Artigos e Materiais de Revistas Científicas - COVID-19

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A coleção de Artigos e Materiais de Revistas Científicas engloba artigos originais, artigos de revisão, artigos de atualização, artigos técnicos, relatos de experiências, resenhas, ensaios, editoriais, cartas ao editor, debates, notas científicas e técnicas, depoimentos, entrevistas e pontos de vista. Consideram-se como artigos científicos originais os trabalhos redigidos para divulgação de informações e resultados sobre determinada pesquisa científica, publicados em periódico científico após avaliação por outros pesquisadores.


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  • article 40 Citação(ões) na Scopus
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
    (2023) PAIRO-CASTINEIRA, Erola; RAWLIK, Konrad; BRETHERICK, Andrew D.; QI, Ting; WU, Yang; NASSIRI, Isar; MCCONKEY, Glenn A.; ZECHNER, Marie; KLARIC, Lucija; GRIFFITHS, Fiona; OOSTHUYZEN, Wilna; KOUSATHANAS, Athanasios; RICHMOND, Anne; MILLAR, Jonathan; RUSSELL, Clark D.; MALINAUSKAS, Tomas; THWAITES, Ryan; MORRICE, Kirstie; KEATING, Sean; MASLOVE, David; NICHOL, Alistair; SEMPLE, Malcolm G.; KNIGHT, Julian; SHANKAR-HARI, Manu; SUMMERS, Charlotte; HINDS, Charles; HORBY, Peter; LING, Lowell; MCAULEY, Danny; MONTGOMERY, Hugh; OPENSHAW, Peter J. M.; BEGG, Colin; WALSH, Timothy; TENESA, Albert; FLORES, Carlos; RIANCHO, Jose A.; ROJAS-MARTINEZ, Augusto; LAPUNZINA, Pablo; YANG, Jian; PONTING, Chris P.; WILSON, James F.; VITART, Veronique; ABEDALTHAGAFI, Malak; LUCHESSI, Andre D.; PARRA, Esteban J.; CRUZ, Raquel; CARRACEDO, Angel; FAWKES, Angie; MURPHY, Lee; ROWAN, Kathy; PEREIRA, Alexandre C.; LAW, Andy; FAIRFAX, Benjamin; HENDRY, Sara Clohisey; BAILLIE, J. Kenneth
    Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown(1) to be highly efficient for discovery of genetic associations(2). Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group(3). Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte-macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A). An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte-macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).
  • article 2 Citação(ões) na Scopus
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (vol 617, pg 764, 2023)
    (2023) PAIRO-CASTINEIRA, Erola; RAWLIK, Konrad; BRETHERICK, Andrew D.; QI, Ting; WU, Yang; NASSIRI, Isar; MCCONKEY, Glenn A.; ZECHNER, Marie; KLARIC, Lucija; GRIFFITHS, Fiona; OOSTHUYZEN, Wilna; KOUSATHANAS, Athanasios; RICHMOND, Anne; MILLAR, Jonathan; RUSSELL, Clark D.; MALINAUSKAS, Tomas; THWAITES, Ryan; MORRICE, Kirstie; KEATING, Sean; MASLOVE, David; NICHOL, Alistair; SEMPLE, Malcolm G.; KNIGHT, Julian; SHANKAR-HARI, Manu; SUMMERS, Charlotte; HINDS, Charles; HORBY, Peter; LING, Lowell; MCAULEY, Danny; MONTGOMERY, Hugh; OPENSHAW, Peter J. M.; BEGG, Colin; WALSH, Timothy; TENESA, Albert; FLORES, Carlos; RIANCHO, Jose A.; ROJAS-MARTINEZ, Augusto; LAPUNZINA, Pablo; YANG, Jian; PONTING, Chris P.; WILSON, James F.; VITART, Veronique; ABEDALTHAGAFI, Malak; LUCHESSI, Andre D.; PARRA, Esteban J.; CRUZ, Raquel; CARRACEDO, Angel; FAWKES, Angie; MURPHY, Lee; ROWAN, Kathy; PEREIRA, Alexandre C.; LAW, Andy; FAIRFAX, Benjamin; HENDRY, Sara Clohisey; BAILLIE, J. Kenneth
  • article 0 Citação(ões) na Scopus
    Longitudinal strain and myocardial work in symptomatic patients having recovered from COVID-19 and possible associations with the severity of the disease
    (2024) D'AVILA, Luciana Bartolomei Orru; MILANI, Mauricio; BIHAN, David C. S. Le; LIMA, Alexandra Correa Gervazoni Balbuena de; MILANI, Juliana Goulart Prata Oliveira; CIPRIANO, Graziella Franca Bernardelli; SILVA, Vinicius Zacarias Maldaner da; JR, Gerson Cipriano
    COVID-19 may have residual consequences in multiple organs, including the cardiovascular system. The purpose of the present investigation is to quantify myocardial function in symptomatic individuals with long COVID and investigate the association between illness severity and myocardial function. A retrospective cross-sectional study was conducted in which symptomatic individuals with previous COVID-19 underwent echocardiographic analysis of left ventricle global longitudinal strain (LVGLS) and myocardial work (MW). Individuals also performed cardiopulmonary testing (CPX) to assess peak oxygen uptake (VO2peak). Differences between illness severity subgroups were analyzed by the Mann-Whitney test. Correlations were calculated using the Spearman correlation test. Multilinear regressions were performed to evaluate the influences of COVID-19 severity, body mass index, age, and sex on MW. Fifty-six individuals were included (critical subgroup: 17; moderate/severe subgroup: 39), 59% females; median age: 56 years (IQR: 43-63). CPX revealed a substantial reduction in VO2peak (median of 53% of predicted values). LVGLS were not statistically different between subgroups. Global wasted work (GWW) was higher in the critical subgroup [146 (104-212) versus 121 (74-163) mmHg%, p = 0.01], and global work efficiency (GWE) was lower in this subgroup [93 (91-95) versus 94 (93-96), p = 0.03]. Illness severity was the only independent predictor of GWW and GWE (GWW: r2 = 0.167; p = 0.009; GWE: r2 = 0.172; p = 0.005) in multilinear regressions. In our study with long COVID-19 individuals, despite having a similar LVGLS, patients had subclinical LV dysfunction, demonstrated only by an increase in GWW and a decrease in GWE.
