EDUARDO FERRACIOLI ODA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
- Meta-Analysis: Reduced Risk of Anxiety with Psychostimulant Treatment in Children with Attention-Deficit/Hyperactivity Disorder(2015) COUGHLIN, Catherine G.; COHEN, Stephanie C.; MULQUEEN, Jilian M.; FERRACIOLI-ODA, Eduardo; STUCKELMAN, Zachary D.; BLOCH, Michael H.Objective: Anxiety is a commonly reported side-effect of psychostimulant treatment. Our goal was to quantify the risk of anxiety as a side effect of psychostimulant treatment for attention-deficit/hyperactivity disorder (ADHD). Methods: We conducted a PubMed search to identify all double-blind, randomized, placebo-controlled trials examining the efficacy of psychostimulant medications in the treatment of children with ADHD. We used a fixed-effects meta-analysis to examine the risk ratio of anxiety reported as a side effect in children treated with psychostimulants compared with those treated with placebo. We used stratified subgroup analysis and meta-regression to examine the effects of stimulant type, dosage, duration of use, and trial design on the measured risk of anxiety. Results: We identified 23 studies involving 2959 children with ADHD for inclusion in our meta-analysis. The risk of anxiety associated with psychostimulant treatment was significantly lower than that experienced with placebo (relative risk [RR]=0.86 [95% CI: 0.77, 0.95], z=-2.90, p<0.05). Higher doses of psychostimulants were associated with a reduced measured risk of anxiety of psychostimulants when compared with placebo (=-0.0039 [95% CI: -0.00718, -0.00064], z=-2.34, p=0.019). Conclusions: Meta-analysis suggests that treatment with psychostimulants significantly reduced the risk of anxiety when compared with placebo. This finding does not rule out the possibility that some children experience increased anxiety when treated with psychostimulants, but suggests that those risks are outweighed by the number of children who experience improvement in anxiety symptoms (possibly as a secondary effect of improved control of ADHD symptoms). Clinicians should consider rechallenging children with ADHD who report new-onset or worsening anxiety with psychostimulants, as these symptoms are much more likely to be coincidental rather than caused by psychostimulants.
conferenceObject Serotonin reuptake inhibitor augmentation with n-acetylcysteine in treatment resistant ocd: a double-blind randomized controlled trial(2015) COSTA, D. L. C.; DINIZ, J. B.; JOAQUIM, M.; ACCIARITO, A. C.; RODRIGUES, B.; ODA, E.; REQUENA, G.; MIGUEL, E. C.; SHAVITT, R. GedankeconferenceObject Clinical characteristics, outcome, and management of Staphylococcus epidermidis endophthalmitis(2019) TANAKA, Tatiana; KATO, Juliana Mika; OLIVEIRA, Luiza Manhezi Shin de Shin de; ODA, Eduardo Ferracioli; BARBOSA, Thaisa Silveira; ROSSI, Flavia; ALMEIDA JUNIOR, Joao Nobrega; YAMAMOTO, Joyce Hisae- Clinical relevance of protruded retinal layers in minimum rim width measurement of the optic nerve head(2019) TORRES, Lucas A.; JARRAR, Faisal; SHARPE, Glen P.; HUTCHISON, Donna M.; FERRACIOLI-ODA, Eduardo; HATANAKA, Marcelo; NICOLELA, Marcelo T.; VIANNA, Jayme R.; CHAUHAN, Balwantray C.Background/aims Optical coherence tomography (OCT) imaging of the optic nerve head minimum rim width (MRW) has recently been shown to sometimes contain components besides extended retinal nerve fibre layer (RNFL). This study was conducted to determine whether excluding these components, termed protruded retinal layers (PRLs), from MRW increases diagnostic accuracy for detecting glaucoma. Methods In this cross-sectional study, we included 123 patients with glaucoma and 123 normal age-similar controls with OCT imaging of the optic nerve head (24 radial scans) and RNFL (circle scan). When present, PRLs were manually segmented, and adjusted MRW measurements were computed. We compared diagnostic accuracy of adjusted versus unadjusted MRW measurement. We also determined whether adjusted MRW correlates better with RNFL thickness compared with unadjusted MRW. Results The median (IQR) visual field mean deviation of patients and controls was -4.4 (-10.3 to -2.1) dB and 0.0 (-0.6 to 0.8) dB, respectively. In the 5904 individual B-scans, PRLs were identified less frequently in patients (448, 7.6%) compared with controls (728, 12.3%; p<0.01) and were present most frequently in the temporal sector of both groups. Areas under the receiver operating characteristic curves and sensitivity values at 95% specificity indicated that PRL adjustment did not improve diagnostic accuracy of MRW, globally or temporally. Furthermore, adjusting MRW for PRL did not improve its correlation with RNFL thickness in either group. Conclusion While layers besides the RNFL are sometimes included in OCT measurements of MRW, subtracting these layers does not impact clinical utility.
