ANA GABRIELA HOUNIE
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
conferenceObject Does Inflammation Play a Role in Obsessive-Compulsive Disorder?(2013) SILVERMAN, Marni; CASSAB, Raony; MUNIZ, Renan; SHAVITT, Roseli G.; TOLEDO, Maria Cecilia; CAPPI, Carolina; THAYER, Julian; MATHIS, Maria Alice de; DINIZ, Juliana B.; HOEXTER, Marcelo Q.; D'ALCANTE, Carina C.; BORCATO, Sonia; HOUNIE, Ana G.; WHITFIELD, Jessie; BELYAVSKAYA, Elena; STERNBERG, Esther; MIGUEL, Euripedes; MARQUES, Andrea H.- Whole-exome Sequencing in Obsessive-compulsive Disorder Identifies Rare Mutations and Immunological Pathways(2014) CAPPI, Carolina; BRENTANI, Helena; LIMA, Leandro; SANDERS, Stephan J.; DINIZ, Juliana; WALKER, Michael; REIS, Viviane N. S.; HOUNIE, Ana G.; MARIANI, Daniel; OKI, Fabio H.; SHAVITT, Roseli G.; PAULS, David L.; MIGUEL, Euripedes C.; FERNANDEZ, Thomas V.
- Comorbid major depression in obsessive-compulsive disorder patients(2011) QUARANTINI, Lucas C.; TORRES, Albina Rodrigues; SAMPAIO, Aline S.; FOSSALUZA, Victor; MATHIS, Maria Alice de; ROSARIO, Maria Conceicao do; FONTENELLE, Leonardo F.; FERRAO, Ygor A.; CORDIOLI, Aristides Volpato; PETRIBU, Katia; HOUNIE, Ana G.; MIGUEL, Euripedes C.; SHAVITT, Roseli G.; KOENEN, Karestan C.Although major depressive disorder (MDD) has been consistently considered the most frequent complication of obsessive-compulsive disorder (OCD), little is known about the clinical characteristics of patients with both disorders. This study assessed 815 Brazilian OCD patients using a comprehensive psychiatric evaluation. Clinical and demographic variables, including OCD symptom dimensions, were compared among OCD patients with and without MDD. Our findings showed that prevalence rates of current MDD (32%) and lifetime MDD (67.5%) were similar for both sexes in this study. In addition, patients with comorbid MDD had higher severity scores of OCD symptoms. There was no preferential association of MDD with any particular OCD symptom dimension. This study supports the notion that depressed OCD patients present more severe general psychopathology.
- Clinical predictors of quality of life in a large sample of adult obsessive-compulsive disorder outpatients(2018) VELLOSO, Patricia; PICCINATO, Cinthia; FERRAO, Ygor; PERIN, Eduardo Aliende; CESAR, Raony; FONTENELLE, Leonardo F.; HOUNIE, Ana G.; ROSARIO, Maria Conceicao doBackground: OCD causes impairment in different areas of the patients' quality of life (QoL), such as sociability, family relationships, and occupational performance. The literature has emphasized the relevance of assessing QoL as a critical outcome in mental health studies. Aims: The aim of this study was to investigate sociodemographic and clinical predictors of QoL, including treatment response, in a large sample of OCD subjects. Procedures: 575 adult OCD outpatients were interviewed as part of the Brazilian OCD Consortium (CTOC). A smaller number of subjects (N = 143) participated on a clinical trial conducted by one of the CTOC sites. Results: OCD patients were more impaired in their QoL when compared to the Brazilian normative data. Obsessive-compulsive symptoms (OCS) severity had significant correlations with all Medical Outcome Short Form questionnaire (SF-36) domains. Different OCS dimensions had specific correlations with each SF-36 domain. OCS, depression and anxiety severity significantly increased the impairment risk for the SF-36 domains. Suicidality increased the relative risks for impairment in the Role-Functioning and the Vitality domains by 51% and 17%, respectively. There was a significant improvement in some SF-36 dimensions after treatment. Conclusions: QoL domains are highly compromised in OCD patients. Each SF-36 domain had distinct associations with sociodemographic and clinical variables, including OCS dimensions, suicidality and treatment response. These findings emphasize the OCD heterogeneity and the need for including QoL assessment in clinical practice and research studies.