  • article
    Impact of the COVID-19 pandemic on the symptomatology and routine of medicated patients with obsessivecompulsive disorder
    (2024) ALMEIDA, Natalia B.; MAZIERO, Maria Paula; TANAMATIS, Tais; COSTA, Danel Lucas da Conceicao; SHAVITT, Roseli G.; HOEXTER, Marcelo Q.; BATISTUZZO, Marcelo C.
    OBJECTIVES: To study the impact of coronavirus disease 2019 on the routine of patients with obsessive-compulsive disorder (OCD) and changes in symptoms and suicidal-related behavior, mainly in those with cleaning symptoms.
    METHODS: In this cross-sectional study, 58 patients completed an online self-report questionnaire that included the Obsessive-Compulsive Inventory-Revised, Coronavirus Stress and Traumatic Events Scale, Coronavirus Health Impact Survey, Beck Anxiety and Beck Depression inventories, and Suicide-Related Behaviors Questionnaire. Comparisons were made with another pre-pandemic sample (n=524) regarding the last three measures.
    RESULTS: During the pandemic, the patients spent more days inside their homes (chi(2) = 33.39, p = 0.007), changed their alcohol consumption patterns (chi(2) = 87.6, p < 0.001), and increased social media usage (chi(2) = 68.83, p < 0.001). Participants with cleaning symptoms did not significantly differ from the others in relation to stress, anxiety/depressive symptoms, or suicidal-related behaviors. Finally, our sample did not differ from an equivalent OCD sample assessed before the pandemic in terms of anxiety and depressive symptom severity or suicidal-related behaviors.
    CONCLUSION: Overall, patients with OCD showed no lifestyle changes associated with higher stress levels during the pandemic. Patients with and without cleaning symptoms and patients before and during the pandemic presented similar results.
  • article 0 Citação(ões) na Scopus
    Cognitive performance of post-covid patients in mild, moderate, and severe clinical situations
    (2024) SERAFIM, Antonio de Padua; SAFFI, Fabiana; SOARES, Amanda Rafaella A.; MORITA, Alessandra Mara; ASSED, Mariana Medeiros; TOLEDO, Sandro de; ROCCA, Cristiana C. A.; DURAES, Ricardo S. S.
    Background Studying individuals with varying symptoms, from mild to severe, can provide valuable insights into the spectrum of cognitive outcomes after COVID-19. We investigated the cognitive performance of adults who recovered from the novel coronavirus disease (COVID-19) without prior cognitive complaints, considering mild (not hospitalized), moderate (ward), and severe (intensive care unit) symptoms.Methods This cross-sectional study included 302 patients who recovered from COVID-19 (mild, n = 102; moderate, n = 102; severe, n = 98). We assessed intellectual quotient (IQ), attention, memory, processing speed, visual-constructive ability, as well as symptoms of depression, anxiety, and stress, at least eighteen months after infection. The mean length of hospitalization was M days=8.2 (SD = 3.9) and M days=14.4 (SD = 8.2) in the moderate and severe groups, respectively.Results Cognitive difficulties were present in all three groups: mild (n = 12, 11.7%), moderate (n = 40, 39.2%), and severe (n = 48, 48.9%). Using Multinomial Logistic Regression and considering the odds ratio, our results indicated that a one-point increase in sustained attention, visual memory, and working memory might decrease the odds of being categorized in the severe group by 20%, 24%, and 77%, respectively, compared to the mild group.Conclusions Our findings provide empirical evidence regarding the long-term cognitive effects of COVID-19, particularly in individuals experiencing severe manifestations of the disease. We also highlighted the need for a comprehensive, multidimensional approach in rehabilitation programs to address the enduring cognitive impacts of COVID-19.
