RENATO DO CARMO SAID

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LIM/48 - Laboratório de Imunologia, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 3 de 3
  • article 1 Citação(ões) na Scopus
    Twenty years of successful academic outreach at Nucleo de Medicina Tropical (NACE-NUMETROP/USP) in Santarem, Para
    (2021) SAID, Renato do Carmo; ASSY, Joao Guilherme Pontes Lima; SILVA, Kamila Vieira; BRANDAO, Alisson dos Santos; PINHEIRO, Olivia Campos; ESPER, Helena Rangel; GRYSCHEK, Anna Luiza de Fatima Pinho Lins; BERTOLOZZI, Maria Rita; AMATO, Valdir Sabbaga; BOULOS, Marcos; SEGURADO, Aluisio Augusto Cotrim; GRYSCHEK, Ronaldo Cesar Borges; FRANCA, Francisco Oscar de Siqueira
  • article 4 Citação(ões) na Scopus
    High prevalence of Cryptococcal antigenemia using a finger-prick lateral flow assay in individuals with advanced HIV disease in Santarem Municipality, Brazilian Amazon Basin
    (2021) ASSY, Joao Guilherme Pontes Lima; SAID, Renato do Carmo; PINHEIRO, Olivia Campos; BRANDAO, Alisson dos Santos; BOULWARE, David R.; FRANCA, Francisco Oscar de Siqueira; VIDAL, Jose Ernesto
    There is scarce information about HIV-related cryptococcosis in the Brazilian Amazon basin where laboratory infrastructure is limited. The serum cryptococcal antigen (CrAg) lateral flow assay (LFA) has simplified diagnosis of cryptococcosis and is recommended for screening in advanced HIV disease. We evaluated the prevalence of cryptococcal antigenemia using finger-prick CrAg LFA in the Brazilian Amazon basin. We enrolled a prospective cohort of outpatients and hospitalized individuals with advanced HIV disease at two centers in Santarem Municipality, Northern Brazil. All individuals were > 18 years old with advanced HIV disease, regardless of antiretroviral therapy (ART) status and with no prior or current history of confirmed cryptococcal meningitis. We tested CrAg LFA on finger-prick whole blood using an exact volume transfer pipette. From August 2018 to October 2019, 104 individuals were enrolled (outpatients 62 [60%] and hospitalized 42 [40%]). Median age was 38 years (interquartile range [IQR] 30-46), and 84 (81%) were male. Sixty-five (63%) individuals were ART-naive. Prevalence of finger-prick CrAg LFA-positive was 10.6%; 95% CI, 5.4 to 18.1%. Prevalence of finger-prick CrAg LFA-positive among individuals without neurological symptoms was 6.0%; 95% CI, 1.7-14.6%. The number needed to test to detect one CrAg-positive individual was 9.4 persons (95% CI, 5.5-18.5). Prevalence of cryptococcal antigenemia using finger-prick whole blood CrAg LFA was high. Point-of-care approach was important for the diagnosis and screening of cryptococcosis in resource-limited settings. Screening and preemptive therapy strategy should be urgently implemented in individuals with advanced HIV disease in the Brazilian Amazon basin. Lay Summary This prospective cohort study was carried-out in the Brazilian Amazon basin. We used a cryptococcal rapid test in patients with AIDS. We included 104 participants, and 11 (10.6%) of them had positive results showing a high prevalence of cryptococcal antigenemia.
  • bookPart
    Acidentes por animais peçonhentos
    (2023) TORREZ, Pasesa Pascuala Quispe; DUARTE, Marcelo Ribeiro; SAID, Renato do Carmo; BERTANI, Rogério; HADDAD JUNIOR, Vidal; FRANçA, Francisco Oscar de Siqueira