RENATO ANGHINAH

(Fonte: Lattes)
Índice h a partir de 2011
19
Lattes
ORCID
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

Indexador: PubMed ×

Resultados de Busca

Agora exibindo 1 - 10 de 21
  • conferenceObject
    Recurrent visits to the Emergency Department (ED) due to Headache: economic burden and epidemiological profile
    (2019) SOUZA, Marcio Nattan P.; CALDERARO, Marcelo; OLIVEIRA, Ana Paula D. S.; KUBOTA, Gabriel T.; ZAMBON, Lucas S.; ANGHINAH, Renato; JORDAO, Mauricio R.
  • article 47 Citação(ões) na Scopus
    Traumatic brain injury: An EEG point of view
    (2017) IANOF, Jéssica Natuline; ANGHINAH, Renato
    ABSTRACT Traumatic brain injury (TBI) is a silent epidemic. Mild traumatic brain injury (mTBI) causes brain injury that results in electrophysiologic abnormalities visible on electroencephalography (EEG) recordings. The purpose of this brief review was to discuss the importance of EEG findings in traumatic brain injury. Relevant articles published during the 1996-2016 period were retrieved from Medline (PubMed). The keywords were in English and included ""traumatic brain injury"", ""EEG"" and ""quantitative EEG"". We found 460 articles, analyzed 52 and selected 13 articles. EEG after TBI shows slowing of the posterior dominant rhythm and increased diffuse theta slowing, which may revert to normal within hours or may clear more slowly over many weeks. There are no clear EEG or quantitative EEG (qEEG) features unique to mild traumatic brain injury. Although the literature indicates the promise of qEEG in reaching a diagnosis and indicating prognosis of mTBI, further study is needed to corroborate and refine these methods.
  • article 11 Citação(ões) na Scopus
    Comparative analysis of the electroencephalogram in patients with Alzheimer's disease, diffuse axonal injury patients and healthy controls using LORETA analysis
    (2017) IANOF, Jéssica Natuline; FRAGA, Francisco José; FERREIRA, Leonardo Alves; RAMOS, Renato Teodoro; DEMARIO, José Luiz Carlos; BARATHO, Regina; BASILE, Luís Fernando Hindi; NITRINI, Ricardo; ANGHINAH, Renato
    ABSTRACT Alzheimer's disease (AD) is a dementia that affects a large contingent of the elderly population characterized by the presence of neurofibrillary tangles and senile plaques. Traumatic brain injury (TBI) is a non-degenerative injury caused by an external mechanical force. One of the main causes of TBI is diffuse axonal injury (DAI), promoted by acceleration-deceleration mechanisms. Objective: To understand the electroencephalographic differences in functional mechanisms between AD and DAI groups. Methods: The study included 20 subjects with AD, 19 with DAI and 17 healthy adults submitted to high resolution EEG with 128 channels. Cortical sources of EEG rhythms were estimated by exact low-resolution electromagnetic tomography (eLORETA) analysis. Results: The eLORETA analysis showed that, in comparison to the control (CTL) group, the AD group had increased theta activity in the parietal and frontal lobes and decreased alpha 2 activity in the parietal, frontal, limbic and occipital lobes. In comparison to the CTL group, the DAI group had increased theta activity in the limbic, occipital sublobar and temporal areas. Conclusion: The results suggest that individuals with AD and DAI have impairment of electrical activity in areas important for memory and learning.
  • article 0 Citação(ões) na Scopus
  • article 58 Citação(ões) na Scopus
    Index of alpha/theta ratio of the electroencephalogram: a new marker for Alzheimer's disease
    (2013) SCHMIDT, Magali T.; KANDA, Paulo A. M.; BASILE, Luis F. H.; LOPES, Helder Frederico da Silva; BARATHO, Regina; DEMARIO, Jose L. C.; JORGE, Mario S.; NARDI, Antonio E.; MACHADO, Sergio; IANOF, Jessica N.; NITRINI, Ricardo; ANGHINAH, Renato
    Objective: We evaluated quantitative EEG measures to determine a screening index to discriminate Alzheimers disease (AD) patients from normal individuals. Methods: Two groups of individuals older than 50 years, comprising a control group of 57 normal volunteers and a study group of 50 patients with probable AD, were compared. EEG recordings were obtained from subjects in a wake state with eyes closed at rest for 30 min. Logistic regression analysis was conducted. Results: Spectral potentials of the alpha and theta bands were computed for all electrodes and the alpha/theta ratio calculated. Logistic regression of alpha/theta of the mean potential of the C3 and O1 electrodes was carried out. A formula was calculated to aid the diagnosis of AD yielding 76.4% sensitivity and 84.6% specificity for AD with an area under the ROC curve of 0.92. Conclusion: Logistic regression of alpha/theta of the spectrum of the mean potential of EEG represents a good marker discriminating AD patients from normal controls.
  • article 2 Citação(ões) na Scopus
    Level of knowledge and misconceptions about brain concussion in Brazilian adults
    (2021) ARAUJO, Amanda Vitoria Lacerda De; AREZA-FEGYVERES, Renata; GUARIGLIA, Carla Cristina; IANOF, Jessica Natuline; BARATHO, Regina Maria; DEMARIO, Jose Luiz Carlos; WATANABE, Rafael Gustavo Sato; ANGHINAH, Renato
