ALEXANDRE MOULIN NAUMANN

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  • article 1 Citação(ões) na Scopus
    The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43
    (2019) TREVISAN, Alexandre Maximiliano; COGLIATI, Bruno; HOMEM, Adriana Ribeiro; ALOIAV, Thiago Pinheiro Arrais; AQUINO NETO, Nelson de; MOREIRA, Jairo Marques; RENO, Leonardo da Cruz; NAUMANN, Alexandre Moulin; GALVAO, Flavio Henrique Ferreira; ANDRAUS, Wellington; D'ALBUQUERQUE, Luiz Augusto Carneiro
    Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST, ALT, GGT) and histology. Results: The mice with Cx43 deficiency showed an ALT mean value of 4166 vs. 307 in the control group (p<0.001); AST mean value of 7231 vs. 471 in the control group (p<0.001); GGT mean value of 9.4 vs. 1.7 in the control group (p=0.001); histology showed necrosis and inflammation in the knockout group. Conclusions: This research demonstrated that the deficiency of Cx43 worses the prognosis for liver injury. The topic is a promising target for therapeutics advancements in liver diseases and procedures.