ARNALDO JOSE HERNANDEZ
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Ortopediae Traumatologia, Faculdade de Medicina - Docente
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
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- AN INEXPENSIVE METHOD TO MEASURE KNEE EXTENSORS' POWER IN OLDER ADULTS(2015) PINHO, Joao Pedro; MEZENCIO, Bruno; CLAUDINO, Joao Gustavo Oliveira; SONCIN, Rafael; HERNANDEZ, Arnaldo Jose; SERRAO, Julio Cerca; AMADIO, Alberto CarlosIntroduction: Measuring knee extensors' power in elderly population is crucial but not accessible to everyone. Objective: To provide a method to calculate knee extensors' power in a conventional knee extension machine. Method: Thirteen sedentary elderly women (69.3 +/- 4.1 years) performed six knee extensions as fast as possible. Kinematic data, an anthropometric model and Newtonian mechanics was used to write movement equations that allowed calculating knee extensors' power and work. The reliability was assessed by variables' coefficient of variation, intraclass correlation coefficient and standard measurement error. Results: Knee extensors' peak power and work values obtained were in agreement with the literature. We found high intraclass ICC values for both variables (93% and 97%, respectively) and low normalized SEM (10.13% and 2.09%, respectively). Conclusion: We provided an inexpensive method to assess a major physical dysfunction indicator in older adults which can also be used to evaluate the progression of an intervention.
- 3D COMPUTER TOMOGRAPHY FOR MEASUREMENT OF FEMORAL POSITION IN ACL RECONSTRUCTION(2015) FERNANDES, Tiago Lazzaretti; MARTINS, Nuno Miguel Morais Fonseca; WATAI, Felipe de Andrade; NETO, Cyro Albuquerque; PEDRINELLI, Andre; HERNANDEZ, Arnaldo JoseObjective: To validate intra-and inter-class correlation coefficients of a transparent 3D-TC protocol and investigate relationships between different axial rotations. Methods: Twenty unilateral knee TCs (iSite - Philips) were evaluated by means of a transparent 3D-TC OsiriX Imaging Software (v.3.9.4), 3D MPR protocol. Mathematical model of femoral tunnel projections acquired on vertical and horizontal rotations from -20 to +20 degrees. Height (h'/H) and length (t'/T) of tunnel projections have been analyzed by the Bernard and Hertel's method. Statistics: power of study=80%, ICC, ANOVA, p<0.05 (SPSS-19). Results: Transparent 3D-TC showed high reliability of both intra-observer (h'/H= 0.941; t'/T= 0.928, p<0.001) and inter-observer (h'/H= 0.921; t'/T= 0.890, p<0.001) ICC. ACL Length (t'/T) and Height (h'/H) projections were statistically different on vertical and horizontal rotations: p=0.01 and p<0.001, respectively. Conclusion: This new transparent 3DTC protocol is an accurate and reproducible method that can be applied for ACL femoral tunnel or footprint measurement with high ICC reliability.
- Macrophage: A Potential Target on Cartilage Regeneration(2020) FERNANDES, Tiago Lazzaretti; GOMOLL, Andreas H.; LATTERMANN, Christian; HERNANDEZ, Arnaldo Jose; BUENO, Daniela Franco; AMANO, Mariane TamiCartilage lesions and osteoarthritis (OA) presents an ever-increasing clinical and socioeconomic burden. Synovial inflammation and articular inflammatory environment are the key factor for chondrocytes apoptosis and hypertrophy, ectopic bone formation and OA progression. To effectively treat OA, it is critical to develop a drug that skews inflammation toward a pro-chondrogenic microenvironment. In this narrative and critical review, we aim to see the potential use of immune cells modulation or cell therapy as therapeutic alternatives to OA patients. Macrophages are immune cells that are present in synovial lining, with different roles depending on their subtypes. These cells can polarize to pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes, being the latter associated with wound-healing by the production of ARG-1 and pro-chondrogenic cytokines, such as IL-10, IL-1RA, and TGF-b. Emerging evidence reveals that macrophage shift can be determined by several stimuli, apart from the conventional in vitro IL-4, IL-13, and IL-10. Evidences show the potential of physical exercise to induce type 2 response, favoring M2 polarization. Moreover, macrophages in contact with oxLDL have effect on the production of anabolic mediators as TGF-b. In the same direction, type II collagen, that plays a critical role in development and maturation process of chondrocytes, can also induce M2 macrophages, increasing TGF-b. The mTOR pathway activation in macrophages was shown to be able to polarize macrophages in vitro, though further studies are required. The possibility to use mesenchymal stem cells (MSCs) in cartilage restoration have a more concrete literature, besides, MSCs also have the capability to induce M2 macrophages. In the other direction, M1 polarized macrophages inhibit the proliferation and viability of MSCs and impair their ability to immunosuppress the environment, preventing cartilage repair. Therefore, even though MSCs therapeutic researches advances, other sources of M2 polarization are attractive issues, and further studies will contribute to the possibility to manipulate this polarization and to use it as a therapeutic approach in OA patients.