- Clinical and epidemiological profile of patients with definite ocular sarcoidosis at a Brazilian referral center(2022) FERRACIOLI-ODA, Eduardo; KAWASSAKI, Alexandre de Melo; ARIMURA, Fabio Eiji; KAIRALLA, Ronaldo Adib; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce Hisae
conferenceObject Low-volume direct strip multiplex PCR of intraocular fluid in uveitis(2023) YAMAMOTO, Joyce H.; ODA, Eduardo Ferracioli; TANAKA, Tatiana; GOUVEA, Michele Soares Gomes; PINHO, Joao Renato Rebello; COELHO, Veronica; BISPO, Paulo J. M.; HIRATA, Carlos EduardoconferenceObject Serotonin Reuptake Inhibitor Augmentation with N-Acetylcysteine in Treatment Resistant Obsessive-Compulsive Disorder: A Double-blind Randomized Controlled Trial(2015) COSTA, Daniel L. C.; DINIZ, Juliana B.; JOAQUIM, Marines; ACCIARITO, Ana C.; RODRIGUES, Bernardo; ODA, Eduardo F.; REQUENA, Guaraci; MIGUEL, Euripedes C.; PITTENGER, Christopher; BLOCH, Michael H.; SHAVITT, Roseli G.conferenceObject Cytokines profile in ocular fluid of individuals with uveitis: preliminary result(2023) ODA, Eduardo Ferracioli; COELHO, Veronica; ANTONANGELO, Leila; HIRATA, Carlos Eduardo; YAMAMOTO, Joyce H.- Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis(2017) STUCKELMAN, Zachary D.; MULQUEEN, Jilian M.; FERRACIOLI-ODA, Eduardo; COHEN, Stephanie C.; COUGHLIN, Catherine G.; LECKMAN, James F.; BLOCH, Michael H.Objective: Irritability is listed as a common side effect of psychostimulant medications. However, psychostimulants have been demonstrated as an effective treatment in reducing irritability and aggression in children with attention-deficit/hyperactivity disorder (ADHD). The goal of this study was to quantify the risk of irritability as a side effect of psychostimulant treatment for ADHD. Data Sources and Study Selection: A PubMed search was conducted on August 18, 2013, to identify all double-blind, randomized, placebo-controlled trials published in English examining the efficacy of psychostimulant medications in the treatment of children with ADHD. Trials were excluded if (1) they required additional psychiatric or medical comorbidity in addition to ADHD, (2) they involved fewer than 20 subjects (parallel group trials), or (3) children received psychostimulant medication for less than 1 week. Data Extraction: A fixed-effects meta-analysis was used to examine the risk ratio of irritability reported as a side effect in children treated with psychostimulants compared to placebo. Stratified subgroup analysis and meta-regression were used to examine the effects of stimulant type, dosage, duration of use, and trial design on the measured risk of irritability. Results: From 92 potentially eligible trials, the meta-analysis identified 32 trials involving 3,664 children with ADHD that reported data on irritability as a side effect. The relative risk of irritability significantly differed between psychostimulant classes (test for subgroup differences.2 1 = 7.6, P =.006). Methylphenidate derivatives were associated with a significantly decreased risk of irritability compared to placebo (risk ratio [RR] = 0.89 [95% CI, 0.82 to 0.96], z = -2.87, P =.004, k = 32, I2 = 50%), whereas amphetamine derivatives were associated with a significantly increased risk of irritability (RR = 2.90 [95% CI, 1.26 to 6.71], z = 2.5, P =.01, k = 5, I2 = 0%). Conclusions: This meta-analysis suggests an increased risk of irritability may be confined to amphetamine-derived psychostimulants. Future meta-analyses examining the effects of amphetamine and methylphenidate derivatives on irritability as a continuous measure, as well as head-to-head trials between methylphenidate and amphetamine derivatives examining effects on irritability, will be important to replicate the findings of this meta-analysis. (C) Copyright 2017 Physicians Postgraduate Press, Inc.
- Clinical Efficacy of a New Automated Hemoencefalographic Neurofeedback Protocol(2012) DIAS, Alvaro Machado; DEUSEN, Adrian Machado Van; ODA, Eduardo; BONFIM, Mariana RodriguesAmong the ongoing attempts to enhance cognitive performance, an emergent and yet underrepresented venue is brought by hemoencefalographic neurofeedback (HEG). This paper presents three related advances in HEG neurofeedback for cognitive enhancement: a) a new HEG protocol for cognitive enhancement, as well as b) the results of independent measures of biological efficacy (EEG brain maps) extracted in three phases, during a one year follow up case study; c) the results of the first controlled clinical trial of HEG, designed to assess the efficacy of the technique for cognitive enhancement of an adult and neurologically intact population. The new protocol was developed in the environment of a software that organizes digital signal algorithms in a flowchart format. Brain maps were produced through 10 brain recordings. The clinical trial used a working memory test as its independent measure of achievement. The main conclusion of this study is that the technique appears to be clinically promising. Approaches to cognitive performance from a metabolic viewpoint should be explored further. However, it is particularly important to note that, to our knowledge, this is the world's first controlled clinical study on the matter and it is still early for an ultimate evaluation of the technique.