HELENA HIDEKO SEGUCHI KAZIYAMA

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Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina

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  • article 5 Citação(ões) na Scopus
    Sifting the wheat from the chaff? Evidence for the existence of an asymmetric fibromyalgia phenotype
    (2020) KAZIYAMA, Helena H.; BARBOUR, Julio; GALHARDONI, Ricardo; SILVA, Valquiria Aparecida da; SIQUEIRA, Silvia R. D. Tesseroli de; LISTIK, Clarice; SANTOS, Gabriel Jose dos; YENG, Lin T.; MARCOLIN, Marco Antonio; RAICHER, Irina; TEIXEIRA, Manoel J.; ANDRADE, Daniel Ciampi de
    Background The different phenotypic presentations of fibromyalgia (FM) have been infrequently studied and may have diagnostic and therapeutic implications. The aim of this study was to explore differences between FM patients with classical symmetric (s-FM) presentation and FM patients with marked asymmetric (a-FM) pain. Methods We performed two consecutive cross-sectional studies on FM patients and matched healthy volunteers (HV). FM patients were divided into a-FM (and s-FM groups according to their score of pain intensity on each body side; patients with a difference of >= 40 mm in VAS between left and right sides were classified as a-FM, otherwise classified as s-FM. Participants (FM = 32; HV = 31) were assessed for clinical, cortical excitability (CE), quantitative sensory testing (QST; study 1), and intraepidermal nerve fibre density (IENFD) determinations (study 2). Results While pain intensity did not significantly differ between s-FM and a-FM patients, pain interference in daily activities was significantly higher in the a-FM as compared to the s-FM group (54.7 +/- 8.9 and 37.6 +/- 13.5;p < .0001). PPT was significantly lower in the more painful side of a-FM as compared to the HV (27.7 +/- 7.9 and 49.9 +/- 13.0;p < .0001), while PPT in the less painful side of a-FM was significantly higher than PPT values in the s-FM (35.8 +/- 8.3 and 27.7 +/- 5.5;p = .031). S-FM and a-FM had significantly abnormal intracortical inhibition values on CE measurements compared to HV. There were no significant differences in IENFD between groups. Conclusions Within the current FM criteria, there exist different phenotypes with clinical, psychophysics, and neurophysiological findings that are not related to peripheral IENFD abnormalities. Significance Current fibromyalgia criteria may contain different phenotypes of fibromyalgia based on the lateralization of pain.
  • article 26 Citação(ões) na Scopus
    The association of major depressive episode and personality traits in patients with fibromyalgia
    (2011) SANTOS, Danyella de Melo; LAGE, Lais Verderame; JABUR, Eleonora Kehl; KAZIYAMA, Helena Hideko Seguchi; IOSIFESCU, Dan V.; LUCIA, Mara Cristina Souza de; FRAGUAS, Renerio
    INTRODUCTION: Personality traits have been associated with primary depression. However, it is not known whether this association takes place in the case of depression comorbid with fibromyalgia. OBJECTIVE: The authors investigated the association between a current major depressive episode and temperament traits (e. g., harm avoidance). METHOD: A sample of 69 adult female patients with fibromyalgia was assessed with the Temperament and Character Inventory. Psychiatric diagnoses were assessed with the Mini-International Neuropsychiatric Interview severity of depressive symptomatology with the Beck Depression Inventory, and anxiety symptomatology with the IDATE-state and pain intensity with a visual analog scale. RESULTS: A current major depressive episode was diagnosed in 28 (40.5%) of the patients. They presented higher levels of harm avoidance and lower levels of cooperativeness and self-directedness compared with non-depressed patients, which is consistent with the Temperament and Character Inventory profile of subjects with primary depression. However, in contrast to previous results in primary depression, no association between a major depressive episode and self-transcendence was found. CONCLUSIONS: The results highlight specific features of depression in fibromyalgia subjects and may prove important for enhancing the diagnosis and prognosis of depression in fibromyalgia patients.
