GABRIELA ROMANENGHI FANTI CARVALHO ARAUJO GOUVEIA
Índice h a partir de 2011
1
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Study of two strategies to induce follicular wave emergence for assisted reproductive treatments (ART)-a preliminary trial(2015) BIANCHI, Paulo H. M.; VIERA, Lais M.; GOUVEIA, Gabriela R. F. C. A.; ROCHA, Andre M.; BARUSELLI, Pietro S.; BARACAT, Edmund C.; SERAFINI, Paulo C.This study aimed to induce follicular wave emergence (FWE) using pharmacological (recombinant hCG administration) or mechanical (aspiration of dominant follicle) interventions in infertile women. Sixteen infertile women (a parts per thousand currency sign35 years) with indications for in vitro fertilization due to tubal and/or male factor infertility were randomized into three groups: control (n = 6), pharmacological (n = 5) and mechanical (n = 5) groups. Women in both experimental groups underwent serial transvaginal sonograms (TVS) from menstrual cycle day 10 until identification of a dominant follicle a parts per thousand yen15 mm. Women in the pharmacological group received 250 mu g of recombinant-hCG to induce ovulation, and resumed serial TVS 2 days later. In the mechanical group, dominant and subordinate follicles a parts per thousand yen10 mm were aspirated, and daily TVS was resumed on the following day. An increased pool of follicles a parts per thousand yen5 and a parts per thousand currency sign9 mm after interventions characterized FWE. Women in the control group underwent ovulation induction (OI) with 150 IU/day of recombinant follicle-stimulating hormone started on menstrual cycle day 3 (D3). OI was started on the day of FWE in the experimental groups. Endometrial asynchrony with development of the embryo was expected in the experimental groups. Therefore, all viable embryos were cryopreserved and transferred in an endometrial-stimulated cycle. The number of follicles a parts per thousand yen5 and a parts per thousand currency sign9 mm increased after the interventions in both experimental groups (p < .001), indicating induction of FWE. OI outcomes were similar among the groups. The pharmacological and mechanical interventions are efficient in inducing FWE; outcomes of OI synchronized with FWE should be further investigated.
conferenceObject Successful Live Birth in a Female with 17-Hydroxylase Deficiency through IVF Frozen-Thawed Embryo Transfer after Adequate Endometrial Preparation(2014) BIANCHI, Paulo H. M.; GOUVEIA, Gabriela R. F. C. A.; DOMENICE, Sorahia; COSTA, Elaine M. F.; MARTIN, Regina M.; CARVALHO, Luciane C.; PELAES, Tatiana S.; CODARIN, Rodrigo R.; FARIA, Maria Beatriz S.; FRANCISCO, Rossana P. V.; BARACAT, Edmund Chada; SERAFINI, Paulo C.; MENDONCA, Berenice B.- Successful Live Birth in a Woman With 17 alpha-Hydroxylase Deficiency Through IVF Frozen-Thawed Embryo Transfer(2016) BIANCHI, Paulo Homem de Mello; GOUVEIA, Gabriela Romanenghi Fanti Carvalho Araujo; COSTA, Elaine M. Frade; DOMENICE, Sorahia; MARTIN, Regina M.; CARVALHO, Luciane Carneiro de; PELAES, Tatiana; INACIO, Marlene; CODARIN, Rodrigo Rocha; FARIA, Maria Beatriz Sator de; FRANCISCO, Rossana Pulcineli Vieira; BARACAT, Edmund Chada; SERAFINI, Paulo Cesar; MENDONCA, Berenice B.Context: Congenital adrenal hyperplasia (CAH) dueto 17 alpha-hydroxylase deficiency in 46,XX patients is characterized by primary amenorrhea, absent or incomplete sexual maturation, infertility, low serum levels of estradiol, and elevated progesterone (P). There were no previous reports of singleton live births from such women. Objective: To describe the first successful singleton live birth in a female with CAH due to 17 alpha-hydroxylase deficiency. Case Description: A 26-year-old Brazilian woman with CAH associated with 17 alpha-hydroxylase deficiency due to the compound heterozygote mutation (p.W406R/P428L) in the CYP17A1 gene expressed the desire to conceive. In vitro fertilization (IVF) was recommended due to the complexity of the disorder. The first attempt of treatment failed despite the production of viable embryos. At the second IVF attempt, all viable embryos were frozen due to inadequate endometrial development associated with prematurely elevated serum P during ovarian stimulation. Subsequently, a long-acting GnRH agonist and oral dexamethasone were used to lower ovarian and adrenal P overproduction. Once serum levels of P were < 1 ng/mL, endometrial preparation with estradiol valerate and frozen-thawed embryo transfer were performed, resulting in a singleton pregnancy. Estradiol supplementation was completely suspended by 14 weeks of gestation. She delivered at 30 weeks and 4 days due to acute fetal distress. The puerperium was uneventful; the newborn was discharged in good conditions 5 weeks after birth. Conclusion: A successful live birth was achieved in a woman with 17-hydroxylase deficiency through IVF, cryopreservation of all embryos, and frozen-thawed embryo transfer after adequate endometrial preparation.