Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNEELAND, Ian J.
dc.contributor.authorROSS, Robert
dc.contributor.authorDESPRES, Jean-Pierre
dc.contributor.authorMATSUZAWA, Yuji
dc.contributor.authorYAMASHITA, Shizuya
dc.contributor.authorSHAI, Iris
dc.contributor.authorSEIDELL, Jaap
dc.contributor.authorMAGNI, Paolo
dc.contributor.authorSANTOS, Raul D.
dc.contributor.authorARSENAULT, Benoit
dc.contributor.authorCUEVAS, Ada
dc.contributor.authorHU, Frank B.
dc.contributor.authorGRIFFIN, Bruce
dc.contributor.authorZAINBON, Alberto
dc.contributor.authorBARTER, Philip
dc.contributor.authorFRUCHART, Jean-Charles
dc.contributor.authorECKEL, Robert H.
dc.contributor.groupauthorInt Atherosclerosis Soc
dc.contributor.groupauthorInt Chair Cardiometab Risk Working
dc.date.accessioned2019-09-23T14:15:57Z
dc.date.available2019-09-23T14:15:57Z
dc.date.issued2019
dc.description.abstractFindings from epidemiological studies over the past 30 years have shown that visceral adipose tissue, accurately measured by CT or MRI, is an independent risk marker of cardiovascular and metabolic morbidity and mortality. Emerging evidence also suggests that ectopic fat deposition, including hepatic and epicardial fat, might contribute to increased atherosclerosis and cardiometabolic risk. This joint position statement from the International Atherosclerosis Society and the International Chair on Cardiometabolic Risk Working Group on Visceral Obesity summarises the evidence for visceral adiposity and ectopic fat as emerging risk factors for type 2 diabetes, atherosclerosis, and cardiovascular disease, with a focus on practical recommendations for health professionals and future directions for research and clinical practice. We discuss the measurement of visceral and ectopic fat, pathophysiology and contribution to adverse health outcomes, response to treatment, and lessons from a public health programme targeting visceral and ectopic fat. We identify knowledge gaps and note the need to develop simple, clinically applicable tools to be able to monitor changes in visceral and ectopic fat over time. Finally, we recognise the need for public health messaging to focus on visceral and ectopic fat in addition to excess bodyweight to better combat the growing epidemic of obesity worldwide.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipInternational Atherosclerosis Society (IAS)
dc.identifier.citationLANCET DIABETES & ENDOCRINOLOGY, v.7, n.9, p.715-725, 2019
dc.identifier.doi10.1016/S2213-8587(19)30084-1
dc.identifier.issn2213-8587
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33434
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofLancet Diabetes & Endocrinology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subject.othermetabolically healthy obesityeng
dc.subject.othersubcutaneous adipose-tissueeng
dc.subject.otherx-ray absorptiometryeng
dc.subject.otherabdominal fateng
dc.subject.otherphysical-activityeng
dc.subject.otherweight-losseng
dc.subject.otherwaist circumferenceeng
dc.subject.otherinsulin-resistanceeng
dc.subject.otherliver-diseaseeng
dc.subject.otherbody-fateng
dc.subject.wosEndocrinology & Metabolismeng
dc.titleVisceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statementeng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryIsrael
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryChile
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisoil
hcfmusp.affiliation.countryisonl
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisocl
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisoau
hcfmusp.affiliation.countryisofr
hcfmusp.author.externalNEELAND, Ian J.:Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX 75390 USA
