Outer Retinal Dysfunction on Multifocal Electroretinography May Help Differentiating Multiple Sclerosis From Neuromyelitis Optica Spectrum Disorder

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFILGUEIRAS, Thiago G.
dc.contributor.authorOYAMADA, Maria K.
dc.contributor.authorPRETI, Rony C.
dc.contributor.authorAPOSTOLOS-PEREIRA, Samira L.
dc.contributor.authorCALLEGARO, Dagoberto
dc.contributor.authorMONTEIRO, Mario L. R.
dc.date.accessioned2019-09-23T14:19:03Z
dc.date.available2019-09-23T14:19:03Z
dc.date.issued2019
dc.description.abstractPurpose: To evaluate the intermediate and outer retina of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using OCT and multifocal electroretinography (mf-ERG). Methods: Patients with MS (n = 30), NMOSD (n = 30), and healthy controls (n = 29) underwent visual field (VF), OCT, and mt-ERG testing. The eyes were distributed into 5 groups: MS with or without history of ON (MS+ON, MS-ON), NMOSD with or without ON (NMOSD+ON, NMOSD-ON), and controls. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer, outer plexiform layer, outer nuclear layer, and photoreceptor layer was measured. mf-ERG P1 and N1 responses were registered and grouped in 3 sets of rings. The groups were compared using GEE models, and effect size (ES) calculated. Results: Compared to controls, GCL and IPL thickness was significantly smaller in MS+ON (both p < 0.01), MS-ON (p < 0.01 and p = 0.015, respectively), NMOSD+ON (both p < 0.01) and NMOSD-ON (p = 0.03 and p = 0.018, respectively). ES was >0.80. mRNFL was smaller in three of the above groups (p < 0.01, p < 0.001, and p = 0.028; ES > 0.80) but not in MS-ON eyes (p = 0.18). No significant difference was observed for the remaining layers. Compared to controls, P1 and N1 peak times were shorter in MS (p-values in the range 0.049-0.002, ES < 0.50; and 0.049-0.010; ES < 0.50, respectively) but not in NMOSD. These abnormalities were strongly correlated with intermediate and outer retinal layer thickness. Conclusions: mf-ERG data suggest outer retinal abnormalities in MS, but not in NMOSD. Our results may help understand how the two conditions differ regarding retinal damage.eng
dc.description.indexPubMedeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/26585-5]
dc.description.sponsorshipCAPES-Coordenacao de Aperfeicoamento de Nivel Superior, Brasilia, Brazil
dc.description.sponsorshipCNPq-Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [307393/2014-3]
dc.identifier.citationFRONTIERS IN NEUROLOGY, v.10, article ID 928, 11p, 2019
dc.identifier.doi10.3389/fneur.2019.00928
dc.identifier.issn1664-2295
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33518
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Neurology
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectmultiple sclerosiseng
dc.subjectneuromyelitis opticaeng
dc.subjectelectroretinogrameng
dc.subjectoptical coherence tomographyeng
dc.subjectretinal layerseng
dc.subject.otherdiagnostic-criteriaeng
dc.subject.othercoherence tomographyeng
dc.subject.otherabnormalitieseng
dc.subject.otherpathologyeng
dc.subject.otherneuritiseng
dc.subject.otherdiseaseeng
dc.subject.otherhyperglycemiaeng
dc.subject.otherglutamateeng
dc.subject.otheratrophyeng
dc.subject.otherocteng
dc.subject.wosClinical Neurologyeng
dc.subject.wosNeuroscienceseng
dc.titleOuter Retinal Dysfunction on Multifocal Electroretinography May Help Differentiating Multiple Sclerosis From Neuromyelitis Optica Spectrum Disordereng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcTHIAGO GOMES FILGUEIRAS
hcfmusp.contributor.author-fmusphcMARIA KIYOKO OYAMADA
hcfmusp.contributor.author-fmusphcRONY CARLOS PRETI
hcfmusp.contributor.author-fmusphcSAMIRA LUISA DOS APOSTOLOS PEREIRA
hcfmusp.contributor.author-fmusphcDAGOBERTO CALLEGARO
hcfmusp.contributor.author-fmusphcMARIO LUIZ RIBEIRO MONTEIRO
hcfmusp.description.articlenumber928
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed31507527
hcfmusp.origem.scopus2-s2.0-85071724307
hcfmusp.origem.wosWOS:000482824200003
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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