- BRAZILIAN JOURNAL OF SPORTS MEDICINE: TEAM WORK IN THE NAME OF SCIENCE(2011) HERNANDEZ, Arnaldo Jose
- CrossFit Overview: Systematic Review and Meta-analysis(2018) CLAUDINO, Joao Gustavo; GABBETT, Tim J.; BOURGEOIS, Frank; SOUZA, Helton de Sa; MIRANDA, Rafael Chagas; MEZENCIO, Bruno; SONCIN, Rafael; CARDOSO FILHO, Carlos Alberto; BOTTARO, Martim; HERNANDEZ, Arnaldo Jose; AMADIO, Alberto Carlos; SERRAO, Julio CercaBackground: CrossFit is recognized as one of the fastest growing high-intensity functional training modes in the world. However, scientific data regarding the practice of CrossFit is sparse. Therefore, the objective of this study is to analyze the findings of scientific literature related to CrossFit via systematic review and meta-analysis. Methods: Systematic searches of the PubMed, Web of Science, Scopus, Bireme/MedLine, and SciELO online databases were conducted for articles reporting the effects of CrossFit training. The systematic review followed the PRISMA guidelines. The Oxford Levels of Evidence was used for all included articles, and only studies that investigated the effects of CrossFit as a training program were included in the meta-analysis. For the meta-analysis, effect sizes (ESs) with 95% confidence interval (CI) were calculated and heterogeneity was assessed using a random-effects model. Results: Thirty-one articles were included in the systematic review and four were included in the meta-analysis. However, only two studies had a high level of evidence at low risk of bias. Scientific literature related to CrossFit has reported on body composition, psycho-physiological parameters, musculoskeletal injury risk, life and health aspects, and psycho-social behavior. In the meta-analysis, significant results were not found for any variables. Conclusions: The current scientific literature related to CrossFit has few studies with high level of evidence at low risk of bias. However, preliminary data has suggested that CrossFit practice is associated with higher levels of sense of community, satisfaction, and motivation.
- Isokinetic muscle strength and knee function associated with double femoral pin fixation and fixation with interference screw in anterior cruciate ligament reconstruction(2012) FERNANDES, Tiago Lazzaretti; PROTTA, Thiago Rocha; FREGNI, Felipe; BOLLIGER NETO, Raul; PEDRINELLI, Andre; CAMANHO, Gilberto Luis; HERNANDEZ, Arnaldo JoseIntensive scheduling in sports requires athletes to resume physical activity shortly after injury. The purpose of this study was to investigate early isokinetic muscle strength and knee function on bone-patellar tendon-bone (BPTB) ACL reconstruction with double femoral pin fixation or interference screw technique. A prospective study was conducted from 2008 to 2009, with 48 athletes who received femoral BPTB fixation with interference screw (n = 26) or double pin (n = 22). Clinical (IKDC objective score and hop test) and isokinetic muscle strength (peak torque (PT), PT/body weight and flexion/extension rate (F/E) in 60 and 240A degrees/s) were analyzed at 6 months of follow-up. Analysis at baseline showed no differences between groups before surgery related to age, gender, associated injury, Tegner or Lysholm score; thus showing that groups were similar. During follow-up, however, there were significant differences between the two groups in some of the isokinetic muscle strength: PT/BW 60A degrees/s (Double Pin = 200% +/- A 13% vs. Interference Screw = 253% +/- A 16%*, *P = 0.01); F/E 60A degrees/s (Double Pin = 89% +/- A 29%* vs. Interference Screw = 74% +/- A 12%, *P = 0.04). No statistical differences between groups were observed on IKDC objective score, hop test and complications. The significant muscle strength outcome of the interference screw group found in this study gives initial evidence that this fixation technique is useful for athletes that may need accelerated rehabilitation. Early return to sports ability signaled by isokinetic muscle strength is of clinical relevance as it is one of the main goals for athletes' rehabilitation. III.