- Trajectory in obsessive-compulsive disorder comorbidities(2013) MATHIS, Maria Alice de; DINIZ, Juliana B.; HOUNIE, Ana G.; SHAVITT, Roseli G.; FOSSALUZA, Victor; FERRAO, Ygor; LECKMAN, James F.; PEREIRA, Carlos de Braganca; ROSARIO, Maria Conceicao do; MIGUEL, Euripedes C.The main goal of this study is to contribute to the understanding of the trajectory of comorbid disorders associated with obsessive-compulsive disorder (OCD) according to the first manifested psychiatric disorder and its impact in the clinical course of OCD and subsequent psychiatric comorbidities. One thousand and one OCD patients were evaluated at a single time point. Standardized instruments were used to determine the current and lifetime psychiatric diagnoses (Structured Clinical Interview for DSM-IV Axis I and for impulse-control disorders) as well as to establish current obsessive-compulsive, depressive and anxiety symptom severity (Yale-Brown Obsessive-Compulsive Scale; Dimensional Yale-Brown Obsessive-Compulsive Scale, Beck Depression and Anxiety Inventories and the OCD Natural History Questionnaire). To analyze the distribution of comorbidities according to age at onset Bayesian approach was used. Five hundred eight patients had the first OC symptom onset till the age of 10 years old. The first comorbidity to appear in the majority of the sample was separation anxiety disorder (17.5%, n=175), followed by ADHD (5.0%, n=50) and tic disorders (4.4%, n=44). OCD patients that presented with separation anxiety disorder as first diagnosis had higher lifetime frequency of post-traumatic stress disorder (p=0.003), higher scores in the Sexual/Religious dimension (p=0.04), Beck Anxiety (p<0.001) and Depression (p=0.005) Inventories. OCD patients that initially presented with ADHD had higher lifetime frequencies of substance abuse and dependence (p<0.001) and worsening OCD course (p=0.03). OCD patients that presented with tic disorders as first diagnosis had higher lifetime frequencies of OC spectrum disorders (p=0.03). OCD is a heterogeneous disorder and that the presence of specific comorbid diagnoses that predate the onset of OCD may influence its clinical presentation and course over the lifetime.
- Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD(2015) YU, Dongmei; MATHEWS, Carol A.; SCHARF, Jeremiah M.; NEALE, Benjamin M.; DAVIS, Lea K.; GAMAZON, Eric R.; DERKS, Eske M.; EVANS, Patrick; EDLUND, Christopher K.; CRANE, Jacquelyn; OSIECKI, Lisa; RENNER, Tobias; REUS, Victor I.; RICHTER, Margaret A.; RIDDLE, Mark A.; ROBERTSON, Mary M.; ROMERO, Roxana; ROSARIO, Maria C.; ROSENBERG, David; RUHRMANN, Stephan; SABATTI, Chiara; GALLAGHER, Patience; SALVI, Erika; SAMPAIO, Aline S.; SAMUELS, Jack; SANDOR, Paul; SERVICE, Susan K.; SHEPPARD, Brooke; SINGER, Harvey S.; SMIT, Jan H.; STEIN, Dan J.; STRENGMAN, Eric; GERBER, Gloria; TISCHFIELD, Jay A.; TURIEL, Maurizio; DUARTE, Ana V. Valencia; VALLADA, Homero; VEENSTRA-VANDERWEELE, Jeremy; WALITZA, Susanne; WANG, Ying; WEALE, Mike; WEISS, Robert; WENDLAND, Jens R.; HADDAD, Stephen; WESTENBERG, Herman G. M.; SHUGART, Yin Yao; HOUNIE, Ana G.; MIGUEL, Euripedes C.; NICOLINI, Humberto; WAGNER, Michael; RUIZ-LINARES, Andres; CATH, Danielle C.; MCMAHON, William; POSTHUMA, Danielle; ILLMANN, Cornelia; OOSTRA, Ben A.; NESTADT, Gerald; ROUTEAU, Guy A.; PURCELL, Shaun; JENIKE, Michael A.; HEUTINK, Peter; HANNA, Gregory L.; CONTI, David V.; ARNOLD, Paul D.; FREIMER, Nelson B.; MCGRATH, Lauren M.; STEWART, Evelyn; KNOWLES, James A.; COX, Nancy J.; PAULS, David