  • article 0 Citação(ões) na Scopus
    Postorotracheal intubation dysphagia in patients with COVID-19: A retrospective study
    (2024) SACONATO, Mariana; MASELLI-SCHOUERI, Jean Henri; MALAQUE, Ceila Maria Sant'Ana; MARCUSSO, Rosa Maria; OLIVEIRA, Augusto Cesar Penalva de; BATISTA, Lucio Antonio Nascimento; ULTRAMARI, Graziela; LINDOSO, Jose Angelo Lauletta; GONCALVES, Maria Ines Rebelo; SZTAJNBOK, Jaques
    BACKGROUND: The cause of oropharyngeal dysphagia in patients with coronavirus disease (COVID-19) can be multifactorial and may underly limitations in swallowing rehabilitation. OBJECTIVE: Analyze the factors related to dysphagia in patients with COVID-19 immediately after orotracheal extubation and the factors that influence swallowing rehabilitation. DESIGN AND SETTING: A retrospective study. METHODS: The presence of dysphagia was evaluated using the American Speech-Language Hearing Association National Outcome Measurement System (ASHA NOMS) scale and variables that influenced swallowing rehabilitation in 140 adult patients who required invasive mechanical ventilation for >48 h. RESULTS: In total, 46.43% of the patients scored 1 or 2 on the ASHA NOMS (severe dysphagia) and 39.29% scored 4 (single consistency delivered orally) or 5 (exclusive oral diet with adaptations). Both the length of mechanical ventilation and the presence of neurological disorders were associated with lower ASHA NOMS scores (odds ratio [OR]: 0.80, 95% confidence interval [CI]: 0.74-0.87 P < 0.05; and OR: 0.13, 95% CI: 0.61-0.29; P < 0.05, respectively). Age and the presence of tracheostomy were negatively associated with speech rehabilitation (OR: 0.92; 95% CI: 0.87--0.96; OR: 0.24; 95% CI: 0.80--0.75), and acute post-COVID-19 kidney injury requiring dialysis and lower scores on the ASHA NOMS were associated with longer time for speech therapy outcomes ( beta : 1.62, 95% CI, 0.70-3.17, P < 0.001; beta : -1.24, 95% CI: -1.55--0.92; P < 0.001). CONCLUSION: Prolonged orotracheal intubation and post-COVID-19 neurological alterations increase the probability of dysphagia immediately after extubation. Increased age and tracheostomy limited rehabilitation.
  • article 0 Citação(ões) na Scopus
    COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
    (2024) MCDONNELL, John; COUSINS, Kimberley; YOUNGER, M. Elizabeth M.; LANE, Adam; ABOLHASSANI, Hassan; ABRAHAM, Roshini S.; AL-TAMEMI, Salem; ALDAVE-BECERRA, Juan Carlos; AL-FARIS, Eman Hesham; ALFARO-MURILLO, Alberto; ALKHATER, Suzan A.; ALSAATI, Nouf; DOSS, Alexa Michelle Altman; ANDERSON, Melissa; ANGAROLA, Ernestina; ARIUE, Barbara; ARNOLD, Danielle E.; ASSA'AD, Amal H.; AYTEKIN, Caner; BANK, Meaghan; BERGERSON, Jenna R. E.; BLEESING, Jack; BOESING, John; BOUSO, Carolina; BRODSZKI, Nicholas; CABANILLAS, Diana; CADY, Carol; CALLAHAN, Meghan A.; CAORSI, Roberta; CARBONE, Javier; CARRABBA, Maria; CASTAGNOLI, Riccardo; CATANZARO, Jason R.; CHAN, Samantha; CHANDRA, Sharat; CHAPDELAINE, Hugo; CHAVOSHZADEH, Zahra; CHONG, Hey Jin; CONNORS, Lori; CONSONNI, Filippo; CORREA-JIMENEZ, Oscar; CUNNINGHAM-RUNDLES, Charlotte; D'ASTOUS-GAUTHIER, Katherine; DELMONTE, Ottavia Maria; DEMIRDAG, Yesim Yilmaz; DESHPANDE, Deepti R.; DIAZ-CABRERA, Natalie M.; DIMITRIADES, Victoria R.; EL-OWAIDY, Rasha; ELGHAZALI, Gehad; AL-HAMMADI, Suleiman; FABIO, Giovanna; FAURE, Astrid Schellnast; FENG, Jin; FERNANDEZ, James M.; FILL, Lauren; FRANCO, Guacira R.; FRENCK, Robert W.; FULEIHAN, Ramsay L.; GIARDINO, Giuliana; GALANT-SWAFFORD, Jessica; GAMBINERI, Eleonora; GARABEDIAN, Elizabeth K.; GEERLINKS, Ashley V.; GOUDOURIS, Ekaterini; GRECCO, Octavio; PAN-HAMMARSTROM, Qiang; KHANI, Hedieh Haji Khodaverdi; HAMMARSTROM, Lennart; HARTOG, Nicholas L.; HEIMALL, Jennifer; HERNANDEZ-MOLINA, Gabriela; HORNER, Caroline C.; HOSTOFFER, Robert W.; HRISTOVA, Nataliya; HSIAO, Kuang-Chih; IVANKOVICH-ESCOTO, Gabriela; JABER, Faris; JALIL, Maaz; JAMEE, Mahnaz; JEAN, Tiffany; JEONG, Stephanie; JHAVERI, Devi; JORDAN, Michael B.; JOSHI, Avni Y.; KALKAT, Amanpreet; KANAREK, Henry J.; KELLNER, Erinn S.; KHOJAH, Amer; KHOURY, Ruby; KOKRON, Cristina M.; KUMAR, Ashish; LECERF, Kelsey; LEHMAN, Heather K.; LEIDING, Jennifer