PATRICIA AZEVEDO SOARES CORDEIRO

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina

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  • article 3 Citação(ões) na Scopus
    The role of IFN-gamma production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
    (2022) CORDEIRO, Patricia Azevedo Soares; ASSONE, Tatiane; PRATES, Gabriela; TEDESCHI, Marcia Regina Martinez; FONSECA, Luiz Augusto Marcondes; CASSEB, Jorge
    Interferon-gamma (IFN-gamma) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-gamma in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-gamma during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.