  • article 8 Citação(ões) na Scopus
    Analysis of Epigenetic Age Predictors in Pain-Related Conditions
    (2020) KWIATKOWSKA, Katarzyna Malgorzata; BACALINI, Maria Giulia; SALA, Claudia; KAZIYAMA, Helena; ANDRADE, Daniel Ciampi de; TERLIZZI, Rossana; GIANNINI, Giulia; CEVOLI, Sabina; PIERANGELI, Giulia; CORTELLI, Pietro; GARAGNANI, Paolo; PIRAZZINI, Chiara
    Chronic pain prevalence is high worldwide and increases at older ages. Signs of premature aging have been associated with chronic pain, but few studies have investigated aging biomarkers in pain-related conditions. A set of DNA methylation (DNAm)-based estimates of age, called ""epigenetic clocks,"" has been proposed as biological measures of age-related adverse processes, morbidity, and mortality. The aim of this study is to assess if different pain-related phenotypes show alterations in DNAm age. In our analysis, we considered three cohorts for which whole-blood DNAm data were available: heat pain sensitivity (HPS), including 20 monozygotic twin pairs discordant for heat pain temperature threshold; fibromyalgia (FM), including 24 cases and 20 controls; and headache, including 22 chronic migraine and medication overuse headache patients (MOH), 18 episodic migraineurs (EM), and 13 healthy subjects. We used the Horvath's epigenetic age calculator to obtain DNAm-based estimates of epigenetic age, telomere length, levels of 7 proteins in plasma, number of smoked packs of cigarettes per year, and blood cell counts. We did not find differences in epigenetic age acceleration, calculated using five different epigenetic clocks, between subjects discordant for pain-related phenotypes. Twins with high HPS had increased CD8+ T cell counts (nominalp= 0.028). HPS thresholds were negatively associated with estimated levels of GDF15 (nominalp= 0.008). FM patients showed decreased naive CD4+ T cell counts compared with controls (nominalp= 0.015). The severity of FM manifestations expressed through various evaluation tests was associated with decreased levels of leptin, shorter length of telomeres, and reduced CD8+ T and natural killer cell counts (nominalp< 0.05), while the duration of painful symptoms was positively associated with telomere length (nominalp= 0.034). No differences in DNAm-based estimates were detected for MOH or EM compared with controls. In summary, our study suggests that HPS, FM, and MOH/EM do not show signs of epigenetic age acceleration in whole blood, while HPS and FM are associated with DNAm-based estimates of immunological parameters, plasma proteins, and telomere length. Future studies should extend these observations in larger cohorts.
  • article 12 Citação(ões) na Scopus
    Depression, sexuality and fibromyalgia syndrome: clinical findings and correlation to hematological parameters
    (2016) ALVES, Bruna; ZAKKA, Telma M.; TEIXEIRA, Manoel J.; KAZIYAMA, Helena H.; SIQUEIRA, Jose T. T.; SIQUEIRA, Silvia R. D. T.
    Fibromyalgia (FM) is characterized by chronic pain and comorbidities. Objective: To investigate sexuality and depression in women with FM compared with controls and to correlate the findings with hematological parameters. Methods: 33 women with FM and 19 healthy women were included and evaluated with the following instruments: Female Sexual Function Index, Beck Inventory, Visual Analogue Scale, medical history and laboratory exams. Results: The prevalence of sexual dysfunction (P = 0.007) and depression (P < 0.001) were higher in the study group than in the control group; they were positively correlated (P = 0.023). The study group showed lower serum concentrations of testosterone, free T4, antinuclear factor, and lower blood hemoglobin and hematocrit. Conclusions: FM was associated with high scores of sexual dysfunction and depression, and there were correlations with hematological parameters. We suggest the involvement of immune-inflammatory mediators and FM, which need further investigation to understand their role in FM syndrome and its comorbidities.
