GABRIEL OKAWA BELIZARIO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
33 resultados
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Agora exibindo 1 - 10 de 33
- Psychological evaluation of children victims of sexual abuse: development of a protocol(2020) MARQUES, Natali Maia; BELIZARIO, Gabriel Okawa; ROCCA, Cristiana Castanho de Almeida; SAFFI, Fabiana; BARROS, Daniel Martins de; SERAFIM, Antonio de PaduaSexual abuse (SA) is associated with significant psychological problems in childhood, making it increasingly important to develop evaluation protocols. This study examined clinical aspects and cognitive measures of 49 children (24 with SA history and 25 controls). It employed a SA assessment questionnaire, clinical evaluations of posttraumatic stress disorder, risk indicators and neuropsychological tests in order to elaborate a specific forensic psychological evaluation protocol for this population. Conflicting couples (80%), separated parents (68%) and parents' alcohol/drug abuse (76%) were revealed as major risk factors. Fathers represented the primary perpetrator (24%). The main cognitive complaint was difficulty concentrating. Regarding the association between clinical and cognitive variables, it was observed that children who were anxious or referred to having fear, difficulties with operational memory and difficulty sleeping, had more trouble performing tasks that required attention and memory (operational, immediate and late). Children with SA history demonstrated inferior performance in visual attention/task switching and memory; with an emphasis in the loss of set in the Wisconsin test. The findings suggest the possibility of a primary attention deficit in children with SA history, possibly influencing the performance of other cognitive functions.
conferenceObject The impact of structured physical exercise on cognitive function of bipolar patients: A study protocol for a randomized controlled trial(2023) BELIZARIO, Gabriel; DUARTE, Cicera; NEVES, Lucas; MATHIAS, Karla; LAFER, Beny- Predominant polarity classification and associated clinical variables in bipolar disorder: A machine learning approach(2019) BELIZARIO, Gabriel Okawa; BORGES JUNIOR, Renato Gomes; SALVINI, Rogerio; LAFER, Beny; DIAS, Rodrigo da SilvaBackground: Bipolar disorder (BD) is a severe psychiatric disorder characterized by periodic episodes of manic and depressive symptomatology. Predominant polarity (PP) appears to be an important specifier of BD. The present study employed machine learning (ML) algorithms to accurately determine a patient ' s PP without the inclusion of number and polarity of past episodes, while exploring associations between PP and demographic and clinical variables. Methods: From a cohort of 148 BD patients, demographic and clinical variables were collected using a customized questionnaire and the SCID-CV. The algorithm employed was the Random-Forest method. The algorithm was programed to classify patients into either depressive or manic predominant polarities and to reveal which variables were associated to the specifier. Results: The algorithm attained an AUC ROC of 74.72% (95% CI = 72.29-77.15%) in classifying patients into either manic or depressive PP. The variables selected by the algorithm were: (1) age at first depressive episode; (2) number of hospitalizations; (3) BD Type II; (4) manic onset; (5) delusions; (6) psychotic features at onset; (7) tobacco addiction; (8) family history of BD; (9) hallucinations; and (10) comorbid anxiety disorders, (11) alcohol dependence, (12) eating disorders and (13) substance dependence. Limitations: The study is limited due to the small sample size, the inclusion of only self-reported and clinician-observed clinical variables and its cross-sectional design. Discussion: The results suggest that the ML approach could be effective in determining a patient ' s PP. Furthermore, although not previously reported, some variables, such as tobacco use and comorbid eating disorders, appear to be closely associated with PP.
- Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder(2021) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kursat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; VARES, Edgar Arrua; AYDIN, Memduha; CHIESA, Silvia; CROWE, Marie; CUOMO, Alessandro; DALLASPEZIA, Sara; ZOMPO, Maria Del; DESAI, Pratikkumar; DODD, Seetal; DONIX, Markus; ETAIN, Bruno; FAGIOLINI, Andrea; MOSCA, Enrica; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; FRYE, Mark A.; GEOFFROY, Pierre A.; GONZALEZ-PINTO, Ana; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; MOZZHEGOROV, Anton A.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; ISOMETSA, Erkki T.; IVKOVIC, Maja; JANNO, Sven; JOHNSEN, Simon; MUNOZ, Rodrigo; KAPCZINSKI, Flavio; KARAKATSOULIS, Gregory N.; KARDELL, Mathias; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; V, Starlin Mythri; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; LEWITZKA, Ute; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; NACEF, Fethi; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; MARTINY, Klaus; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; NADELLA, Ravi K.; MING, Mok Yee; MONTEITH, Scott; MOORTHY, Muthukumaran; MORKEN, Gunnar; NAKANOTANI, Takako; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; AYHAN, Yavuz; OSHER, Yamima; OUALI, Uta; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; PETITE, Joanne; PFENNIG, Andrea; RUIZ, Yolanda Pica; PILHATSCH, Maximilian; PINNA, Marco; POMPILI, Maurizio; BAETHGE, Christopher; PORTER, Richard; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; RAMESAR, Raj; RASGON, Natalie; RATTA-APHA, Woraphat; RATZENHOFER, Michaela; REDAHAN, Maria; REDDY, M. S.; REIF, Andreas; BAUER, Rita; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; RYBAKOWSKI, Janusz K.; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SEVERUS, Emanuel; SMITH, Daniel; SMITH, Jose; BAUNE, Bernhard T.; STACKHOUSE JR., Paul W.; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.; TATEBAYASHI, Yoshitaka; BALABAN, Ceylan; TEH, Wen Lin; TONDO, Leonardo; TORRENT, Carla; TUINSTRA, Daniel; UCHIDA, Takahito; VAALER, Arne E.; VEEH, Julia; VIETA, Eduard; VISWANATH, Biju; YOLDI-NEGRETE, Maria; BECERRA-PALARS, Claudia; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; ZGUEB, Yosra; WHYBROW, Peter C.; BEHERE, Aniruddh P.; BEHERE, Prakash B.; BELETE, Habte; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. WoBackground Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun's electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
- Evidence of validity and reliability of the Desiderative Questionnaire with juvenile offenders and victimized adolescents(2022) TARDIVO, Leila Salomão de La Plata Cury; PINTO JUNIOR, Antonio Augusto; ROSA, Helena Rinaldi; BELIZARIO, Gabriel Okawa; MEDEIROS, DanutaAbstract The objective of this work was to assess validity and reliability of the Desiderative Questionnaire with adolescent offenders and victims. The sample comprised 200 adolescents, of both genders, between 12 and 16 years of age, of whom 50 were sentenced to correctional measures, 50 were victims of domestic violence and 100 without suspected violence or transgression. Data analysis was performed using the Pearson Chi-Square Test, Kappa Concordance Index and Cronbach’s Alpha. The results showed statistically significant differences between the clinical and control groups in several categories, with more difficulties among adolescent victims and offenders. They also revealed precision of the technique used and of the evaluation system with high correlations among the judges as well as high internal consistency, with adequate reliability coefficients.
- Facial Emotion Recognition in Maltreated Children: A Systematic Review(2020) ASSED, Mariana Medeiros; KHAFIF, Tatiana Cohab; BELIZARIO, Gabriel Okawa; FATORELLI, Raquel; ROCCA, Cristiana Castanho de Ameida; SERAFIM, Antonio de PaduaObjectives We systematically reviewed controlled studies published in the last 16 years about emotion recognition deficits in maltreated children. Methods A bibliographical research of controlled studies, including only studies with samples larger than 10 participants, from 1998 to 2017, was conducted on Medline, Lilacs, PubMed and ISI. A total of 31 articles were included in this review. Results Abused children have a recognition bias for negative expressions, especially fear and anger. This increased perception tends to impair interpersonal relationships throughout their development. However, it appears as a matter of necessity, related to survival in a hostile environment. Moreover, neglected children have a shorter reaction time for recognition of negative facial expressions. Thus, the consequence of this deficit generates losses, such as the difficulty of ability to perceive a situation that puts them at risk. Conclusions Children victims of severe domestic violence, as well as those who have been sexually abused and neglected, experience a learning situation regarding past experiences. The losses appear both in abnormal anatomical brain and physiological formations, as well as psychological and behavioral changes that impact the lives of these individuals. These changes are associated to changes mainly in circuits related to the prefrontal cortex and limbic regions, which are responsible for regulating the reaction to a threat. Future studies should develop programs, focusing not only in the prevention of adverse family environments and domestic violence, but also in helping these children improve psychosocial adaptation.
