BRUNA DEL GUERRA DE CARVALHO MORAES
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/49 - Laboratório de Protozoologia, Hospital das Clínicas, Faculdade de Medicina
LIM/49 - Laboratório de Protozoologia, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Synbiotic Supplementation Modulates Gut Microbiota, Regulates beta-Catenin Expression and Prevents Weight Gain in ob/ob Mice: Preliminary Findings(2022) DUARTE, Sebastiao Mauro B.; STEFANO, Jose Tadeu; FRANCO, Lucas A. M.; MARTINS, Roberta C.; MORAES, Bruna D. G. C.; BARBEIRO, Denise Frediani; OLIVEIRA, Nathalia; NERI, Junia Marielle Teixeira Rodrigues; COGLIATI, Bruno; VANNI, Denise Siqueira; SABINO, Ester C.; CARRILHO, Flair J.; OLIVEIRA, Claudia P.Background: Obesity is one of the main health problems in the world today, and dysbiosis seems to be one of the factors involved. The aim of this study was to examine the impact of synbiotic supplementation on obesity and the microbiota in ob/ob mice. Twenty animals were divided into four groups: obese treated (OT), obese control (OC), lean treated (LT) and lean control (LC). All animals received a standard diet for 8 weeks. The treated groups received a synbiotic (Simbioflora-Invictus Farmanutricao Ltd., Sao Paulo, Brazil) in water, while the nontreated groups received only water. After 8 weeks, all animals were sacrificed, and gut tissue and stool samples were collected for mRNA isolation and microbiota analysis, respectively. beta-Catenin, occludin, cadherin and zonulin in the gut tissue were analyzed via RT-qPCR. Microbiome DNA was extracted from stool samples and sequenced using an Ion PGM Torrent platform. Results: Synbiotic supplementation reduced body weight gain in the OT group compared with the OC group (p = 0.0398) and was associated with an increase in Enterobacteriaceae (p = 0.005) and a decrease in Cyanobacteria (p = 0.047), Clostridiaceae (p = 0.026), Turicibacterales (p = 0.005) and Coprococcus (p = 0.047). On the other hand, a significant reduction in Sutterella (p = 0.009) and Turicibacter (p = 0.005) bacteria was observed in the LT group compared to the LC group. Alpha and beta diversities were different among all treated groups. beta-Catenin gene expression was significantly decreased in the gut tissue of the OT group (p <= 0.0001) compared to the other groups. No changes were observed in occludin, cadherin or zonulin gene expression in the gut tissue. Conclusions: Synbiotic supplementation prevents excessive weight gain, modulates the gut microbiota, and reduces beta-catenin expression in ob/ob mice.
conferenceObject SWOT Analysis of a Tool for Data Management in Hematopoietic Stem Cell Transplantation(2020) OTUYAMA, Leonardo Jun; MORAES, Bruna Del Guerra de Carvalho; MARIANO, Livia; ROCHA, Vanderson- Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults(2020) BARBAN, Juliana Bernardo; SIMOES, Belinda Pinto; MORAES, Bruna Del Guerra de Carvalho; ANUNCIACAO, Cassia Rehem da; ROCHA, Cristiane Santos da; PINTOR, Daniela Cristina Querino; GUERRA, Daiane Cristina; SILVA, Deise Andrade; BRANDAO, Edith de Castro Martins; KERBAUY, Fabio; PIRES, Fernanda Ramos de Oliveira; MORAIS, Graciele Lima; SCHMIDT FILHO, Jayr; SICCHIERI, Juliana Maria Faccioli; BARROSO, Karine Sampaio Nunes; VIANA, Luciana Vercoza; ROCHA, Mariana Hollanda Martins da; GUIMARAES, Maysa Penteado; LAZZARI, Natalia Leonetti Couto; HAMERSCHLAK, Nelson; RAMOS, Patricia; GOMES, Plinio Nascimento; MENDONCA, Priscila da Silva; OLIVEIRA, Raquel Candido de; SCOMPARIM, Renata Correa; CHIATTONE, Ricardo; DIEZ-GARCIA, Rosa Wanda; CARDENAS, Thais de Campos; MIOLA, Thais Manfrinato; COSTA, Thalita Cristina de Mello; ROCHA, Vanderson; PEREIRA, Andrea Z.The nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutritional evaluation and follow-up during hematopoietic stem cell transplant are essential. To emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to the nutritional assessment of the patient, the Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplant: Adults was prepared, aiming to standardize and update Nutritional Therapy in this area. Dietitians, nutrition physicians and hematologists from 15 Brazilian centers thar are references in hematopoietic stem cell transplant took part.
bookPart Assistência nutricional no transplante de células-tronco hematopoiéticas(2023) MORAES, Bruna Del Guerra de Carvalho- Association of Sarcopenia with Toxicities and Survival after Autologous Hematopoietic Stem Cell Transplantation for Adults with Lymphomas(2018) NETO, Abel Costa; MORAES, Bruna Del Guerra Carvalho; ROCHA, Ilanna Marques Gomes; BEZERRA, Felipe Acquesta; MEDEIROS, Galtieri Otavio Cunha; ALVES, Lucas Bassolli Oliveira; ROSSETTI, Renata Ariza Marques; FAYH, Ana Paula Trussardi; MARIANO, Livia Caroline Barbosa; ROCHA, Vanderson