  • article 108 Citação(ões) na Scopus
    Repetitive Transcranial Magnetic Stimulation in Chronic Pain: A Review of the Literature
    (2015) GALHARDONI, Ricardo; CORREIA, Guilherme S.; ARAUJO, Haniel; YENG, Lin T.; FERNANDES, Diego T.; KAZIYAMA, Helena H.; MARCOLIN, Marco A.; BOUHASSIRA, Didier; TEIXEIRA, Manoel Jacobsen; ANDRADE, Daniel Ciampi de
    Objective: To review the literature on the analgesic effects of repetitive transcranial magnetic stimulation (rTMS) in chronic pain according to different pain syndromes and stimulation parameters. Data Sources: Publications on rTMS and chronic pain were searched in PubMed and Google Scholar using the following key words: chronic pain, analgesia, transcranial magnetic stimulation, neuropathic pain, fibromyalgia, and complex regional pain syndrome. Study Selection: This review only included double-blind, controlled studies with >10 participants in each arm that were published from 1996 to 2014 and written in English. Studies with relevant information for the understanding of the effects of rTMS were also cited. Data Extraction: The following data were retained: type of pain syndrome, type of study, coil type, target, stimulation intensity, frequency, number of pulses, orientation of induced current, number of session, and a brief summary of intervention outcomes. Data Synthesis: A total of 33 randomized trials were found. Many studies reported significant pain relief by rTMS, especially high-frequency stimulation over the primary motor cortex performed in consecutive treatment sessions. Pain relief was frequently >30% compared with control treatment. Neuropathic pain, fibromyalgia, and complex regional pain syndrome were the pain syndromes more frequently studied. However, among all published studies, only a few performed repetitive sessions of rTMS. Conclusions: rTMS has potential utility in the management of chronic pain; however, studies using maintenance sessions of rTMS and assessing the effects of rTMS on the different aspects of chronic pain are needed to provide a more solid basis for its clinical application for pain relief. (C) 2015 by the American Congress of Rehabilitation Medicine
  • bookPart
    OPÇÕES NO TRATAMENTO MEDICAMENTOSO DA DOR CRÔNICA
    (2016) ANDRADE, Daniel Ciampi de; VALéRIO, Fernanda; DOURADO, Luiz Henrique; YENG, Lin Tchia; KAZIYAMA, Helena H. S.; TEIXEIRA, Manoel Jacobsen
  • bookPart
    Avaliação Funcional do Doente com Dor
    (2019) YENG, Lin Tchia; KOBAYASHI, Ricardo; KOBAYASHI, Carolina Besser Cozac; KAZIYAMA, Helena Hideko Seguchi; LODUCA, Adrianna; TEIXEIRA, Manoel Jacobsen
  • bookPart
    Dor nos Membros Inferiores
    (2019) STUMP, Patrick; HERNANDEZ, Arnaldo José; ARAUJO, Joaci Oliveira de; KAZIYAMA, Helena Hideko Seguchi
  • article 4 Citação(ões) na Scopus
    Relationship between the coronavirus disease 2019 pandemic and immobilization syndrome
    (2021) PLAPLER, Perola Grinberg; SOUZA, Daniel Rubio de; KAZIYAMA, Helena Hideko Seguchi; BATTISTELLA, Linamara Rizzo; BARROS-FILHO, Tarcisio Eloy Pessoa de
  • article 10 Citação(ões) na Scopus
    Dry needling has lasting analgesic effect in shoulder pain: a double-blind, sham-controlled trial
    (2021) PAI, Marcus Yu Bin; TOMA, Juliana Takiguti; KAZIYAMA, Helena Hideko Seguchi; LISTIK, Clarice; GALHARDONI, Ricardo; YENG, Lin Tchia; TEIXEIRA, Manoel Jacobsen; ANDRADE, Daniel Ciampi de
    Introduction: Myofascial pain syndrome (MPS) affects most patients with chronic shoulder pain. Dry needling (DN) is a common treatment for MPS, but its temporal pattern and sensory effects remain unknown. Objectives: We evaluated in a randomized, sham-controlled study the pattern of analgesic efficacy and local sensory changes of a single session of DN for MPS in patients with chronic shoulder pain. Methods: Patients with chronic shoulder pain were randomized into active (n = 20) or sham (n = 21) groups. A single DN was performed by a researcher blinded to group assignment and pain outcomes. Pain intensity was assessed by the numeric rating score, and sensory thresholds were evaluated with a quantitative sensory testing protocol, including the area of tactile sensory abnormalities 7 days before needling, right before, and 7 days after the intervention. Results: Dry needling led to significant larger pain intensity reduction (from 6.30 +/- 2.05 to 2.40 +/- 2.45 in the active group; P = 0.02, effect size = -1.3 (95% CI [-2.0 to -0.68]); (number necessary to treat = 2.1). Pain reduction scores were significantly different on the second day after needling and persisted so until the seventh day and were accompanied by improvement in other dimensions of pain and a decrease in the area of mechanical hyperalgesia in the active DN group alone (P < 0.05). Conclusion: Active trigger points DN provided analgesic effects compared with sham and decreased the area of local mechanical hyperalgesia. These findings have practical clinical implications and may provide mechanistic insights behind MPS.