Impact of baseline abnormal liver enzymes in the outcome of COVID-19 infection
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | FARIAS, Joao Pedro | |
dc.contributor.author | CODES, Liana | |
dc.contributor.author | VINHAES, Diana | |
dc.contributor.author | AMORIM, Ana Paula | |
dc.contributor.author | D'OLIVEIRA, Ricardo Cruz | |
dc.contributor.author | FARIAS, Alberto Queiroz | |
dc.contributor.author | BITTENCOURT, Paulo Lisboa | |
dc.date.accessioned | 2024-04-05T19:31:34Z | |
dc.date.available | 2024-04-05T19:31:34Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Background: Little is known about the significance of liver function tests (LFT) abnormalities in COVID-19 and their impact on disease outcomes. The aims of the study were to evaluate abnormalities of LFT in patients with COVID-19 and their impact on disease severity, mortality, and correlation with leukocyte markers of inflammation. Methods: All patients with COVID-19 admitted to the emergency department (ED) of a single reference center were retrospectively evaluated. Data were collected using an electronic medical database covering the following variables: demographics, baseline complete blood count (CBC) and ratios, neutrophillymphocyte (NLR) and monocyte-lymphocyte ratios (MLR), systemic immune-inflammation index (SII), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Disease severity was defined by the presence of organ failure (OF) or requirement for intensive care unit (ICU) support. Mortality was considered as patient death during hospitalization. Results: A total of 1,539 subjects (799 women, mean age 57 +/- 18 years) with COVID-19 were evaluated. Abnormal AST and/or ALT were seen in 50% of them, with a frequency and magnitude that significantly correlated with leukocyte count and ratios. Both LFT were significantly associated with requirement for hospital and ICU admission and mortality. High AST levels were significantly associated with the presence, number, and types of OFs and in-hospital length of stay (LOS). Elevated ALT was also significantly associated with the aforementioned variables, with the exception of OFs presence, circulatory failure and LOS. Conclusions: LFT abnormalities are frequently seen in COVID-19 patients, reflect SARS-CoV-2 associated inflammation and may predict adverse outcomes. LFT may be useful to aid decision-making in the ED for hospital admission or scheduled outpatient reevaluation. | eng |
dc.description.index | PubMed | |
dc.description.index | Scopus | |
dc.description.index | Dimensions | |
dc.description.index | WoS | |
dc.identifier.citation | TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY, v.8, article ID 5, 9p, 2023 | |
dc.identifier.doi | 10.21037/tgh-22-41 | |
dc.identifier.eissn | 2415-1289 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/58874 | |
dc.language.iso | eng | |
dc.publisher | AME PUBLISHING COMPANY | eng |
dc.relation.ispartof | Translational Gastroenterology and Hepatology | |
dc.rights | openAccess | eng |
dc.rights.holder | Copyright AME PUBLISHING COMPANY | eng |
dc.subject | Liver enzymes | eng |
dc.subject | COVID-19 | eng |
dc.subject | mortality | eng |
dc.subject.other | injury | eng |
dc.subject.wos | Gastroenterology & Hepatology | eng |
dc.title | Impact of baseline abnormal liver enzymes in the outcome of COVID-19 infection | eng |
dc.type | article | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
dspace.entity.type | Publication | |
hcfmusp.author.external | FARIAS, Joao Pedro:Univ Salvador Unifacs, Salvador, BA, Brazil | |
hcfmusp.author.external | CODES, Liana:Portuguese Hosp Bahia, Salvador, BA, Brazil; Bahiana Sch Med & Publ Hlth, Salvador, BA, Brazil | |
hcfmusp.author.external | VINHAES, Diana:Portuguese Hosp Bahia, Salvador, BA, Brazil | |
hcfmusp.author.external | AMORIM, Ana Paula:Portuguese Hosp Bahia, Salvador, BA, Brazil | |
hcfmusp.author.external | D'OLIVEIRA, Ricardo Cruz:Portuguese Hosp Bahia, Salvador, BA, Brazil; Bahiana Sch Med & Publ Hlth, Salvador, BA, Brazil | |
hcfmusp.author.external | BITTENCOURT, Paulo Lisboa:Portuguese Hosp Bahia, Salvador, BA, Brazil; Bahiana Sch Med & Publ Hlth, Salvador, BA, Brazil | |
hcfmusp.citation.scopus | 0 | |
hcfmusp.contributor.author-fmusphc | ALBERTO QUEIROZ FARIAS | |
hcfmusp.description.articlenumber | 5 | |
hcfmusp.description.volume | 8 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.dimensions | pub.1152268387 | |
hcfmusp.origem.pubmed | 36704646 | |
hcfmusp.origem.scopus | 2-s2.0-85176219204 | |
hcfmusp.origem.wos | WOS:000878473000001 | |
hcfmusp.publisher.city | SHATIN | eng |
hcfmusp.publisher.country | PEOPLES R CHINA | eng |
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hcfmusp.scopus.lastupdate | 2024-05-17 | |
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