RENATO ANGHINAH
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
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- Integrative parietal cortex processes: Neurological and psychiatric aspects(2014) TEIXEIRA, Silmar; MACHADO, Sergio; VELASQUES, Bruna; SANFIM, Antonio; MINC, Daniel; PERESSUTTI, Caroline; BITTENCOURT, Juliana; BUDDE, Henning; CAGY, Mauricio; ANGHINAH, Renato; BASILE, Luis F.; PIEDADE, Roberto; RIBEIRO, Pedro; DINIZ, Claudia; CARTIER, Consuelo; GONGORA, Mariana; SILVA, Farmy; MANAIA, Femanda; SILVA, Julio GuilhermeFor many decades the parietal cortex (PC) has been considered the key area in tasks which involve the integration of different stimuli. PC is fundamental to determine spatial sense, information navigation and integration, and is involved in several aspects of the complex motor repertoire and in neurological and psychiatric disorders. In this review, we focus on seven different aspects of PC: (i) neuroanatomy of the parietal cortex; (ii) sensory motor integration processes; iii) hand movement control: reaching, grasping, and pointing; (iv) saccadic eye movements; (v) movement observation; (vi) neurological aspects: ataxia, autism and Parkinson's disease; and (vii) psychiatric aspects: schizophrenia, bipolar disorder and depression. Among these, we related the perspectives which involve the functions of the parietal cortex and mirror neurons and that seem to play a fundamental role in action prediction, planning, observation and execution. Furthermore, we focused on the relationship between posterior parietal cortex (PPC) and hand-guided movements. For this review, we conducted an academic paper search which fulfilled the objective of the study. We conclude that the PC has great participation in different motor functions and neurological/psychiatric disorders.
article 25 Citação(ões) na Scopus Sensorimotor integration and psychopathology: Motor control abnormalities related to psychiatric disorders(2011) VELASQUES, Bruna; MACHADO, Sergio; PAES, Flavia; CUNHA, Marlo; SANFIM, Antonio; BUDDE, Henning; CAGY, Mauricio; ANGHINAH, Renato; BASILE, Luis F.; PIEDADE, Roberto; RIBEIRO, PedroObjectives. Recent evidence is reviewed to examine relationships among sensorimotor and cognitive aspects in some important psychiatry disorders. This study reviews the theoretical models in the context of sensorimotor integration and the abnormalities reported in the most common psychiatric disorders, such as Alzheimer's disease, autism spectrum disorder and squizophrenia. Methods. The bibliographical search used Pubmed/Medline, ISI Web of Knowledge, Cochrane data base and Scielo databases. The terms chosen for the search were: Alzheimer's disease, AD, autism spectrum disorder, and Squizophrenia in combination with sensorimotor integration. Fifty articles published in English and were selected conducted from 1989 up to 2010. Results. We found that the sensorimotor integration process plays a relevant role in elementary mechanisms involved in occurrence of abnormalities in most common psychiatric disorders, participating in the acquisition of abilities that have as critical factor the coupling of different sensory data which will constitute the basis of elaboration of consciously goal-directed motor outputs. Whether these disorders are associated with an abnormal peripheral sensory input or defective central processing is still unclear, but some studies support a central mechanism. Conclusion. Sensorimotor integration seems to play a significant role in the disturbances of motor control, like deficits in the feedforward mechanism, typically seen in AD, autistic and squizophrenic patients.- Effectiveness of anodal transcranial direct current stimulation to improve muscle strength and motor functionality after incomplete spinal cord injury: a systematic review and meta-analysis(2020) ARAUJO, Amanda Vitoria Lacerda De; RIBEIRO, Felipe Piccarone Goncalves; MASSETTI, Thais; POTTER-BAKER, Kelsey A.; CORTES, Mar; PLOW, Ela Bhatt; SILVA, Talita Dias Da; TONKS, James; ANGHINAH, Renato; MAGALHAES, Fernando Henrique; FREGNI, Felipe; MONTEIRO, Carlos Bandeira De MelloStudy design Systematic review and meta-analysis. Objectives We aimed to investigate the effects of anodal transcranial direct current stimulation (tDCS) against sham on muscle strength and motor functionality after incomplete spinal cord injury (iSCI). Setting University of Sao Paulo, Brazil. Methods A preplanned protocol was registered (PROSPERO, CRD42016050444). Pubmed, Embase, Web of Science, Cochrane Central Library and BVS databases were searched independently by two authors up to March 2018. Cochrane Collaboration's Tool was used for the risk of bias assessments. Generic inverse variance and random-effects model were used to calculate pooled effect sizes (ES), 95% confidence intervals (CIs) and p-values in meta-analyses. Results Six randomized clinical trials met inclusion criteria (n = 78 iSCI individuals) and were included in the meta-analysis. Results showed a marginal significant pooled effect of active tDCS in improving motor functionality with a small ES (SMD = 0.26, 95% CI = -0.00 to 0.53, p = 0.05, I-2 = 0%). On the other hand, the pooled effect of active tDCS on muscle strength did not reach statistical significance, in parallel with a small ES (SMD = 0.35, 95% CI = -0.21 to 0.92, p = 0.22, I-2 = 0%) when compared with sham tDCS. No significant adverse events were reported. Conclusions Overall, there was a significant effect of tDCS in improving motor functionality following iSCI. However, a small ES and the marginal p-value suggest that these results should be interpreted with caution. Further high-quality clinical trials are needed to support or refute the use of tDCS in daily clinical practice.
- Fitness-to-drive after adult civilian traumatic brain injury: protocol for a systematic review and meta-analysis(2023) FIEDLER, Augusto Mueller; ALMEIDA, Timoteo; VASCONCELLOS, Fernando De Nigris; MORELL, Alexis; MONACO, Bernardo Assumpcao de; ANGHINAH, Renato; CORDEIRO, Joacir GraciolliTraumatic brain injury (TBI) poses significant challenges for assessing fitness-to-drive (FTD) and determining the appropriate timing for return-to-driving (RTD) in civilian adults. This systematic review and meta-analysis protocol is designed to offer a comprehensive assessment of RTD timelines post-TBI, examining the effects of injury severity as well as demographic and clinical factors that influence driving capabilities. In response to gaps identified in previous literature-namely, the absence of recent systematic search strategies and thorough quality assessments-this study employs rigorous methodologies for literature search, data extraction, and evaluation of study quality. Our approach aims to provide reliable estimates and detailed analyses of subgroups within the TBI population. The findings aim to support clinical decision-making, inform RTD readiness, and potentially impact policy and driving assessment protocols. Ultimately, this review seeks to contribute to public safety measures, reduce traffic-related harm, and improve life outcomes for individuals recovering from TBI, thereby filling a vital research niche in neurotrauma rehabilitation.