hcfmusp.author.externalROSS, Robert:Queens Univ, Sch Med, Div Endocrinol & Metab, Kingston, ON, Canada
hcfmusp.author.externalDESPRES, Jean-Pierre:Quebec Heartand Lung Inst Res Ctr, Quebec City, PQ, Canada; Univ Laval, Fac Med, Dept Kinesiol, Quebec City, PQ, Canada
hcfmusp.author.externalMATSUZAWA, Yuji:Sumitomo Hosp, Dept Endocrinol & Metab, Osaka, Japan
hcfmusp.author.externalYAMASHITA, Shizuya:Osaka Univ, Grad Sch Med, Dept Cardiovasc Med, Osaka, Japan; Osaka Univ, Grad Sch Med, Dept Community Med, Osaka, Japan
hcfmusp.author.externalSHAI, Iris:Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel
hcfmusp.author.externalSEIDELL, Jaap:Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam, Netherlands; Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands
hcfmusp.author.externalMAGNI, Paolo:Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy
hcfmusp.author.externalARSENAULT, Benoit:Quebec Heartand Lung Inst Res Ctr, Quebec City, PQ, Canada; Univ Laval, Fac Med, Dept Med, Quebec City, PQ, Canada
hcfmusp.author.externalCUEVAS, Ada:Clin Las Condes, Dept Clin Nutr & Metab, Santiago, Chile
hcfmusp.author.externalHU, Frank B.:Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
hcfmusp.author.externalGRIFFIN, Bruce:Univ Surrey, Dept Nutr Sci, Guildford, Surrey, England
hcfmusp.author.externalZAINBON, Alberto:Univ Padua, Dept Med, Padua, Italy
hcfmusp.author.externalBARTER, Philip:Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
hcfmusp.author.externalFRUCHART, Jean-Charles:Fdn Coeur & Arteres, Lille, France
hcfmusp.author.externalECKEL, Robert H.:Univ Colorado, Sch Med, Div Endocrinol Metab & Diabet, Aurora, CO USA
hcfmusp.citation.scopus683
hcfmusp.contributor.author-fmusphcRAUL DIAS DOS SANTOS FILHO
hcfmusp.description.beginpage715
hcfmusp.description.endpage725
hcfmusp.description.issue9
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.pubmed31301983
hcfmusp.origem.scopus2-s2.0-85070929049
hcfmusp.origem.wosWOS:000482132700022
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceABATE N, 1995, J CLIN INVEST, V96, P88, DOI 10.1172/JCI118083eng
hcfmusp.relation.referenceAdiels M, 2008, ARTERIOSCL THROM VAS, V28, P1225, DOI 10.1161/ATVBAHA.107.160192eng
hcfmusp.relation.referenceAlberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8eng
hcfmusp.relation.referenceArita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255eng
hcfmusp.relation.referenceArsenault BJ, 2012, ANN MED, V44, P758, DOI 10.3109/07853890.2011.605387eng
hcfmusp.relation.referenceASHWELL M, 1985, BRIT MED J, V290, P1692, DOI 10.1136/bmj.290.6483.1692eng
hcfmusp.relation.referenceBatetta B, 2009, J NUTR, V139, P1495, DOI 10.3945/jn.109.104844eng
hcfmusp.relation.referenceBays HE, 2011, J AM COLL CARDIOL, V57, P2461, DOI 10.1016/j.jacc.2011.02.038eng
hcfmusp.relation.referenceBays HE, 2019, OBESITY ALGORITHM SLeng
hcfmusp.relation.referenceBenjamin EJ, 2018, CIRCULATION, V137, pE67, DOI 10.1161/CIR.0000000000000558eng
hcfmusp.relation.referenceBORKAN GA, 1982, AM J CLIN NUTR, V36, P172eng
hcfmusp.relation.referenceBrauer P, 2015, CAN MED ASSOC J, V187, P184, DOI 10.1503/cmaj.140887eng
hcfmusp.relation.referenceBritton KA, 2011, CIRCULATION, V124, pE837, DOI 10.1161/CIRCULATIONAHA.111.077602eng
hcfmusp.relation.referenceBrochu M, 2009, J CLIN ENDOCR METAB, V94, P3226, DOI 10.1210/jc.2008-2706eng
hcfmusp.relation.referenceChaston TB, 2008, INT J OBESITY, V32, P619, DOI 10.1038/sj.ijo.0803761eng
hcfmusp.relation.referenceCowan TE, 2018, OBESITY, V26, P1696, DOI 10.1002/oby.22304eng
hcfmusp.relation.referenceCuthbertson DJ, 2017, INT J OBESITY, V41, P853, DOI 10.1038/ijo.2017.4eng
hcfmusp.relation.referenceDespres JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228eng
