GERHARD DA PAZ LAUTERBACH
Projetos de Pesquisa
Unidades Organizacionais
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
14 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 14
bookPart Estudos de não inferioridade(2017) LAUTERBACH, Gerhard da PazbookPart Ensaios clínicos(2023) LAUTERBACH, Gerhard da Paz; JúNIOR, Flávio Araújo BorgesbookPart Parasitoses Intestinais(2015) THOMAZ, Daniela; LAUTERBACH, Gerhard da Paz; HERBST, Lívia Grigoriitchuk; LIMA, Rafael Baima de Melo; HIRAMA, Sheila CristinabookPart Ensaios clínicos(2017) LAUTERBACH, Gerhard da Paz; JúNIOR, Flávio Araújo BorgesconferenceObject Baseline Knowledge Of Mechanical Ventilation Among Incoming Interns Participating In A Boot Camp Training Prior To Starting An Internal Medicine Residency Program In Brazil(2016) LIMA, R. B. M.; ZENI, E. M.; LAUTERBACH, G. D. P.; HERBST, L. G.; AYRES, P. P. M. R.; MIETHKE-MORAIS, A.; NUNES, M. P. T.; FERREIRA, J. C.- Comparative assessment of mortality risk factors between admission and follow-up models among patients hospitalized with COVID-19(2021) LAZAR NETO, Felippe; SALZSTEIN, Guilherme A.; CORTEZ, Andre L.; BASTOS, Thais L.; BAPTISTA, Fabiola V. D.; MOREIRA, Joanne A.; LAUTERBACH, Gerhard P.; OLIVEIRA, Julio Cesar de; ASSIS, Fabio C. de; AGUIAR, Marilia R. A.; DEUS, Aline A. de; DIAS, Marcos Felipe D. S.; SOUSA, Felipe C. B.; DUAILIBI, Daniel F.; KONDO, Rodrigo H.; MORAES, Augusto Cesar F. de; MARTINS, Milton A.Objectives: This study aimed to compare differences in mortality risk factors between admission and follow-up incorporated models. Methods: A retrospective cohort study of 524 patients with confirmed COVID-19 infection admitted to a tertiary medical center in S?o Paulo, Brazil from 13 March to 30 April 2020. Data were collected on admission, and the third, eighth and fourteenth days of hospitalization. The hazard ratio (HR) was calculated and 28-day in-hospital mortality risk factors were compared between admission and followup models using a time-dependent Cox regression model. Results: Of 524 patients, 50.4% needed mechanical ventilation. The 28-day mortality rate was 32.8%. Compared with follow-up, admission models under-estimated the mortality HR for peripheral oxygen saturation 92% (1.21 versus 2.09), heart rate 100 bpm (1.19 versus 2.04), respiratory rate >24/min (1.01 versus 1.82) and mechanical ventilation (1.92 versus 12.93). Low oxygen saturation, higher oxygen support and more biomarkers?including lactate dehydrogenase, C-reactive protein, neutrophillymphocyte ratio, and urea remained associated with mortality after adjustment for clinical factors at follow-up compared with only urea and oxygen support at admission. Conclusions: The inclusion of follow-up measurements changed mortality hazards of clinical signs and biomarkers. Low oxygen saturation, higher oxygen support, lactate dehydrogenase, C-reactive protein, neutrophil-lymphocyte ratio, and urea could help with prognosis of patients during follow-up. ? 2021 The Authors.
- Blood leukocyte transcriptional modules and differentially expressed genes associated with disease severity and age in COVID-19 patients(2023) BANDO, Silvia Y.; BERTONHA, Fernanda B.; VIEIRA, Sandra E.; OLIVEIRA, Danielle B. L. de; CHALUP, Vanessa N.; DURIGON, Edison L.; PALMEIRA, Patricia; CURI, Ana Cristina P.; FARIA, Caroline S.; ANTONANGELO, Leila; LAUTERBACH, Gerhard da P.; REGALIO, Fabiane A.; CESAR, Roberto M.; MOREIRA-FILHO, Carlos A.Since the molecular mechanisms determining COVID-19 severity are not yet well understood, there is a demand for biomarkers derived from comparative transcriptome analyses of mild and severe cases, combined with patients' clinico-demographic and laboratory data. Here the transcriptomic response of human leukocytes to SARS-CoV-2 infection was investigated by focusing on the differences between mild and severe cases and between age subgroups (younger and older adults). Three transcriptional modules correlated with these traits were functionally characterized, as well as 23 differentially expressed genes (DEGs) associated to disease severity. One module, correlated with severe cases and older patients, had an overrepresentation of genes involved in innate immune response and in neutrophil activation, whereas two other modules, correlated with disease severity and younger patients, harbored genes involved in the innate immune response to viral infections, and in the regulation of this response. This transcriptomic mechanism could be related to the better outcome observed in younger COVID-19 patients. The DEGs, all hyper-expressed in the group of severe cases, were mostly involved in neutrophil activation and in the p53 pathway, therefore related to inflammation and lymphopenia. These biomarkers may be useful for getting a better stratification of risk factors in COVID-19.
bookPart Introdução à medicina baseada em evidências(2023) LAUTERBACH, Gerhard da Paz- Human Leukocyte Transcriptional Response to SARS-CoV-2 Infection(2020) VIEIRA, Sandra Elisabete; BANDO, Silvia Yumi; LAUTERBACH, Gerhard da Paz; MOREIRA-FILHO, Carlos Alberto
- Patient Safety under Flexible and Standard Duty-Hour Rules(2019) LANDRIGAN, Christopher P.; CZEISLER, Charles A.; SQUIERS, John J.; LAUTERBACH, Gerhard P.; VALENTE, Fernando S.; NUNES, Maria P. T.