L.; MAYERFELD, Catherine; AREPALLI, Sampath; BARLASSINA, Cristina; BARR, Cathy L.; BELLODI, Laura; BENARROCH, Fortu; BERRIO, Gabriel Bedoya; BIENVENU, O. Joseph; BLACK, Donald W.; BLOCH, Michael H.; BRENTANI, Helena; BRUUN, Ruth D.; BUDMAN, Cathy L.; CAMARENA, Beatriz; CAMPBELL, Desmond D.; CAPPI, Carolina; SILGADO, Julio C. Cardona; CAVALLINI, Maria C.; CHAVIRA, Denise A.; CHOUINARD, Sylvain; COOK, Edwin H.; COOKSON, M. R.; CORIC, Vladimir; CULLEN, Bernadette; CUSI, Daniete; DELORME, Richard; DENYS, Damiaan; DION, Yves; EAPEN, Valsama; EGBERTS, Karin; FALKAI, Peter; FERNANDEZ, Thomas; FOURNIER, Eduardo; GARRIDO, Helena; GELLER, Daniel; GILBERT, Donald L.; GIRARD, Simon L.; GRABE, Hans J.; GRADOS, Marco A.; GREENBERG, Benjamin D.; GROSS-TSUR, Varda; GRUENBLATT, Edna; HARDY, John; HEIMAN, Gary A.; HEMMINGS, Sian M. J.; HERRERA, Luis D.; HEZEL, Dianne M.; HOEKSTRA, Pieter J.; JANKOVIC, Joseph; KENNEDY, James L.; KING, Robert A.; KONKASHBAEV, Anuar I.; KREMEYER, Barbara; KURLAN, Roger; LANZAGORTA, Nuria; LEBOYER, Marion; LECKMAN, James F.; LENNERTZ, Leonhard; LIU, Chunyu; LOCHNER, Christine; LOWE, Thomas L.; LUPOLI, Sara; MACCIARDI, Fabio; MAIER, Wolfgang; MANUNTA, Paolo; MARCONI, Maurizio; MCCRACKEN, James T.; RESTREPO, Sandra C. Mesa; MOESSNER, Rainald; MOORJANI, Priya; MORGAN, Jubel; MULLER, Heike; MURPHY, Dennis L.; NAARDEN, Allan L.; NURMI, Erika; OCHOA, William Cornejo; OPHOFF, Roel A.; PAKSTIS, Andrew J.; PATO, Michele T.; PATO, Carlo N.; PIACENTINI, John; PITTENGER, Christopher; POLLAK, Yehuda; RAUCH, Scott L.Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex disorders remains elusive. The authors report a combined genome-wide association study (GWAS) of Tourette's syndrome and OCD. Method: The authors conducted a GWAS in 2,723 cases (1,310 with OCD, 834 with Tourette's syndrome, 579 with OCD plus Tourette's syndrome/chronic tics), 5,667 ancestry-matched controls, and 290 OCD parent-child trios. GWAS summary statistics were examined for enrichment of functional variants associated with gene expression levels in brain regions. Polygenic score analyses were conducted to investigate the genetic architecture within and across the two disorders. Results: Although no individual single-nucleotide polymorphisms (SNPs) achieved genome-wide significance, the GWAS signals were enriched for SNPs strongly associated with variations in brain gene expression levels (expression quantitative loci, or eQTLs), suggesting the presence of true functional variants that contribute to risk of these disorders Polygenic score analyses identified a significant polygenic component for OCD (p=2x10(-4)), predicting 3.2% of the phenotypic variance in an independent data set. In contrast, Tourette's syndrome had a smaller, nonsignificant polygenic component, predicting only 0.6% of the phenotypic variance (p=0.06). No significant polygenic signal was detected across the two disorders, although the sample is likely underpowered to detect a modest shared signal. Furthermore, the OCD polygenic signal was significantly attenuated when cases with both OCD and co-occurring Tourette's syndrome/chronic tics were included in the analysis (p=0.01). Conclusions: Previous work has shown that Tourette's syndrome and OCD have some degree of shared genetic variation. However, the data from this study suggest that there are also distinct components to the genetic architectures of these two disorders. Furthermore, OCD with co-occurring burette's syndrome/chronic tics may have different underlying genetic susceptibility compared with OCD alone.