hcfmusp.relation.referenceDespres JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488eng
hcfmusp.relation.referenceDespres JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264eng
hcfmusp.relation.referenceDespres JP, 2012, J CLIN ENDOCR METAB, V97, P2283, DOI 10.1210/jc.2012-2081eng
hcfmusp.relation.referenceDESPRES JP, 1989, DIABETES, V38, P304, DOI 10.2337/diabetes.38.3.304eng
hcfmusp.relation.referenceDESPRES JP, 1990, ARTERIOSCLEROSIS, V10, P497, DOI 10.1161/01.ATV.10.4.497eng
hcfmusp.relation.referenceDongiovanni P, 2015, HEPATOLOGY, V61, P506, DOI 10.1002/hep.27490eng
hcfmusp.relation.referenceEslam M, 2018, J HEPATOL, V68, P268, DOI 10.1016/j.jhep.2017.09.003eng
hcfmusp.relation.referenceFabbrini E, 2009, P NATL ACAD SCI USA, V106, P15430, DOI 10.1073/pnas.0904944106eng
hcfmusp.relation.referenceFox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355eng
hcfmusp.relation.referenceFUJIOKA S, 1987, METABOLISM, V36, P54, DOI 10.1016/0026-0495(87)90063-1eng
hcfmusp.relation.referenceGarvey WT, 2016, ENDOCR PRACT, V22, P1, DOI 10.4158/EP161365.GLeng
hcfmusp.relation.referenceGasteyger C, 2009, DIABETES OBES METAB, V11, P596, DOI 10.1111/j.1463-1326.2008.01025.xeng
hcfmusp.relation.referenceGBD, 2015, NEW ENGL J MED, V377, P13, DOI [10.1056/NEJMoa1614362, DOI 10.1056/NEJMOA1614362]eng
hcfmusp.relation.referenceGepner Y, 2018, CIRCULATION, V137, P1143, DOI 10.1161/CIRCULATIONAHA.117.030501eng
hcfmusp.relation.referenceGonzalez-Muniesa P, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.34eng
hcfmusp.relation.referenceGradmark AMI, 2010, BRIT J NUTR, V104, P582, DOI 10.1017/S0007114510000796eng
hcfmusp.relation.referenceGrundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404eng
hcfmusp.relation.referenceHammond BP, 2017, BODY COMPOSITION: HEALTH AND PERFORMANCE IN EXERCISE AND SPORT, P109eng
hcfmusp.relation.referenceHeymsfield SB, 2015, P NUTR SOC, V74, P355, DOI 10.1017/S0029665115000129eng
hcfmusp.relation.referenceHiuge-Shimizu A, 2012, ANN MED, V44, P82, DOI 10.3109/07853890.2010.526138eng
hcfmusp.relation.referenceIacobellis G, 2011, TRENDS ENDOCRIN MET, V22, P450, DOI 10.1016/j.tem.2011.07.003eng
hcfmusp.relation.referenceIrving BA, 2008, MED SCI SPORT EXER, V40, P1863, DOI 10.1249/MSS.0b013e3181801d40eng
hcfmusp.relation.referenceJaniszewski PM, 2007, APPL PHYSIOL NUTR ME, V32, P512, DOI 10.1139/H07-018eng
hcfmusp.relation.referenceJanssen I, 2002, CAN J APPL PHYSIOL, V27, P396, DOI 10.1139/h02-021eng
hcfmusp.relation.referenceJanssen I, 2001, MED SCI SPORT EXER, V33, pS5, DOI 10.1097/00005768-200105001-00027eng
hcfmusp.relation.referenceJensen MK, 2013, CIRCULATION, V127, DOI 10.1161/01.cir.0000437739.71477.eeeng
hcfmusp.relation.referenceKaul S, 2012, OBESITY, V20, P1313, DOI 10.1038/oby.2011.393eng
hcfmusp.relation.referenceKay SJ, 2006, OBES REV, V7, P183, DOI 10.1111/j.1467-789X.2006.00250.xeng
hcfmusp.relation.referenceKeating SE, 2015, J HEPATOL, V63, P174, DOI [10.1016/j.jhep.2015.03.009, 10.1016/j.jhep.2015.02.022]eng
hcfmusp.relation.referenceKishida K, 2000, J BIOL CHEM, V275, P20896, DOI 10.1074/jbc.M001119200eng
hcfmusp.relation.referenceKlein S, 2010, DIABETES CARE, V33, P1693, DOI 10.2337/dc10-0744eng
hcfmusp.relation.referenceKotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538eng
hcfmusp.relation.referenceKozlitina J, 2014, NAT GENET, V46, P352, DOI 10.1038/ng.2901eng
hcfmusp.relation.referenceKuda O, 2018, MOL ASPECTS MED, V64, P147, DOI 10.1016/j.mam.2018.01.004eng
hcfmusp.relation.referenceKuriyama H, 1998, HEPATOLOGY, V27, P557, DOI 10.1002/hep.510270233eng
hcfmusp.relation.referenceLauridsen BK, 2018, EUR HEART J, V39, P385, DOI 10.1093/eurheartj/ehx662eng
hcfmusp.relation.referenceLee JJ, 2016, J AM COLL CARDIOL, V68, P1509, DOI 10.1016/j.jacc.2016.06.067eng