conferenceObject Structured physical exercise in bipolar depression: A pilot study(2020) DUARTE, Cicera; BELIZARIO, Gabriel O.; MATHIAS, Karla; SILVA, Michele; ROBERTO, Paulo; GREVE, Julia; LAFER, Beny- Cognitive behavioral rehabilitation for bipolar disorder patients: A randomized controlled trial(2019) GOMES, Bernardo C.; ROCCA, Cristiana C.; BELIZARIO, Gabriel O.; FERNANDES, Francy de B. F.; VALOIS, Iolanda; OLMO, Giselle C.; FACHIN, Raquel V. P.; FARHAT, Luis C.; LAFER, BenyObjectives Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions have been proposed to address these outcomes but positive results are still scarce. The objective of the present study is to evaluate the efficacy of a new intervention developed to address both cognitive and functional impairment. Methods Thirty-nine individuals were included in this randomized controlled trial. All participants were evaluated by the Cambridge Neuropsychological Test Automated Battery (CANTAB) and completed functional and quality of life (QOL) scales. Patients were randomized to either treatment as usual (TAU) or Cognitive Behavior Rehabilitation (CBR), an add-on treatment delivered in 12 weekly group sessions. All individuals were revaluated after 12 weeks. Results A total of 39 bipolar type I or II patients were included in the analysis, 19 in the TAU group and 20 in the CBR condition. At the entrance of the study, both groups were statistically similar regarding clinical, socio-demographics and cognitive variables. After the end of the intervention, CBR individuals had significantly improved reaction time, visual memory and emotion recognition. In contrast, individuals in the CBR did not present a statistically change in functional and QOL scores after the 12-week intervention. Conclusions CBR intervention showed promising results in improving some of the commonly impaired cognitive domains in BD. A longer follow-up period may be necessary to detect changes in functional and QOL domains.
conferenceObject Cognitive profile of bipolar disorder patients: A 12-year prospective study(2019) WOSNES, C. J.; ROCCA, C. C.; BELIZARIO, G. O.; LAFER, B.; NUNES, P. V.- Association between polarity of first episode and solar insolation in bipolar I disorder(2022) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kursat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; AYDIN, Memduha; AYHAN, Yavuz; DODD, Seetal; ETAIN, Bruno; FAGIOLINI, Andrea; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; FRYE, Mark A.; GEOFFROY, Pierre A.; GONZALEZ-PINTO, Ana; MUNOZ, Rodrigo; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; ISOMETSA, Erkki T.; V, Starlin Mythri; IVKOVIC, Maja; JANNO, Sven; JOHNSEN, Simon; KAPCZINSKI, Flavio; KARAKATSOULIS, Gregory N.; KARDELL, Mathias; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; NACEF, Fethi; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; LEWITZKA, Ute; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; NADELLA, Ravi K.; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; MARTINY, Klaus; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; NAKANOTANI, Takako; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; MOK, Yee Ming; MONTEITH, Scott; MOORTHY, Muthukumaran; MORKEN, Gunnar; MOSCA, Enrica; MOZZHEGOROV, Anton A.; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; OSHER, Yamima; OUALI, Uta; BAETHGE, Christopher; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; PETITE, Joanne; PFENNIG, Andrea; RUIZ, Yolanda Pica; PINNA, Marco; POMPILI, Maurizio; PORTER, Richard; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; BAUER, Rita; RAMESAR, Raj; RASGON, Natalie; RATTA-APHA, Woraphat; RATZENHOFER, Michaela; REDAHAN, Maria; REDDY, M. S.; REIF, Andreas; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; BAUNE, Bernhard T.; RYBAKOWSKI, Janusz K.; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SMITH, Daniel; SMITH, Jose; STACKHOUSE, Paul W.; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; BALABAN, Ceylan; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.; TATEBAYASHI, Yoshitaka; TEH, Wen Lin; TONDO, Leonardo; TORRENT, Carla; TUINSTRA, Daniel; BECERRA-PALARS, Claudia; UCHIDA, Takahito; VAALER, Arne E.; VIETA, Eduard; VISWANATH, Biju; YOLDI-NEGRETE, Maria; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; ZGUEB, Yosra; WHYBROW, Peter C.; BEHERE, Aniruddh P.; BEHERE, Prakash B.; BELETE, Habte; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. W.; CHIESA, Silvia; CROWE, Marie; CUOMO, Alessandro; DALLASPEZIA, Sara; ZOMPO, Maria Del; DESAI, PratikkumarObjective: Circadian rhythm disruption is commonly observed in bipolar disorder (BD). Daylight is the most powerful signal to entrain the human circadian clock system. This exploratory study investigated if solar inso-lation at the onset location was associated with the polarity of the first episode of BD I. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area of the Earth. Methods: Data from 7488 patients with BD I were collected at 75 sites in 42 countries. The first episode occurred at 591 onset locations in 67 countries at a wide range of latitudes in both hemispheres. Solar insolation values were obtained for every onset location, and the ratio of the minimum mean monthly insolation to the maximum mean monthly insolation was calculated. This ratio is largest near the equator (with little change in solar insolation over the year), and smallest near the poles (where winter insolation is very small compared to summer insolation). This ratio also applies to tropical locations which may have a cloudy wet and clear dry season, rather than winter and summer. Results: The larger the change in solar insolation throughout the year (smaller the ratio between the minimum monthly and maximum monthly values), the greater the likelihood the first episode polarity was depression. Other associated variables were being female and increasing percentage of gross domestic product spent on country health expenditures. (All coefficients: P <= 0.001). Conclusion: Increased awareness and research into circadian dysfunction throughout the course of BD is warranted.