article Estudo biomecânico do comportamento de diferentes espessuras de capa de cimento ósseo em novo modelo de prótese modular diafisária femoral em cão submetidas a ensaio de torção(2013) NINA, Marcos Ishimoto Della; FERRIGNO, Cassio Ricardo Auada; PEREIRA, Cesar Augusto Martins; ALVES, Flavio Rocha; HERNANDEZ, Arnaldo JoseBackground: The feasibility of modular cemented prosthesis in the femoral diaphysis was demonstrated in dogs, but several authors report loosening of bone-cement-implant interface as a major complication and have yet to reach a consensus on the ideal cement layer thickness for reducing postoperative morbidity. The objective of this study was to evaluate the stabilization of the prosthesis using different thicknesses of cement layer, subjected to torsion forces. Materials, Methods & Results: For this study 48 femurs from 24 dogs weighing over 15 kg were used. The animals used did not have any prior diagnosis of bone or nutritional diseases, which was an exclusion criteria for this study. All biological materials were obtained immediately after death or euthanasia of the animal, and then subjected to conventional storage in a freezer at a temperature of - 24 degrees C. The prosthesis was composed of a cylindrical part with rods for attachment to the intramedullary canal, made of alloy steel 316L. After thawing the femurs and subsequent stabilization at room temperature we performed osteotomies of the femoral diaphysis with an oscillating saw and the installation of the prosthesis. As preparatory measures for prosthesis fixation with cement, the intramedullary canals were cleaned, washed with saline and aspirated. They were separated in four groups, the first group with eight femurs used a cement mantle of 1.0 to 1.5 mm, the second group, with eight femurs, used a cement mantle of 2.0 to 2.5 mm and the third group, with eight femurs, used a cement layer of 3.0 to 3.5 mm. The femurs were submitted to destructive torsion tests using a universal testing machine with a load cell of 981 N (100 kg) and an essay speed of 22 mm / min. They were evaluated due to the values of torsional rigidity and maximum torque shown by the implant, bone and bone cement interface. The fourth group consisted of the remaining intact femurs, they were evaluated using the same torsion test used on the other groups. The results were analyzed using the Statistical Analysis System (SAS, 2001) and the normality of residuals was previously verified by the Shapiro-Wilk test. It was established to conduct the testing using an external rotation protocol in order to standardize, assuming a situation where the dog was in movement during a uniform curvilinear motion, trying to mimic a situation where the rotational forces were acting more significantly on the femur. Discussion: In our study the importance of cleaning up the intramedullary canal for proper bone cement penetration, a good reaming of the intramedullary canal and drying the area before the cement implantation was made clear. Statistical analysis showed that the thicknesses of the cement layer ranging from 1 mm to 2.5 mm, although bringing a gradual increase in maximum torque and torsional rigidity, are not sufficient to be statistically significant and may be considered equal in their biomechanical behavior assessed by this study. A similar result was found when we compared the 2 mm to 3.5 mm layers. The comparison that was statistically significant and can be considered in relation to the different biomechanical behavior of the cement layer was seen between the group I of 1 mm to 1.5 mm, and group III of 3 mm to 3.5 mm. Although some results were not statistically significant we must remember that, in absolute values, the torsional rigidity and maximum torque increased linearly with the increasing of the cement layer. From these results we can infer about the real advantage of using a thicker cement layer over an increment in the diameter of the intramedullary component, giving greater resistance to the prosthesis.- BILATERAL LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS OF THE KNEE: CASE REPORT AND REVIEW(2018) FERNANDES, Tiago Lazzaretti; VIDEIRA, Livia Dau; SASAKI, Sandra Umeda; NATALINO, Renato Jose Mendonca; ALMEIDA, Adriano Marques de; PEDRINELLI, Andre; HERNANDEZ, Arnaldo JoseObjectives: Several cases of bilateral diffuse pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor have been described in the literature. Nevertheless, some presentations are rare and differential diagnoses are necessary. Methods: The purpose of this study was to perform a systematic review of the literature related to PVNS and to report a rare supra-patellar bilateral and focal presentation. We performed a systematic data review in the Pubmed Clinical Queries database using MeSH and keywords related to PVNS and tenosynovial giant cell tumor. Results: Two cases of bilateral and local PVNS had been previously described, but neither was localized in the supra-patellar compartment. To our knowledge, this case report is the first to describe supra-patellar bilateral and localized PVNS of the knee. This case involves a 28-year-old woman with bilateral localized PVNS of the supra-patellar recess of the knee. MRI showed a low-signal intensity nodule in T1-and T2-weighted images. These were associated with hemosiderin pigmentation. Conclusion: The most important finding of the case reported is related to rarity and location. Histopathology analysis confirmed a rare case of hemosiderin pigmentation in the capsular nodule with internal non-pigmented villous content. Lipoma arborescens in the supra-patellar form must be ruled out as a differential diagnosis since it occurs in the same site.