- Sex differences in the genetic architecture of obsessive-compulsive disorder(2019) KHRAMTSOVA, Ekaterina A.; HELDMAN, Raphael; DERKS, Eske M.; YU, Dongmei; DAVIS, Lea K.; STRANGER, Barbara E.; ARNOLD, Paul D.; ASKLAND, Kathleen D.; BARLASSINA, Cristina; BELLODI, Laura; BIENVENU, O. J.; BLACK, Donald; BLOCH, Michael; BRENTANI, Helena; BURTON, Christie L.; CAMARENA, Beatriz; CAPPI, Carolina; CATH, Danielle; CAVALLINI, Maria; CONTI, David; COOK, Edwin; CORIC, Vladimir; CULLEN, Bernadette A.; CUSI, Danielle; DAVIS, Lea K.; DELORME, Richard; DENYS, Damiaan; DERKS, Eske; EAPEN, Valsamma; EDLUND, Christopher; ERDMAN, Lauren; FALKAI, Peter; FIGEE, Martijn; FYER, Abigail J.; GELLER, Daniel A.; GOES, Fernando S.; GRABE, Hans; GRADOS, Marcos A.; GREENBERG, Benjamin D.; GRUNBLATT, Edna; GUO, Wei; HANNA, Gregory L.; HEMMINGS, Sian; HOUNIE, Ana G.; JENICKE, Michael; KEENAN, Clare; KENNEDY, James; KHRAMTSOVA, Ekaterina A.; KONKASHBAEV, Anuar; KNOWLES, James A.; KRASNOW, Janice; LANGE, Cristophe; LANZAGORTA, Nuria; LEBOYER, Marion; LENNERTZ, Leonhard; LI, Bingbin; LIANG, K-Y; LOCHNER, Christine; MACCIARDI, Fabio; MAHER, Brion; MAIER, Wolfgang; MARCONI, Maurizio; MATHEWS, Carol A.; MATTHESIEN, Manuel; MCCRACKEN, James T.; MCLAUGHLIN, Nicole C.; MIGUEL, Euripedes C.; MOESSNER, Rainald; MURPHY, Dennis L.; NEALE, Benjamin; NESTADT, Gerald; NESTADT, Paul; NICOLINI, Humberto; NURMI, Ericka; OSIECKI, Lisa; PATO, Carlos; PATO, Michelle; PAULS, David L.; PIACENTINI, John; POSTHUMA, Danielle; PULVER, Ann E.; QIN, H-D; RASMUSSEN, Steven A.; RAUCH, Scott; RICHTER, Margaret A.; RIDDLE, Mark A.; RIPKE, Stephan; RUHRMANN, Stephan; SAMPAIO, Aline S.; SAMUELS, Jack F.; SCHARF, Jeremiah M.; SHUGART, Yin Yao; SMIT, Jan; STEIN, Daniel; STEWART, S. Evelyn; TURIEL, Maurizio; VALLADA, Homero; VEENSTRA-VANDERWEELE, Jeremy; WAGNER, Michael; WALITZA, Susanne; WANG, Y.; WENDLAND, Jens; VULINK, Nienke; YU, Dongmei; ZAI, GwynethObsessive-compulsive disorder (OCD) is a highly heritable complex phenotype that demonstrates sex differences in age of onset and clinical presentation, suggesting a possible sex difference in underlying genetic architecture. We present the first genome-wide characterization of the sex-specific genetic architecture of OCD, utilizing the largest set of OCD cases and controls available from the Psychiatric Genomics Consortium. We assessed evidence for several mechanisms that may contribute to sex differences including a sex-dependent liability threshold, the presence of individual sex-specific risk variants on the autosomes and the X chromosome, and sex-specific pleiotropic effects. Furthermore, we tested the hypothesis that genetic heterogeneity between the sexes may obscure associations in a sex-combined genome-wide association study. We observed a strong genetic correlation between male and female OCD and no evidence for a sex-dependent liability threshold model, suggesting that sex-combined analysis does not suffer from widespread loss of power because of genetic heterogeneity between the sexes. While we did not detect any significant sex-specific genome-wide single nucleotide polymorphisms (SNP) associations, we did identify two significant gene-based associations in females: GRID2 and GRP135, which showed no association in males. We observed that the SNPs with sexually differentiated effects showed an enrichment of regulatory variants influencing expression of genes in brain and immune tissues. These findings suggest that future studies with larger sample sizes hold great promise for the identification of sex-specific genetic risk factors for OCD.
- Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study(2014) MCGRATH, Lauren M.; YU, Dongmei; MARSHALL, Christian; DAVIS, Lea K.; THIRUVAHINDRAPURAM, Bhooma; LI, Bingbin; CAPPI, Carolina; GERBER, Gloria; WOLF, Aaron; SCHROEDER, Frederick A.; OSIECKI, Lisa; O'DUSHLAINE, Colm; KIRBY, Andrew; ILLMANN, Cornelia; HADDAD, Stephen; GALLAGHER, Patience; FAGERNESS, Jesen A.; BARR, Cathy L.; BELLODI, Laura; BENARROCH, Fortu; BIENVENU, O. Joseph; BLACK, Donald W.; BLOCH, Michael H.; BRUUN, Ruth D.; BUDMAN, Cathy L.; CAMARENA, Beatriz; CATH, Danielle C.; CAVALLINI, Maria C.; CHOUINARD, Sylvain; CORIC, Vladimir; CULLEN, Bernadette; DELORME, Richard; DENYS, Damiaan; DERKS, Eske M.; DION, Yves; ROSARIO, Maria C.; EAPEN, Valsama; EVANS, Patrick; FALKAI, Peter; FERNANDEZ, Thomas V.; GARRIDO, Helena; GELLER, Daniel; GRABE, Hans J.; GRADOS, Marco A.; GREENBERG, Benjamin D.; GROSS-TSUR, Varda; GRUENBLATT, Edna; HEIMAN, Gary A.; HEMMINGS, Sian M. J.; HERRERA, Luis D.; HOUNIE, Ana G.; JANKOVIC, Joseph; KENNEDY, James L.; KING, Robert A.; KURLAN, Roger; LANZAGORTA, Nuria; LEBOYER, Marion; LECKMAN, James F.; LENNERTZ, Leonhard; LOCHNER, Christine; LOWE, Thomas L.; LYON, Gholson J.; MACCIARDI, Fabio; MAIER, Wolfgang; MCCRACKEN, James T.; MCMAHON, William; MURPHY, Dennis L.; NAARDEN, Allan L.; NEALE, Benjamin M.; NURMI, Erika; PAKSTIS, Andrew J.; PATO, Michele T.; PATO, Carlos N.; PIACENTINI, John; PITTENGER, Christopher; POLLAK, Yehuda; REUS, Victor I.; RICHTER, Margaret A.; RIDDLE, Mark; ROBERTSON, Mary M.; ROSENBERG, David; ROULEAU, Guy A.; RUHRMANN, Stephan; SAMPAIO, Aline S.; SAMUELS, Jack; SANDOR, Paul; SHEPPARD, Brooke; SINGER, Harvey S.; SMIT, Jan H.; STEIN, Dan J.; TISCHRIELD, Jay A.; VALLADA, Homero; VEENSTRA-VANDERWEELE, Jeremy; WALITZA, Susanne; WANG, Ying; WENDFAND, Jens R.; SHUGART, Yin Yao; MIGUEL, Euripedes C.; NICOLINI, Humberto; OOSTRA, Ben A.; MOESSNER, Rainald; WAGNER, Michael; RUIZ-LINARES, Andres; HEUTINK, Peter; NESTADT, Gerald; FREIMER, Nelson; PETRYSHEN, Tracey; POSTHUMA, Danielle; JENIKE, Michael A.; COX, Nancy J.; HANNA, Gregory L.; BRENTANI, Helena; SCHERER, Stephen W.; ARNOLD, Paul D.; STEWART, S. Evelyn; MATHEWS, Carol A.; KNOWLES, James A.; COOK, Edwin H.; PAULS, David L.; WANG, Kai; SCHARF, Jeremiah M.Objective: Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (<1%) copy number variants (CNVs) in OCD and the largest genome-wide CNV analysis in TS to date. Method: The primary analyses used a cross-disorder design for 2,699 case patients (1,613 ascertained for OCD, 1,086 ascertained for TS) and 1,789 controls. Parental data facilitated a de novo analysis in 348 OCD trios. Results: Although no global CNV burden was detected in the cross-disorder analysis or in secondary, disease-specific analyses, there was a 3.3-fold increased burden of large deletions previously associated with other neurodevelopmental disorders (p = .09). Half of these neurodevelopmental deletions were located in a single locus, 16p13.11 (5 case patient deletions: 0 control deletions, p = .08 in the current study, p = .025 compared to published controls). Three 16p13.11 deletions were confirmed de novo, providing further support for the etiological significance of this region. The overall OCD de novo rate was 1.4%, which is intermediate between published rates in controls (0.7%) and in individuals with autism or schizophrenia (2-4%). Conclusion: Several converging lines of evidence implicate 16p13.11 deletions in OCD, with weaker evidence for a role in TS. The trend toward increased overall neurodevelopmental CNV burden in TS and OCD suggests that deletions previously associated with other neurodevelopmental disorders may also contribute to these phenotypes.