W.; LESMANA, Harry; LIM, Xin Rong; LOPES, Joao Pedro; LOPEZ, Ana Laura; TARQUINI, Lucia; LUNDGREN, Ingrid S.; MAGNUSSON, Julieann; MARINHO, Ana Karolina B. B.; MARSEGLIA, Gian Luigi; MARTONE, Giulia M.; MECHTLER, Annamaria G.; MENDONCA, Leonardo; MILNER, Joshua D.; MUSTILLO, Peter J.; NADERI, Asal Gharib; NAVIGLIO, Samuele; NELL, Jeremy; NIEBUR, Hana B.; NOTARANGELO, Luigi; OLEASTRO, Matias; ORTEGA-LOPEZ, Maria Claudia; PATEL, Neil R.; PETROVIC, Gordana; PIGNATA, Claudio; PORRAS, Oscar; PRINCE, Benjamin T.; PUCK, Jennifer M.; QAMAR, Nashmia; RABUSIN, Marco; RAJE, Nikita; REGAIRAZ, Lorena; RISMA, Kimberly A.; RISTAGNO, Elizabeth H.; ROUTES, John; ROXO-JUNIOR, Persio; SALEMI, Negin; SCALCHUNES, Christopher; SCHUVAL, Susan J.; SENEVIRATNE, Suranjith L.; SHANKAR, Ashwin; SHERKAT, Roya; SHIN, Junghee Jenny; SIDDIQI, Abeer; SIGNA, Sara; SOBH, Ali; LIMA, Fabiana Mascarenhas Souza; STENEHJEM, Kristen K.; TAM, Jonathan S.; TANG, Monica; BARROS, Myrthes Toledo; VERBSKY, James; VERGADI, Eleni; VOELKER, Dayne H.; VOLPI, Stefano; WALL, Luke A.; WANG, Christine; WILLIAMS, Kelli W.; WU, Eveline Y.; WU, Shan Shan; ZHOU, Jessie J.; COOK, Alexandria; SULLIVAN, Kathleen E.; MARSH, Rebecca
    Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. Objective To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. Methods We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. Results Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. Conclusion Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.
  • article
    Inequality on the frontline: A multi-country study on gender differences in mental health among healthcare workers during the COVID-19 pandemic
    (2024) CZEPIEL, Diana; MCCORMACK, Clare; SILVA, Andrea T. C. da; SEBLOVA, Dominika; MORO, Maria F.; RESTREPO-HENAO, Alexandra; MARTINEZ, Adriana M.; AFOLABI, Oyeyemi; ALNASSER, Lubna; ALVARADO, Ruben; ASAOKA, Hiroki; AYINDE, Olatunde; BALALIAN, Arin; BALLESTER, Dinarte; BARATHIE, Josleen A. l.; BASAGOITIA, Armando; BASIC, Djordje; BURRONE, Maria S.; CARTA, Mauro G.; DURAND-ARIAS, Sol; ESKIN, Mehmet; FERNANDEZ-JIMENEZ, Eduardo; FREY, Marcela I. F.; GUREJE, Oye; ISAHAKYAN, Anna; JALDO, Rodrigo; KARAM, Elie G.; KHATTECH, Dorra; LINDERT, Jutta; MARTINEZ-ALES, Gonzalo; MASCAYANO, Franco; MEDIAVILLA, Roberto; GONZALEZ, Javier A. Narvaez; NASSER-KARAM, Aimee; NISHI, Daisuke; OLAOPA, Olusegun; OUALI, Uta; PUAC-POLANCO, Victor; RAMIREZ, Dorian E.; RAMIREZ, Jorge; RIVERA-SEGARRA, Eliut; RUTTEN, Bart P. F.; SANTAELLA-TENORIO, Julian; SAPAG, Jaime C.; SEBLOVA, Jana; SOTO, Maria T. S.; TAVARES-CAVALCANTI, Maria; VALERI, Linda; SIJBRANDIJ, Marit; SUSSER, Ezra S.; HOEK, Hans W.; VEN, Els van der
    Healthcare workers (HCWs) were at increased risk for mental health problems during the COVID-19 pandemic, with prior data suggesting women may be particularly vulnerable. Our global mental health study aimed to examine factors associated with gender differences in psychological distress and depressive symptoms among HCWs during COVID-19. Across 22 countries in South America, Europe, Asia and Africa, 32,410 HCWs participated in the COVID-19 HEalth caRe wOrkErS (HEROES) study between March 2020 and February 2021. They completed the General Health Questionnaire-12, the Patient Health Questionnaire-9 and questions about pandemic-relevant exposures. Consistently across countries, women reported elevated mental health problems compared to men. Women also reported increased COVID-19-relevant stressors, including insufficient personal protective equipment and less support from colleagues, while men reported increased contact with COVID-19 patients. At the country level, HCWs in countries with higher gender inequality reported less mental health problems. Higher COVID-19 mortality rates were associated with increased psychological distress merely among women. Our findings suggest that among HCWs, women may have been disproportionately exposed to COVID-19-relevant stressors at the individual and country level. This highlights the importance of considering gender in emergency response efforts to safeguard women's well-being and ensure healthcare system preparedness during future public health crises.
