IRIMAR DE PAULA POSSO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cirurgia, Faculdade de Medicina - Docente
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina
17 resultados
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- Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models(2012) SOUSA, A. M.; ASHMAWI, H. A.; COSTA, L. S.; POSSO, I. P.; SLULLITEL, A.Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg) increased both paw withdrawal latency in response to radiant heat (8.3 +/- 1.1, 12.7 +/- 1.8, 8.4 +/- 0.8, and 11.1 +/- 3.3 s) and mechanical threshold in response to von Frey filaments (459 +/- 82.8, 447.5 +/- 91.7, 320.1 +/- 120, 126.43 +/- 92.8 mN) at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg) blocked motor function as well as 2% lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics.
bookPart Legislação para a prática de anestesiologia(2017) POSSO, Irimar de Paula; CANGA, José Carlosarticle 49 Citação(ões) na Scopus Sex and Pain Perception and Analgesia(2011) PALMEIRA, Claudia Carneiro de Araujo; ASHMAWI, Hazem Adel; POSSO, Irimar de PaulaPalmeira CCA, Ashmawi HA, Posso IP - Sex and Pain Perception and Analgesia. Sex is an important factor in painful experience modulation. Large volume of evidence shows that experience is different for males and females, as well as the answer to some classes of analgesics. Laboratory experiments suggest that women have a lower pain threshold than men related to pain from noxious stimuli such as heat, cold, pressure and electrical stimulation. Pain is a dynamic phenomenon under the influence of various mechanisms of excitatory and inhibitory control. The differences in pain perception related to sex may be associated with hyperalgesia in women, but also to the hypoactivity of the inhibitory system of pain in females. The purpose of this review besides showing some relationship for gonadal hormones, central nervous system and pain is to provide reference points for the discussion of one of the most intriguing aspects of the pathophysiology of pain: the differences in the presence of painful stimuli related to gender.- Prevalence of Chronic Pain, Treatments, Perception, and Interference on Life Activities: Brazilian Population-Based Survey(2017) SOUZA, Juliana Barcellos de; GROSSMANN, Eduardo; PERISSINOTTI, Dirce Maria Navas; OLIVEIRA JUNIOR, Jose Oswaldo de; FONSECA, Paulo Renato Barreiros da; POSSO, Irimar de PaulaBackground and Objectives. Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. Methods. Cross-sectional study of a population-based survey with randomized sample from a private database. The interviews were conducted by phone. 78% of the respondents aged 18 years or more agreed to be interviewed, for a total of 723 respondents distributed throughout the country. Independent variables were demographic data, pain and treatment characteristics, and impact of pain on daily life. Comparative and associative statistical analyses were conducted to select variables for nonhierarchical logistic regression. Results. Chronic pain prevalence was 39% and mean age was 41 years with predominance of females (56%). We found higher prevalence of chronic pain in the Southern and Southeastern regions. Pain treatment was not specific to gender. Dissatisfaction with chronic painmanagement was reported by 49% of participants. Conclusion. 39% of interviewed participants reported chronic pain, with prevalence of females. Gender-associated differences were found in intensity perception and interference of pain on daily life activities.
- Changes in Purines Concentration in the Cerebrospinal Fluid of Pregnant Women Experiencing Pain During Active Labor(2015) SCHMIDT, Andre P.; BOEHMER, Ana E.; HANSEL, Gisele; SOARES, Felix A.; OSES, Jean P.; GIORDANI, Alex T.; POSSO, Irimar P.; AULER JR., Jose Otavio C.; MENDES, Florentino F.; FELIX, Elaine A.; PORTELA, Luis V.; SOUZA, Diogo O.Labor pain has been reported as a severe pain and can be considered as a model of acute visceral pain. It is well known that extracellular purines have an important role in pain signaling in the central nervous system. This study analyzes the relationship between extracellular purines and pain perception during active labor. A prospective observational study was performed. Cerebrospinal fluid (CSF) levels of the purines and their metabolites were compared between women at term pregnancy with labor pain (n = 49) and without labor pain (Caesarian section; n = 47). Control groups (healthy men and women without chronic or acute pain-n = 40 and 32, respectively) were also investigated. The CSF levels of adenosine were significantly lower in the labor pain group (P = 0.026) and negatively correlated with pain intensity measured by a visual analogue scale (r = -0.48, P = 0.0005). Interestingly, CSF levels of uric acid were significantly higher in healthy men as compared to women. Additionally, pregnant women showed increased CSF levels of ADP, GDP, adenosine and guanosine and reduced CSF levels of AMP, GTP, and uric acid as compared to non-pregnant women (P < 0.05). These findings suggest that purines, in special the nucleoside adenosine, are associated with pregnancy and labor pain.
bookPart Analgesia Pós-operatoria Ambulatorial(2017) ROMANEK, Roberto Monclùs; POSSO, Irimar de Paula; GATTO, Bruno Emanuel OlivabookPart Implicações legais do manejo anestésico(2013) KLEINE, Rodolpho Truffa; POSSO, Irimar de PaulaconferenceObject Influence of ageing and male gonads in pain perception in rats(2012) ASHMAWI, Hazem; POSSO, Irimar; BULLARA, Carolina; PALMEIRA, ClaudiaIntroduction: Pain is complex experience influenced by many factors. Among these factors, there are ageing process and gonadal hormones. The use of animal pain models allows the isolation of variables, facilitating the comprehension of the roles each factor has on pain. Objectives: Two experimental pain models were used, pain induced by formalin paw injection and plantar incision, to study the influence of ageing and male gonads on pain perception. Methods: Adult rats (6 months), aged rats (22 months), young non orchiectomized and orchiectomized rats were evaluated for the number of flinches after paw formalin injection and mechanical withdrawal threshold after plantar incision. Results: The results showed aged rats presented decreased number of flinches than adult rats during phase II of formalin induced behavior at 25, 30 and 35 minutes time points. Aged rats presented lower paw withdrawal threshold after mechanical stimulus in the plantar incision model, at 2nd, 3rd, 4th, 7th and 10th postoperative days, the return to baseline levels occurred after the 18th day in aged rats and after the 10th day in adult rats. Orchiectomized rats presented decreased number of flinches compared to non orchiectomized rats in the initial section of phase I, 5 minutes time point, and in phase II, at 25, 30, 35, 40, 45, 50, 55 and 60 minutes time points. In orchiectomized rats, paw withdrawal threshold was lower when compared to non orchiectomized rats on the 1st, 2nd, 4th and 7th postoperative days. Return to baseline values occurred after the 18th day in orchiectomized rats and after the 14th day in non orchiectomized rats. Conclusions: Data showed that pain perception changes with the ageing process according to the type of stimulus and that male gonads present analgesic effect on both pain models evaluated.- Once again, the job is done!(2021) POSSO, Irimar de Paula
bookPart Dor orofacial(2019) CORREIA, Luci Mara França; DURãO, Laís Kozminski da Costa Akcelrud; CORREIA FILHO, Rubens; POSSO, Irimar de Paula