JACKELINE COUTO ALVARENGA
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
27 resultados
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conferenceObject Cortical Bone Changes in Pre- and Postmenopausal Healthy Women Measured with HR-pQCT(2016) ALVARENGA, Jackeline Couto; PEREIRA, Rosa M. R.- A Randomized Trial of Zoledronic Acid to Prevent Bone Loss in the First Year after Kidney Transplantation(2019) MARQUES, Igor Denizarde Bacelar; ARAUJO, Maria Julia Correia Lima Nepomuceno; GRACIOLLI, Fabiana Giorgetti; REIS, Luciene Machado dos; PEREIRA, Rosa Maria R.; ALVARENGA, Jackeline C.; CUSTODIO, Melani Ribeiro; JORGETTI, Vanda; ELIAS, Rosilene Motta; MOYSES, Rosa Maria Affonso; DAVID-NETO, EliasBackground Bone and mineral disorders commonly affect kidney transplant (KTx) recipients and have been associated with a high risk of fracture. Bisphosphonates may prevent or treat bone loss in such patients, but there is concern that these drugs might induce adynamic bone disease (ABD). Methods In an open label, randomized trial to assess the safety and efficacy of zoledronate for preventing bone loss in the first year after kidney transplant, we randomized 34 patients before transplant to receive zoledronate or no treatment. We used dual-energy x-ray absorptiometry (DXA), high-resolution peripheral quantitative computed tomography (HR-pQCT), and bone biopsies to evaluate changes in bone in the 32 evaluable participants between the time of KTx and 12 months post-transplant. Results Both groups of patients experienced decreased bone turnover after KTx, but zoledronate itself did not affect this outcome. Unlike previous studies, DXA showed no post-transplant bone loss in either group; we instead observed an increase of bone mineral density in both lumbar spine and total hip sites, with a significant positive effect of zoledronate. However, bone biopsies showed post-transplant impairment of trabecular connectivity (and no benefit from zoledronate); HR-pQCT detected trabecular bone loss at the peripheral skeleton, which zoledronate partially attenuated. Conclusions Current immunosuppressive regimens do not contribute to post-transplant central skeleton trabecular bone loss, and zoledronate does not induce ABD. Because fractures in transplant recipients are most commonly peripheral fractures, clinicians should consider bisphosphonate use in patients at high fracture risk who have evidence of significantly low bone mass at these sites at the time of KTx.
conferenceObject Association of Moderate/Severe Vertebral Fractures with Reduced Trabecular Volumetric Bone Density in Older Women and Reduced Areal Femoral Neck Bone Density in Older Men from Community: A Cross-Sectional Study (SPAH)(2018) TORRES, Georgea H. F.; GUZMAN, Luis F. S.; ALVARENGA, Jackeline C.; SR., Levi Neto; CAPARBO, Valeria F.; TAKAYAMA, Liliam; DOMICIANO, Diogo S.; SR., Neusa Lopes; PEREIRA, Rosa M. R.- Association of moderate/severe vertebral fractures with reduced trabecular volumetric bone density in older women and reduced areal femoral neck bone density in older men from the community: A cross-sectional study (SPAH)(2019) TORRES, Georgea H. F.; GUZMAN, Luis F. E.; ALVARENGA, Jackeline C.; LOPES, Neuza H. M.; PEREIRA, Rosa M. R.Background: Many vertebral fractures (VF) occur in individuals classified by DXA as being at low risk of fragility fractures. The aim of this study was to verify the association between VF and peripheral bone microarchitecture and strength parameters (SP) using, in addition to DXA, high-resolution peripheral quantitative computed tomography (HR-pQCT) and axial bone microarchitecture using the trabecular bone score (TBS). Study design: Cross-sectional study of 276 community-dwelling subjects aged >= 65 years from the SPAH study cohort. Methods: Lateral DXA scans of the spine were analyzed to assess VF. HR-pQCT was performed at the radius and tibia. TBS was determined using DXA. Results: VF was observed in 42.6% of women and 28% of men. At the tibia, women with moderate/severe VF had lower volumetric bone density (vBMD), trabecular number (Tb.N), and SP, and higher trabecular separation (Tb.Sp); and men with VF had lower Tb.N and SP, and higher Tb.Sp. At the radius, women with moderate/severe VF had lower vBMD, trabecular and cortical thickness and SP; and men with VF had lower trabecular vBMD and SP. No associations between TBS and VF were observed in either gender. Logistic regression analysis revealed that trabecular vBMD at the tibia in women (OR:0.980, 95%CI:0.963-0.997, p = 0.022) and femoral neck aBMD in men (OR:0.445, 95%0:0.212-0.935, p = 0.033) were independently associated with VF. Conclusion: HR-pQCT images detected differences in bone microstructure in older women with VF independent of aBMD and TBS by DXA, and HR-pQCT could be a useful tool to assess fracture risk. In men, femoral neck aBMD was associated with VF, and DXA continues to be an important tool for predicting VF.
conferenceObject Associations Between Physical Activity And Lower-Limb Strength With Bone Parameters In Healthy Young Women: A Pilot Study(2016) MURAI, Igor Hisashi; DANTAS, Wagner Silva; GIL, Saulo Dos Santos; TEIXEIRA, Eurimar Rogerio; ALVARENGA, Jackeline Couto; BENATTI, Fabiana; PEREIRA, Rosa Maria Rodrigues; ROSCHEL, Hamilton; GUALANO, BrunoconferenceObject BONE IMPAIRMENT ASSESSED BY HR-PQCT IN JUVENILE - ON SET SYSTEMIC LUPUS ERYTHEMATOSUS(2017) PEREIRA, R. M. R.; PAUPITZ, J. A.; LIMA, G. L.; ALVARENGA, J. C.; OLIVEIRA, R. M.; BONFA, E.conferenceObject A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF VITAMIN D SUPPLEMENTATION IN JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: EFFECTS ON MICROARCHITECTURE USING HR-PQCT(2016) PAUPITZ, J. A.; LIMA, G. L.; AIKAWA, N. E.; ALVARENGA, J. C.; BONFA, E.; PEREIRA, R. M. R.conferenceObject Bone Microarchitecture and Bone Strength in Patients with Primary Sjogren's Syndrome: A Case-Control Study Using HR-pQCT(2015) PASOTO, Sandra Gofinet; AUGUSTO, Kristopherson Lustosa; ALVARENGA, Jackeline Couto; TAKAYAMA, Liliam; CAPARBO, Valeria; OLIVEIRA, Ricardo M.; BONFA, Eloisa; PEREIRA, Rosa M. R.conferenceObject Hand Bone Impairment By High-Resolution Peripheral Quantitative Computed Tomography in Patients with Diffuse Systemic Sclerosis: Correlation with Clinical Parameters, Quality of Life and Capillaroscopic Findings(2015) SAMPAIO-BARROS, Marilia; TAKAYAMA, Liliam; ALVARENGA, Jackeline Couto; LUPPINO-ASSAD, Ana Paula; SAMPAIO-BARROS, Percival D.; PEREIRA, Rosa M. R.conferenceObject A Randomised Double-Blind Placebo-Controlled Trial of Vitamin D Supplementation in Juvenile-Onset Systemic Lupus Erythematosus: Effects on Microarchitecture Measured By HR-pQCT(2015) LIMA, Glauce; PAUPITZ, Juliane; AIKAWA, Nadia E.; ALVARENGA, Jackeline Couto; BONFY, Eloisa; PEREIRA, Rosa M. R.
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