    Background: Brain concussion (BC) is seen as a public health priority due to its high incidence and morbidity rate, among thousands of people around the world. There are needs for fast identification, accurate diagnosis and correct management in order to reduce the short and long-term problems relating to BC. Proper knowledge of BC in the population and among clinicians is a critical factor in achieving this. Objectives: To evaluate the level of self-reported BC knowledge and gaps/misconceptions, and to identify variables correlated with this level. Methods: A cross-sectional descriptive survey was performed. A Brain Concussion Knowledge Questionnaire (BCKQ) that had been created to capture data was widely distributed. Total scores, domain partial scores and percentages of correct and incorrect answers were calculated to ascertain the level of knowledge relating to BC. Results: The sample was formed by 1,247 Brazilian adults (age: 41.7 +/- 11.8 years). Partial scores of the BCKQ revealed the existence of poor knowledge and misconceptions in all domains of the questionnaire, especially regarding questions about recovery from and management of BC. Moderate correlations between BCKQ scores and professions (p=0.312; P=0.00) or previous brain concussion knowledge (p=0.489; P=0.00) were observed. In a multiple linear regression model, age, profession and sports practice were predictors of BC knowledge. Conclusion: This first study to analyze the level of BC knowledge in a sample of Brazilian adults suggests that poor knowledge and misconceptions are present. Thus, meaningful and useful information was provided by this study for developing health education programs about BC for the population in order to improve fast diagnosis and correct BC management.
  • article 0 Citação(ões) na Scopus
    NEUROTRAUMA: From Emergency Room to Back to Day-by-Day Life
    (2018) ANGHINAH, Renato; PAIVA, Wellingson Silva; FALK, Tiago Henrique; FREGNI, Felipe
  • article 1 Citação(ões) na Scopus
  • article 0 Citação(ões) na Scopus
    BPSD following traumatic brain injury
    (2013) ANGHINAH, Renato; FREIRE, Fabio Rios; COELHO, Fernanda; LACERDA, Juliana Rhein; SCHMIDT, Magali Taino; CALADO, Vanessa Tomé Gonçalves; IANOF, Jéssica Natuline; MACHADO, Sergio; VELASQUES, Bruna; RIBEIRO, Pedro; BASILE, Luis Fernando Hindi; PAIVA, Wellingson Silva; AMORIM, Robson Luis
    ABSTRACT Annually, 700,000 people are hospitalized with brain injury acquired after traumatic brain injury (TBI) in Brazil. Objective: We aim to review the basic concepts related to TBI, and the most common Behavioral and Psychological Symptoms of Dementia (BPSD) findings in moderate and severe TBI survivors. We also discussed our strategies used to manage such patients in the post-acute period. Methods: Fifteen TBI outpatients followed at the Center for Cognitive Rehabilitation Post-TBI of the Clinicas Hospital of the University of São Paulo were submitted to a neurological, neuropsychological, speech and occupational therapy evaluation, including the Mini-Mental State Examination. Rehabilitation strategies will then be developed, together with the interdisciplinary team, for each patient individually. Where necessary, the pharmacological approach will be adopted. Results: Our study will discuss options of pharmacologic treatment choices for cognitive, behavioral, or affective disorders following TBI, providing relevant information related to a structured cognitive rehabilitation service and certainly will offer an alternative for patients and families afflicted by TBI. Conclusion: Traumatic brain injury can cause a variety of potentially disabling psychiatric symptoms and syndromes. Combined behavioral and pharmacological strategies, in the treatment of a set of highly challenging behavioral problems, appears to be essential for good patient recovery.
  • article 3 Citação(ões) na Scopus
    Oculomotor, vestibular, reaction time, and cognitive tests as objective measures of neural deficits in patients post COVID-19 infection
    (2022) KELLY, Kevin M.; ANGHINAH, R.; KULLMANN, A.; ASHMORE, R. C.; SYNOWIEC, A. S.; GIBSON, L. C.; MANFRINATI, L.; ARAUJO, A. de; SPERA, R. R.; BRUCKI, S. M. D.; TUMA, R. L.; BRAVERMAN, A.; KIDERMAN, A.
    ObjectiveAn alarming proportion (>30%) of patients affected by SARS-CoV-2 (COVID-19) continue to experience neurological symptoms, including headache, dizziness, smell and/or taste abnormalities, and impaired consciousness (brain fog), after recovery from the acute infection. These symptoms are self-reported and vary from patient to patient, making it difficult to accurately diagnose and initiate a proper treatment course. Objective measures to identify and quantify neural deficits underlying the symptom profiles are lacking. This study tested the hypothesis that oculomotor, vestibular, reaction time, and cognitive (OVRT-C) testing using eye-tracking can objectively identify and measure functional neural deficits post COVID-19 infection. MethodsSubjects diagnosed with COVID-19 (n = 77) were tested post-infection with a battery of 20 OVRT-C tests delivered on a portable eye-tracking device (Neurolign Dx100). Data from 14 tests were compared to previously collected normative data from subjects with similar demographics. Post-COVID subjects were also administered the Neurobehavioral Symptom Inventory (NSI) for symptom evaluation. ResultsA significant percentage of post COVID-19 patients (up to 86%) scored outside the norms in 12 out of 14 tests, with smooth pursuit and optokinetic responses being most severely affected. A multivariate model constructed using stepwise logistic regression identified 6 metrics as significant indicators of post-COVID patients. The area under the receiver operating characteristic curve (AUC) was 0.89, the estimated specificity was 98% (with cutoff value of 0.5) and the sensitivity was 88%. There were moderate but significant correlations between NSI domain key variables and OVRT-C tests. ConclusionsThis study demonstrates the feasibility of OVRT-C testing to provide objective measures of neural deficits in people recovering from COVID-19 infection. Such testing may serve as an efficient tool for identifying hidden neurological deficits post COVID-19, screening patients at risk of developing long COVID, and may help guide rehabilitation and treatment strategies.