- THE NATURAL HISTORY OF THE ANTERIOR KNEE INSTABILITY BY STRESS RADIOGRAPHY(2014) REZENDE, Marcia Uchoa de; HERNANDEZ, Arnaldo Jose; CAMANHO, Gilberto LuisObjective: To analyze the anteroposterior displacement of the knee by means of stress radiography in individuals with unilateral anterior knee instability and relate to time of instability. Methods: Sixty individuals with intact knees (control group) and 125 patients with unilateral anterior instability (AI group) agreed to participate in the study. Gender, age, weight, height, age at injury, time between injury and testing, and surgical findings are studied. Both groups are submitted to anterior and posterior stress radiographies of both knees. Anterior (ADD) and posterior displacement difference (PDD) were calculated between sides. Results: In the control group ADD and PDD are in average, zero, whereas in the AI group ADD averaged 9.8mm and PDD, 1.92mm. Gender, age, weight, height, age at trauma and presence of menisci's lesions do not intervene in the values of ADD and PDD. Meniscal injuries increase with time. ADD and PDD do not relate with the presence or absence of associated menisci's lesions. The ADD and the PDD are related to each other and increase with time. Conclusion: There is a permanent anterior subluxation of the injured knee that is related to the amount of anterior displacement that increases with time. Level of Evidence III, Study Types Case-control study.
- Locking intramedullary nails compared with locking plates for two- and three-part proximal humeral surgical neck fractures: a randomized controlled trial(2016) GRACITELLI, Mauro E. C.; MALAVOLTA, Eduardo A.; ASSUNCAO, Jorge H.; KOJIMA, Kodi E.; REIS, Paulo R. dos; SILVA, Jorge S.; FERREIRA NETO, Arnaldo A.; HERNANDEZ, Arnaldo J.Background: Previous studies have shown good clinical results in patients with proximal humeral fractures (PHFs) treated with locking intramedullary nails or locking plates. Our study compared the clinical and radiographic outcomes in patients with 2- and 3-part surgical neck fractures. Methods: In this prospective, randomized controlled trial, 72 patients with 2- or 3-part surgical neck PHFs were randomly assigned to receive fixation with locking intramedullary nails (nail group) or locking plates (plate group). The primary outcome was the 12-month Constant-Murley score. The secondary outcomes included the Disabilities of the Arm, Shoulder and Hand score, the visual analog scale pain score, the shoulder passive range of motion, the neck-shaft angle, and complication rates. Results: There was no significant mean treatment group difference in the Constant-Murley score at 12 months (70.3 points for the nail group vs. 71.5 points for the plate group; P=.750) or at individual follow-up assessments. There were no differences in the 3-, 6- and 12-month Disabilities of the Arm, Shoulder and Hand scores, visual analog scale scores, and range of motion, except for the medial rotation at 6 months. The neck-shaft angle was equivalent between the groups at 12 months. There were significant differences over 12 months in total complication rates (P=.002) and reoperation rates (P=.041). There were no significant differences for the rotator cuff tear rate (P=.672). Conclusion: Fixation of PHFs with locking plates or locking intramedullary nails produces similar clinical and radiologic results. Nevertheless, the complication and reoperation rates were higher in the nail group. Level of evidence: Level I; Randomized controlled trial; Treatment study (C) 2016 Journal of Shoulder and Elbow Surgery Board of Trustees.