  • article 0 Citação(ões) na Scopus
    Differential Diagnosis in the Management of Acute Respiratory Infections through Point-of-Care Rapid Testing in a Post-Pandemic Scenario in Latin America: Special Focus on COVID-19, Influenza, and Respiratory Syncytial Virus
    (2024) ALVAREZ-MORENO, Carlos Arturo; ARAUJO, Evaldo Stanislau Affonso de; BAUMEISTER, Elsa; CRESPO, Katya A. Nogales; KALERGIS, Alexis M.; MEDINA, Jose Esteban Munoz; TSUKAYAMA, Pablo; UGARTE-GIL, Cesar
    This review provides a comprehensive summary of evidence to explore the role and value of differential diagnosis in the management of Acute Respiratory Infections (ARIs) through point-of-care (POC) rapid testing in a post-pandemic scenario, paying particular attention to coronavirus disease 2019 (COVID-19), influenza, and respiratory syncytial virus (RSV). The document builds on a review of literature and policies and a process of validation and feedback by a group of seven experts from Latin America (LATAM). Evidence was collected to understand scientific and policy perspectives on the differential diagnosis of ARIs and POC rapid testing, with a focus on seven countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru. The evidence indicates that POC rapid testing can serve to improve ARI case management, epidemiological surveillance, research and innovation, and evidence-based decision-making. With multiple types of rapid tests available for POC, decisions regarding which tests to use require the consideration of the testing purpose, available resources, and test characteristics regarding accuracy, accessibility, affordability, and results turnaround time. Based on the understanding of the current situation, this document provides a set of recommendations for the implementation of POC rapid testing in LATAM, supporting decision-making and guiding efforts by a broad range of stakeholders.
  • article 0 Citação(ões) na Scopus
    Feasibility, safety, and adherence of a remote physical and cognitive exercise protocol for older women
    (2024) PEIXOTO, Cristiane; MATIOLI, Maria Niures Pimentel dos Santos; TAKANO, Satiko Andrezza Ferreira; TEIXEIRA, Mauricio Silva; NETO, Carlos Eduardo Borges Passos; BRUCKI, Sonia Maria Dozzi
    Background Population aging and the consequences of social distancing after the COVID-19 pandemic make it relevant to investigate the feasibility of remote interventions and their potential effects on averting functional decline. Objective (1) To investigate the feasibility, safety, and adherence of a remote protocol involving physical and cognitive exercises for older women with normal cognition; (2) to examine its effects on cognitive and well-being variables. Methods Twenty-nine women (age >= 60 years old) were randomized into experimental group (EG; n = 15) and control group (CG; n = 14). The EG performed a 40-minute session of cognitive and physical exercises, and CG performed a 20-minute stretching session. Both groups performed 20 sessions via videoconference and 20 on YouTube twice a week. The Mini-Mental State Examination, Verbal Fluency Test, Digit Span (direct an inverse order), Geriatric Depression Scale (GDS), and Well-being Index (WHO-5) were applied in pre- and post-interventions by phone. Results Overall adherence was 82.25% in EG and 74.29% in CG. The occurrence of adverse events (mild muscle pain) was 33.3% in EG and 21.4% in CG. The EG improved verbal fluency and attention ( p <= 0.05); both groups had improved depressive symptoms. Conclusion The present study met the pre-established criteria for feasibility, safety, and adherence to the remote exercise protocol among older women. The results suggest that a combined protocol has more significant potential to improve cognitive function. Both interventions were beneficial in improving the subjective perception of well-being.
  • article 1 Citação(ões) na Scopus
    Cross-cultural measurement invariance of the pandemic fatigue scale (PFS) in five South American countries
    This study evaluated the cross-cultural measurement invariance of the Pandemic Fatigue Scale (PFS) in five South American countries, Argentina, Bolivia, Paraguay, Peru, and Uruguay. A total of 1448 people selected through convenience sampling (295 Argentines, 294 Bolivians, 279 Uruguayans, 277 Peruvians, and 303 Paraguayans) participated. The two-dimensional structure of the PFS fitted well with the data from each country. Invariance analysis showed that PFS was completely invariant across countries, thus providing a solid basis for comparisons between groups. Adequate discrimination and difficulty were reported for all items. Adequate discrimination parameters would indicate that the PFS items would allow people to differentiate the choice of response alternatives based on the presence of PF. In addition, the difficulty parameters indicate that people require a greater presence of the latent trait to respond to the higher response alternatives of PFS. It was also observed that the boredom and neglect dimensions have a significant and negative impact on protective behaviors, providing evidence of validity based on their relationship with other constructs. In conclusion, the PFS presents evidence of validity and MI for the measurement of PF in the five South American countries included in this study. Thus, PFS can contribute to future empirical research that compares FP in different South American populations and cultures.
