BRUNO MENDONCA PROTASIO DA SILVA
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conferenceObject Safety and efficacy of adjuvant modified FLOX for patients (pts) with stage III colorectal cancer (CRC) treated in the community.(2015) PROTASIO, Bruno Mendonca; MATUTINO, Adriana Reis Brandao; LAGE, Liana Valente; SANTANA, Iuri Amorim De; RAMOS, Ricardo Emanuel De Oliveira; CAIRES-LIMA, Rafael; CAIRES, Inacelli Queiroz De Souza; RIECHELMANN, Rachel Pimenta; SARAGIOTTO, Daniel Fernandes; SABBAGA, Jorge; HOFF, Paulo MarceloconferenceObject Cancer patients with ECOG-PS higher than 1: Who are those who benefit of palliative chemotherapy?(2013) CAIRES-LIMA, Rafael; PROTASIO, Bruno Mendonca; CAIRES, Inacelli Queiroz de Souza; ROCHA, Lucila Soares Da Silva; OLIVEIRA, Julia Andrade De; GUERRA, Raquel Bezerra; MAK, Milena Perez; HOFF, Paulo M.; CASTRO, GilbertoconferenceObject Prophylactic anticonvulsants in patients (pts) with primary brain tumor (PBT): Have we really agreed to a consensus?(2013) OLIVEIRA, Julia Andrade de; SANTANA, Iuri Amorim De; CAIRES, Inacelli Queiroz de Souza; CAIRES-LIMA, Rafael; MIRANDA, Vanessa Costa; PROTASIO, Bruno Mendonca; ROCHA, Lucila Soares Da Silva; BRAGA, Henrique Faria; MENCARINI, Ana Cristina Malacarne; TEIXEIRA, Manoel Jacobsen; CASTRO, Luiz Henrique Martins; FEHER, OlavoconferenceObject EGFR GENOTYPING AND EPIDEMIOLOGY, CLINICAL AND PATHOLOGICAL FEATURES IN 191 PATIENTS WITH METASTATIC PULMONARY ADENOCARCINOMA IN SAO PAULO - BRAZIL.(2013) CASTRO JR., Gilberto; TAKAHASHI, Tiago K.; CAIRES-LIMA, Rafael; PROTASIO, Bruno M.; MAIA, Manuel C. D. F.; SOARES, Ibere C.; ROITBERG, Felipe S. R.; MARINI, Andrea M.; MARTINS, Renata E.; TAKAGAKI, Teresa Y.; ARAUJO, Pedro H. X. N.; TERRA, Ricardo M.; SHIANG, Christina; SIQUEIRA, Sheila A. C.; MELLO, Evandro S.; ALVES, Venancio A.; HOFF, Paulo M.conferenceObject Prognostic impact of primary tumor sidedness in stage III colorectal cancer(2023) PROTASIO, Bruno Mendonca; CASTRIA, Tiago Biachi de; SARAGIOTTO, Daniel Fernandes; NATALINO, Renato Jose Mendonca; MANGONE, Flavia Regina Rotea; SABBAGA, Jorge; HOFF, Paulo M.; CHAMMAS, Roger- Coping with fluid restriction and the quality of life in hemodialysis patients with very low or no daily urine output(2014) SILVA, Luciana F.; LOPES, Gildete B.; CUNHA, Taline O.; PROTASIO, Bruno M.; PISONI, Ronald L.; JAMES, Sherman A.; LOPES, Antonio A.Purpose: Fluid restriction is crucial to prevent circulatory overload in maintenance hemodialysis (MHD) patients with very low urine volume, but fluid restriction may result in psychological distress. We studied MHD patients with urine volume <= 200 ml/day to investigate if their acceptance of fluid restriction was associated with their health-related quality of life (HRQOL). Methods: Cross-sectional study of 271 Brazilian adult MHD patients enrolled in the Prospective Study of the Prognosis of Chronic Hemodialysis Patients (PROHEMO). To assess the acceptance of fluid restriction, patients were asked about the extent of feeling bothered by living on this restriction. The KDQOL was used to determine HRQOL scores. Higher scores indicate better HRQOL with differences of >3.0 points considered clinically significant. Results: 52.4% reported being ""moderately to extremely"" bothered by fluid restriction and had lower scores for all HRQOL scales than patients less bothered by fluid restriction. The largest covariate-adjusted differences in HRQOL were 19.5 for emotional role (p<0.001), 15.1 for emotional well-being (p<0.001), and 14.1 for vitality (p<0.001). Adjusted differences were larger for mental component (7.53 points, p<0.001) than for physical component (2.07, p = 0.075) summaries. Conclusions: These results indicate that MHD patients with a lower level of acceptance of fluid restriction have poorer HRQOL, particularly in mental domains of HRQOL. The high prevalence of poor acceptance of fluid restriction in the present study underscores the need for interventions to improve acceptance of fluid restriction and determine if such interventions improve HRQOL of MHD patients with very low urine volume.
