoreticular system organs either by the microscopic examination and immunohistochemical staining. Laser-capture microdissection and tandem mass spectrometry of the splenic tissue detected a peptide profile consistent with an immunoglobulin Kappa light chain. The presence of amyloid purpura favors the diagnosis of primary systemic amyloidosis. © 2021 The Authors.
  • article 1 Citação(ões) na Scopus
    Age, Blasts, Performance Status and Lenalidomide Therapy Influence the Outcome of Myelodysplastic Syndrome With Isolated Del(5q): A Study of 58 South American Patients
    (2022) AZEVEDO, R. S.; BELLI, C.; BASSOLLI, L.; FERRI, L.; PERUSINI, M. A.; ENRICO, A.; PEREIRA, T. D. M.; JUNIOR, W. F. S.; BUCCHERI, V; PINHEIRO, R. F.; MAGALHAES, S. M.; SCHUSTER, S.; CASTELLI, J. B.; TRAINA, F.; ROCHA, V; VELLOSO, E. D. R. P.
    This study analyzed the overall survival (OS) of patients with Myelodysplastic Syndrome (MDS) with isolated deletion 5q in South America. Age >75 years, ECOG >= 2 and Bone marrow (BM) blasts >2% at diagnosis is independently associated with worse OS. Lenalidomide treatment is the only factor that improves the OS. Background: Myelodysplastic Syndrome (MDS) with isolated deletion 5q is associated with a low risk to leukemic evolution and long overall survival (OS); it comprises 3%-4.5% of MDS cases in Latin America classified according to the World Health Organization 2008. This study aims to describe clinical, laboratory and the outcome of patients according to the newest World Health Organization 2016 proposal. Methods: We retrospectively reviewed patients from four Brazilian (BR) and four Argentinean (AR) centers diagnosed between 1999 and 2019. Results: The 58 patients (16-AR and 42-BR) presented a median age of 67 (IQR 61-75) years old, women predominance (70.7%) and transfusion dependency (62.5%) at diagnosis. Median hemoglobin level was 8.1g/dL, 27.5% and 44.4% presented thrombocytosis and neutropenia, respectively. Bone marrow (BM) was predominantly hypercellular (43.1%) with 66% showing dysplasia >1 lineage and 37.9% with >2% of blasts. Deletion 5q was mostly isolated (79.3%) and a variety of abnormalities were observed in remaining cases. Most patients were treated with erythropoietin-stimulating agents (ESA), 18 with lenalidomide and 15 with thalidomide. Median follow-up was 7.6 years, with a median OS of 3.5 years and an 8-years leukemic evolution rate of 18.4%. Multivariate analysis showed that age >75 years (HR 2.19), ECOG =2 (HR 5.76), BM blasts >2% (HR 2.92) and lenalidomide treatment (HR 0.25) independently influenced the OS. Conclusion: Older age, worse performance status and higher percentage of blasts, that can be easily assessed, were associated to a worse prognosis. Also, our results corroborate the protective influence of lenalidomide in terms of OS in this South American series.
  • article 21 Citação(ões) na Scopus
    Bartonella spp. and Coxiella burnetii Associated with Community-Acquired, Culture-Negative Endocarditis, Brazil
    (2015) SICILIANO, Rinaldo Focaccia; CASTELLI, Jussara Bianchi; MANSUR, Alfredo Jose; SANTOS, Fabiana Pereira dos; COLOMBO, Silvia; NASCIMENTO, Elvira Mendes do; PADDOCK, Christopher D.; BRASIL, Roosecelis Araujo; VELHO, Paulo Eduardo Neves Ferreira; DRUMMOND, Marina Rovani; GRINBERG, Max; STRABELLI, Tania Mara Varejao
    We evaluated culture-negative, community-acquired endocarditis by using indirect immunofluorescent assays and molecular analyses for Bartonella spp. and Coxiella burnetii and found a prevalence of 19.6% and 7.8%, respectively. Our findings reinforce the need to study these organisms in patients with culture-negative, community-acquired endocarditis, especially B. henselae in cat owners.