  • article 7 Citação(ões) na Scopus
    Benefits of probiotic use on COVID-19: A systematic review and meta-analysis
    (2024) VIANA, Suelen Neris Almeida; PEREIRA, Tamires do Reis Santos; ALVES, Janaina de Carvalho; CASTRO, Caroline Tianeze de; SILVA, Lucas Santana C. da; PINHEIRO, Lucio Henrique Sousa; ROSELINO, Mariana Nougalli
    SARS-CoV-2 is the virus that causes the new global pandemic, which has already resulted in millions of deaths, affecting the world's health and economy. Probiotics have shown benefits in a variety of diseases, including respiratory infections, and may be beneficial in the adjunctive treatment of COVID-19. This study analyzed the effectiveness of probiotics as adjunctive treatment in reducing symptoms of patients with COVID-19, through a systematic review with meta-analysis. The EMBASE (Elsevier), Pubmed, Scopus, Web of Science and International Clinical Trials Registry Platform (ICTRP) were searched through March 16, 2022. The risk ratio (RR) with 95% confidence intervals (CIs) was estimated using a fixed-effect model. RoB 2 and ROBINS I were used to assess the risk of bias of the included studies. Nine studies were included (7 clinical trials and 2 cohorts), of which three clinical trials comprised the meta-analysis. Results showed that probiotics were associated with a significant 51% reduction in symptoms reported by COVID-19 patients (RR 0.49, 95% CI 0.40-0.61). There was a significant improvement in cough (RR 0.56, 95% CI 0.37-0.83), headaches (RR 0.17, 95% CI 0.05-0.65), and diarrhea (RR 0. 33, 95% CI 0.12-0.96) of patients on probiotic therapy. These findings suggest that probiotic supplementation is effective in improving symptoms of COVID-19.
  • article
    Renal infarction secondary to Aspergillus spp. embolism following COVID-19
    (2024) NEVES, Precil Diego Miranda de Menezes; MOHRBACHER, Sara; VASQUES, Igor Lobato; CAVALCANTE, Livia Barreira; SATO, Victor Augusto Hamamoto; OLIVEIRA, Erico de Souza; PEREIRA, Leonardo Victor Barbosa; BALES, Alessandra Martins; FREDIANI, Marcella Martins; CHOCAIR-NETO, Pedro Renato; CUVELLO-NETO, Americo Lourenco
  • article 0 Citação(ões) na Scopus
    (2024) ANDRADE, Rodrigo Mantelatto; SANTANA, Bruna Gomes; SCHMIDT, Ariane Verttu; BARSOTTI, Carlos Eduardo; BARONI, Marina Pegoraro; SARAGIOTTO, Bruno Tirotti; RIBEIRO, Ana Paula
    Background: Telerehabilitation has become increasingly popular since the SARS-CoV-2 (COVID19) outbreak. However, studies are needed to understand the effects of remote delivery of spine treatment approaches. Objectives: To verify and compare the effects of traditional rehabilitation programmes (in -person) and telerehabilitation (online) on the progression of scoliotic curvature in adolescents with idiopathic scoliosis during the COVID-19 pandemic, and to verify the acceptability, appropriateness, and feasibility among patients and physiotherapists regarding both treatments. Methods: This is a cohort study (prospective analysis of 2 intervention groups: telerehabilitation (online) and traditional rehabilitation (in -person). A total of 66 adolescents with idiopathic scoliosis were included. Recruitment was conducted through the Clinical Center in Scoliosis Care (January-December 2020). Participants were divided into 2 intervention groups: telerehabilitation (online) (n = 33) and traditional rehabilitation programme (in -person) (n = 33). Both groups also were supplied with a spinal orthopaedic brace. Scoliosis was confirmed by a spine X-ray examination (Cobb angle). Radiographic parameters measured were: Cobb angles (thoracic and lumbar). The method of Nash and Moe (thoracic and lumbar) was also evaluated based on the relationship between the vertebral pedicles and the centre of the vertebral body in the X-rays. Assessments were performed at baseline (T0) and after 6 months of the intervention protocol (T6). Patient and physiotherapist reports were evaluated on the acceptability, appropriateness, and feasibility of the interventions. Results: Adolescents with idiopathic scoliosis showed a significant decrease in the Cobb angle (main scoliotic curvature), with a 4.9 degrees for the traditional rehabilitation programme and 2.4 degrees for the telerehabilitation. Thoracic and lumbar Cobb angles did not show significant changes after the intervention in both groups or between groups. Thoracic and lumbar Nash and Moe scores scores also did not show significant differences after 6 months of in -person or telerehabilitation intervention, or between groups. The intervention by telerehabilitation was acceptable, appropriate, and feasible for patients and physiotherapists. Conclusion: Use of the rehabilitation programme for adolescents with idiopathic scoliosis, delivered via telerehabilitation during the COVID-19 pandemic, was encouraging for future applications due to the improved effect on reducing the Cobb angle, preventing progression of scoliosis. In addition, telerehabilitation showed good acceptability among patients and physiotherapists. Traditional rehabilitation programmes (in -person) in adolescents with idiopathic scoliosis also showed a reduction in the Cobb angle.
  • article 0 Citação(ões) na Scopus
    The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19 A Multicenter Cohort Study of 35,619 Critically Ill Patients
    (2024) BASTOS, Leonardo S. L.; HAMACHER, Silvio; KURTZ, Pedro; RANZANI, Otavio T.; ZAMPIERI, Fernando G.; SOARES, Marcio; BOZZA, Fernando A.; SALLUH, Jorge I. F.
