Cardiologic Manifestation in Amyloidosis

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bookPart
Data de publicação
2023
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SPRINGER INTERNATIONAL PUBLISHING
Citação
de Alencar Neto, A. C.; Cafezeiro, C. R. F.; Bueno, B. V. K.; de Carvalho Singulane, C.; Fernandes, F.. Cardiologic Manifestation in Amyloidosis. In: . Amyloidosis and Fabry Disease: a Clinical Guide: SPRINGER INTERNATIONAL PUBLISHING, 2023. p.43-48.
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Resumo
ATTR and AL amyloidosis are responsible for approximately 95% of all cases of CA. Cardiac amyloidosis (CA) is a relatively common cause of heart failure with preserved ejection fraction (HFpEF). It is important to know that extracardiac changes may precede cardiac involvement by a few years; thus, it is essential to recognize these findings as part of the clinical feature in a patient with amyloidosis. CA results from the progressive deposition of amyloid fibrils in the extracellular space. The involvement of amyloidosis includes mechanical and electrical manifestations. The most frequent CA clinical presentation is HFpEF with a restrictive pattern leading to diastolic dysfunction, followed by systolic dysfunction. Conduction disorders and arrhythmias are commonly associated. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.
Palavras-chave
Arrhythmias, Cardiac amyloidosis, Cardiac manifestations, Heart failure, Preserved ejection fraction
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