NATASHA MALO DE SENCO

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LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina

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  • article 51 Citação(ões) na Scopus
    Transcranial direct current stimulation in obsessive-compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes
    (2015) SENCO, Natasha M.; HUANG, Yu; D'URSO, Giordano; PARRA, Lucas C.; BIKSON, Marom; MANTOVANI, Antonio; SHAVITT, Roseli G.; HOEXTER, Marcelo Q.; MIGUEL, Euripedes C.; BRUNONI, Andre R.
    Background: Neuromodulation techniques for obsessive-compulsive disorder (OCD) treatment have expanded with greater understanding of the brain circuits involved. Transcranial direct current stimulation (tDCS) might be a potential new treatment for OCD, although the optimal montage is unclear. Objective: To perform a systematic review on meta-analyses of repetitive transcranianal magnetic stimulation (rTMS) and deep brain stimulation (DBS) trials for OCD, aiming to identify brain stimulation targets for future tDCS trials and to support the empirical evidence with computer head modeling analysis. Methods: Systematic reviews of rTMS and DBS trials on OCD in Pubmed/MEDLINE were searched. For the tDCS computational analysis, we employed head models with the goal of optimally targeting current delivery to structures of interest. Results: Only three references matched our eligibility criteria. We simulated four different electrodes montages and analyzed current direction and intensity. Conclusion: Although DBS, rTMS and tDCS are not directly comparable and our theoretical model, based on DBS and rTMS targets, needs empirical validation, we found that the tDCS montage with the cathode over the pre-supplementary motor area and extra-cephalic anode seems to activate most of the areas related to OCD.
  • conferenceObject
    Myo-Inositol Reduction in Medial Prefrontal Cortex of Obsessive Compulsive Disorder: A Proton Magnetic Resonance Spectroscopy Study
    (2015) BATISTUZZO, Marcelo; HOEXTER, Marcelo; COSTA, Fabiana; SHAVITT, Roseli; LOPES, Antonio; CAPPI, Carolina; MATHIS, Alice De; NATASHA, Senc O.; HENNING, Anke; PASTORELLO, Bruno; LEITE, Claudia; MIGUEL, Euripedes; OTADUY, Maria
  • article 0 Citação(ões) na Scopus
    Transcranial direct current stimulation in psychiatric disorders
    (2015) TORTELLA, Gabriel; CASATI, Roberta; APARICIO, Luana V. M.; MANTOVANI, Antonio; SENCO, Natasha; D'URSO, Giordano; BRUNELIN, Jerome; GUARIENTI, Fabiana; SELINGARDI, Priscila Mara Lorencini; MUSZKAT, Debora; PEREIRA JUNIOR, Bernardo de Sampaio; VALIENGO, Leandro; MOFFA, Adriano H.; SIMIS, Marcel; BORRIONE, Lucas; BRUNONI, Andre R.
    The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation (tDCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally, we provide an overview of tDCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding tDCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding tDCS efficacy in psychiatry.