    BACKGROUND: During the COVID-19 pandemic, ICUs remained under stress and observed elevated mortality rates and high variations of outcomes. A knowledge gap exists regarding whether an ICU performing best during nonpandemic times would still perform better when under high pressure compared with the least performing ICUs. RESEARCH QUESTION: Does prepandemic ICU performance explain the risk-adjusted mortality variability for critically ill patients with COVID-19? STUDY DESIGN AND METHODS: This study examined a cohort of adults with real-time polymerase chain reaction-confirmed COVID-19 admitted to 156 ICUs in 35 hospitals from February 16, 2020, through December 31, 2021, in Brazil. We evaluated crude and adjusted in-hospital mortality variability of patients with COVID-19 in the ICU during the pandemic. Association of baseline (prepandemic) ICU performance and in-hospital mortality was examined using a variable life-adjusted display (VLAD) during the pandemic and a multivariable mixed regression model adjusted by clinical characteristics, interaction of performance with the year of admission, and mechanical ventilation at admission. RESULTS: Thirty-five thousand six hundred nineteen patients with confirmed COVID-19 were evaluated. The median age was 52 years, median Simplified Acute Physiology Score 3 was 42, and 18% underwent invasive mechanical ventilation. In-hospital mortality was 13% and 54% for those receiving invasive mechanical ventilation. Adjusted in-hospital mortality ranged from 3.6% to 63.2%. VLAD in the most efficient ICUs was higher than the overall median in 18% of weeks, whereas VLAD was 62% and 84% in the underachieving and least efficient groups, respectively. The least efficient baseline ICU performance group was associated independently with increased mortality (OR, 2.30; 95% CI, 1.45-3.62) after adjusting for patient characteristics, disease severity, and pandemic surge. INTERPRETATION: ICUs caring for patients with COVID-19 presented substantial variation in reduced mortality and less variability. Our findings suggest that achieving ICU efficiency by targeting improvement in organizational aspects of ICUs may impact outcomes, and therefore should be a part of the preparedness for future pandemics.
  • article 0 Citação(ões) na Scopus
    Enhanced Immunogenicity and Protective Effects against SARS-CoV-2 Following Immunization with a Recombinant RBD-IgG Chimeric Protein
    (2024) SILVA, Mariangela de Oliveira; CASTRO-AMARANTE, Maria Fernanda; VENCESLAU-CARVALHO, Alexia Adrianne; ALMEIDA, Bianca da Silva; DAHER, Isabela Pazotti; SOUZA-SILVA, Guilherme Antonio de; YAMAMOTO, Marcio Massao; KOIKE, Gabriela; SOUZA, Edmarcia Elisa de; WRENGER, Carsten; FERREIRA, Luis Carlos de Souza; BOSCARDIN, Silvia Beatriz
    The unprecedented global impact caused by SARS-CoV-2 imposed huge health and economic challenges, highlighting the urgent need for safe and effective vaccines. The receptor-binding domain (RBD) of SARS-CoV-2 is the major target for neutralizing antibodies and for vaccine formulations. Nonetheless, the low immunogenicity of the RBD requires the use of alternative strategies to enhance its immunological properties. Here, we evaluated the use of a subunit vaccine antigen generated after the genetic fusing of the RBD with a mouse IgG antibody. Subcutaneous administration of RBD-IgG led to the extended presence of the protein in the blood of immunized animals and enhanced RBD-specific IgG titers. Furthermore, RBD-IgG immunized mice elicited increased virus neutralizing antibody titers, measured both with pseudoviruses and with live original (Wuhan) SARS-CoV-2. Immunized K18-hACE2 mice were fully resistant to the lethal challenge of the Wuhan SARS-CoV-2, demonstrated by the control of body-weight loss and virus loads in their lungs and brains. Thus, we conclude that the genetic fusion of the RBD with an IgG molecule enhanced the immunogenicity of the antigen and the generation of virus-neutralizing antibodies, supporting the use of IgG chimeric antigens as an approach to improve the performance of SARS-CoV-2 subunit vaccines.
  • article 0 Citação(ões) na Scopus
    Long-term outcomes for epidemic viral pneumonia survivors after discharge from the intensive care unit: a systematic review
    (2024) LAPORTE, Larrie Rabelo; CHAVEZ, Alexandre von Flach Garcia; RANZANI, Otavio Tavares; CALDAS, Juliana; PASSOS, Rogerio da Hora; RAMOS, Joao Gabriel Rosa
    Objective: To review the long-term outcomes (functional status and psychological sequelae) of survivors of critical illnesses due to epidemic viral pneumonia before the COVID-19 pandemic and to establish a benchmark for comparison of the COVID-19 long-term outcomes. Methods: This systematic review of clinical studies reported the long-term outcomes in adults admitted to intensive care units who were diagnosed with viral epidemic pneumonia. An electronic search was performed using databases: MEDLINE (R), Web of ScienceTM, LILACS/IBECS, and EMBASE. Additionally, complementary searches were conducted on the reference lists of eligible studies. The quality of the studies was assessed using the Newcastle-Ottawa Scale. The results were grouped into tables and textual descriptions. Results: The final analysis included 15 studies from a total of 243 studies. This review included 771 patients with Influenza A, Middle East Respiratory Syndrome, and Severe Acute Respiratory Syndrome. It analyzed the quality of life, functionality, lung function, mortality, rate of return to work, rehospitalization, and psychiatric symptoms. The follow-up periods ranged from 1 to 144 months. We found that the quality of life, functional capacity, and pulmonary function were below expected standards. Conclusion: This review revealed great heterogeneity between studies attributed to different scales, follow-up time points, and methodologies. However, this systematic review identified negative long-term effects term effects of viral pneumonia outbreaks. This review was not funded.