- Transient acute lateral wall ST elevation myocardial infarction caused by 'benign' circunflex coronary artery anomaly originating from the right coronary artery(2012) PROTASIO, B. M.; GUABIRU, A. T.; DORNELAS, G. De Oliveira; STANIAK, H. Lane; SHAROVSKY, R.; LOTUFO, P. A.; BITTENCOURT, M. S.
bookPart Tratamentos convencionais(2022) SILVA, Bruno Mendonça Protásio da; LORENTE, Sandra; RIBEIRO JUNIOR, Ulysses- Antiepileptic drug prophylaxis in primary brain tumor patients: is current practice in agreement to the consensus?(2014) OLIVEIRA, Julia Andrade de; SANTANA, Iuri A.; CAIRES, Inacelli Q. S.; CAIRES-LIMA, Rafael; MIRANDA, Vanessa Costa; PROTASIO, Bruno M.; ROCHA, Lucila S.; BRAGA, Henrique F.; MENCARINI, Ana M.; TEIXEIRA, Manoel Jacobsen; CASTRO, Luiz Henrique Martins; FEHER, OlavoThe role of antiepileptic drugs (AED) prophylaxis in primary brain tumor (PBT) seizure-na < ve patients remains unclear. Additionally, AED are associated with severe side effects, negative impact on cognition and drug interactions. Little is known about current practice regarding prophylactic AED use in PBT. We investigated its use in a tertiary care cancer center. We reviewed medical records of 260 patients registered in our center between 2008 and 2012, focusing on prophylactic AED use. A descriptive analysis was performed with SPSS IBM version 20.0. Median age was 44.5 years (11-83). Most patients had ECOG PS a parts per thousand currency sign1 (76.4 %). Among 141 seizure-na < ve patients, 70.2 % received an AED as primary prophylaxis (PP). Most commonly used drugs as PP were phenytoin (85.9 %), carbamazepine (6.1 %) and phenobarbital (5.1 %). In only 14 patients (14.1 %) AEDs were eventually discontinued, in a median time of 5.9 months (1.1-76.8 m). AED were used as PP in 60 % of low-grade gliomas, 73.3 % of anaplastic gliomas and 93.9 % of glioblastoma patients. Twenty-seven patients (27.3 %) on PP presented seizures, generally associated with tumor progression. Of the 42 seizure-na < ve patients not receiving AED prophylaxis, only two presented seizures, which occurred during or within the first week post-radiotherapy. In this cross-sectional study, prophylactic AED use in PBT was extremely high. Postoperatively, AED were discontinued in a minority of patients, mostly after a prolonged period. Current prophylactic AED use patterns in PBT are not in accordance with established guidelines.
conferenceObject ERLOTINIB IN METASTATIC PULMONARY ADENOCARCINOMAS HARBOURING EGFR ACTIVATING MUTATIONS, IN SAO PAULO - BRAZIL(2013) CAIRES-LIMA, Rafael; PROTASIO, Bruno M.; TAKAHASHI, Tiago K.; MAK, Milena P.; NAKAZATO, Denyei; MESQUITA, Cristiane S.; TAKAGAKI, Teresa Y.; SOARES, Ibere C.; MELLO, Evandro S.; ALVES, Venancio A.; HOFF, Paulo M.; CASTRO JR., Gilberto