  • article 1 Citação(ões) na Scopus
    An electrochemical genomagnetic assay for detection of SARS-CoV-2 and Influenza A viruses in saliva
    (2024) SANTOS, Daniel Junior Almeida dos; OLIVEIRA, Tassia Regina de; ARAUJO, Gabriela Martins de; POTT-JUNIOR, Henrique; MELENDEZ, Matias Eliseo; SABINO, Ester Cerdeira; LEITE, Oldair Donizeti; FARIA, Ronaldo Censi
    Viral respiratory infections represent a major threat to the population's health globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 disease and in some cases the symptoms can be confused with Influenza disease caused by the Influenza A viruses. A simple, fast, and selective assay capable of identifying the etiological agent and differentiating the diseases is essential to provide the correct clinical management to the patient. Herein, we described the development of a genomagnetic assay for the selective capture of viral RNA from SARS-CoV-2 and Influenza A viruses in saliva samples and employing a simple disposable electrochemical device for gene detection and quantification. The proposed method showed excellent performance detecting RNA of SARS-CoV-2 and Influenza A viruses, with a limit of detection (LoD) and limit of quantification (LoQ) of 5.0 fmol L-1 and 8.6 fmol L-1 for SARS-CoV-2, and 1.0 fmol L-1 and 108.9 fmol L-1 for Influenza, respectively. The genomagnetic assay was employed to evaluate the presence of the viruses in 36 saliva samples and the results presented similar responses to those obtained by the real-time reverse transcription-polymerase chain reaction (RT-PCR), demonstrating the reliability and capability of a method as an alternative for the diagnosis of COVID-19 and Influenza with point-of-care capabilities.
  • article 1 Citação(ões) na Scopus
    Adolescent Mental Health Before and During COVID-19: Longitudinal Evidence From the 2004 Pelotas Birth Cohort in Brazil
    (2024) MARUYAMA, Jessica Mayumi; TOVO-RODRIGUES, Luciana; SANTOS, Ina S.; MURRAY, Joseph; MATIJASEVICH, Alicia
    Purpose: There is great interest in examining the consequences of the COVID-19 pandemic on adolescent mental health, but most studies were conducted in high-income countries. The identification of overall effects and protective factors is essential to understand the determinants of mental wellbeing in contexts of stress. We aimed to study changes in adolescent mental health during the pandemic and the risk and protective factors associated with these changes in a Brazilian birth cohort. Methods: One thousand nine hundred forty nine adolescents from the 2004 Pelotas Birth Cohort were assessed prepandemic (T1, November 2019 to March 2020, mean age 15.69 years) and midpandemic (T2, August to December 2021, mean age 17.41 years). Mental health was assessed using the Strengths and Difficulties Questionnaire. Prepandemic and pandemic-related predictors were symptoms at T2. Higher emotion regulation levels protected against increases in adolescent mental Discussion: Family-context variables emerged as important risk factors for the deterioration of (c) 2024 Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine.
  • article 1 Citação(ões) na Scopus
    Mother-infant bonding and postpartum depression during the COVID-19 pandemic - a risk for nurturing care and child development
    (2024) DINIZ, Barbara Portela; GRISI, Sandra Josefina Ferraz Ellero; SOUZA, Danton Matheus de; FERRER, Ana Paula Scoleze
    Objective: The COVID-19 pandemic Increased the risk of impairing the mother -infant bonding. The objectives of this study were to evaluate the early bond established between mother and infant and postpartum depression (PPD) in pregnancies that occurred during the pandemic period, to identify the factors that may have influenced these outcomes and to verify if there was an association between bonding and probable PPD. Methods: This is a cross-sectional study of postpartum women from a public maternity hospital in the city of S & atilde;o Paulo conducted from February to June 2021, involving 127 mother -baby dyads. The initial data were collected in the immediate postpartum period and between 21-45 days after birth, using a semi -structured questionnaire on sociodemographic characteristics, gestational and birth conditions, and baby characteristics; the Edinburgh Postnatal Depression Scale (EPDS) and Postpartum Bonding Questionnaire (PBQ) were used to evaluate PPD and bonding, respectively. Results: The presence of probable PPD and unplanned pregnancies were associated with higher PBQ score and risk to impaired bonding (p = 0.001 and p = 0.004, respectively). EPDS showed a high prevalence of PPD (29.1%) and was not associated with any Studied variable. Probably, this high prevalence of probable PPD was due to the context of insecurity secondary to the pandemic. Conclusions: We observed an increase in the prevalence of probable PPD and unplanned pregnancies during the first 18 months of the pandemic, which were associated with worse scores in mother -infant bonding. The impaired bond can affect the future development of children born during this period.