hcfmusp.relation.referenceLemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179eng
hcfmusp.relation.referenceLemieux I, 2007, CAN J CARDIOL, V23, p23B, DOI 10.1016/S0828-282X(07)71007-3eng
hcfmusp.relation.referenceLinge J, 2018, OBESITY, V26, P1785, DOI 10.1002/oby.22210eng
hcfmusp.relation.referenceMahabadi AA, 2013, J AM COLL CARDIOL, V61, P1388, DOI 10.1016/j.jacc.2012.11.062eng
hcfmusp.relation.referenceMathieu P, 2014, REV ENDOCR METAB DIS, V15, P289, DOI 10.1007/s11154-014-9299-3eng
hcfmusp.relation.referenceMatsuzawa Y, 1997, DIABETES METAB REV, V13, P3, DOI 10.1002/(SICI)1099-0895(199703)13:1<3::AID-DMR178>3.0.CO;2-Neng
hcfmusp.relation.referenceMatsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922eng
hcfmusp.relation.referenceMerlotti C, 2017, INT J OBESITY, V41, P672, DOI 10.1038/ijo.2017.31eng
hcfmusp.relation.referenceMongraw-Chaffin M, 2018, J AM COLL CARDIOL, V71, P1857, DOI 10.1016/j.jacc.2018.02.055eng
hcfmusp.relation.referenceNazare JA, 2015, AM J CARDIOL, V115, P307, DOI 10.1016/j.amjcard.2014.10.039eng
hcfmusp.relation.referenceNdumele CE, 2011, ARTERIOSCL THROM VAS, V31, P1927, DOI 10.1161/ATVBAHA.111.228262eng
hcfmusp.relation.referenceNeeland IJ, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.28eng
hcfmusp.relation.referenceNeeland IJ, 2018, CIRCULATION, V137, P1391, DOI 10.1161/CIRCULATIONAHA.117.029617eng
hcfmusp.relation.referenceNeeland IJ, 2017, METABOLISM, V67, P80, DOI 10.1016/j.metabol.2016.11.008eng
hcfmusp.relation.referenceNeeland IJ, 2015, DIABETES THER, V6, P635, DOI 10.1007/s13300-015-0146-7eng
hcfmusp.relation.referenceNeeland IJ, 2013, OBESITY, V21, pE439, DOI [10.1038/oby.20135, 10.1002/oby.20135]eng
hcfmusp.relation.referenceO'Neill T, 2013, EXERCISE THERAPY ADU, P43eng
hcfmusp.relation.referenceOhkawara K, 2007, INT J OBESITY, V31, P1786, DOI 10.1038/sj.ijo.0803683eng
hcfmusp.relation.referenceOkauchi Y, 2013, J DIABETES INVEST, V4, P454, DOI 10.1111/jdi.12084eng
hcfmusp.relation.referenceOkauchi Y, 2010, ATHEROSCLEROSIS, V212, P698, DOI 10.1016/j.atherosclerosis.2010.06.011eng
hcfmusp.relation.referenceOuchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921eng
hcfmusp.relation.referencePosadas-Sanchez R., 2016, GEA STUDY IMMUNOBIOL, V222, P960eng
hcfmusp.relation.referencePOULIOT MC, 1994, AM J CARDIOL, V73, P460, DOI 10.1016/0002-9149(94)90676-9eng
hcfmusp.relation.referencePreis SR, 2010, J CLIN ENDOCR METAB, V95, P3701, DOI 10.1210/jc.2009-1779eng
hcfmusp.relation.referenceRoss R, 2004, OBES RES, V12, P789, DOI 10.1038/oby.2004.95eng
hcfmusp.relation.referenceRoss R, 2008, OBES REV, V9, P312, DOI 10.1111/j.1467-789X.2007.00411.xeng
hcfmusp.relation.referenceROSS R, 1994, AM J CLIN NUTR, V59, P1277eng
hcfmusp.relation.referenceRoss R, 2002, J CLIN ENDOCR METAB, V87, P5044, DOI 10.1210/jc.2002-020570eng
hcfmusp.relation.referenceRoss R, 2000, ANN INTERN MED, V133, P92, DOI 10.7326/0003-4819-133-2-200007180-00008eng
hcfmusp.relation.referenceROSS R, 2002, AM J PHYSIOL-ENDOC M, V282, pE65eng
hcfmusp.relation.referenceRoss R, 2015, ANN INTERN MED, V162, P325, DOI 10.7326/M14-1189eng
hcfmusp.relation.referenceRyo M, 2011, INTERNAL MED, V50, P1643, DOI 10.2169/internalmedicine.50.5039eng
hcfmusp.relation.referenceSabag A, 2017, DIABETES METAB, V43, P195, DOI 10.1016/j.diabet.2016.12.006eng
hcfmusp.relation.referenceSchauer PR, 2017, NEW ENGL J MED, V376, P641, DOI 10.1056/NEJMoa1600869eng
hcfmusp.relation.referenceSJOSTROM L, 1986, AM J PHYSIOL, V250, pE736eng
hcfmusp.relation.referenceSlentz CA, 2005, J APPL PHYSIOL, V99, P1613, DOI 10.1152/japplphysiol.00124.2005eng
hcfmusp.relation.referenceSmith U, 2016, J INTERN MED, V280, P465, DOI 10.1111/joim.12540eng
hcfmusp.relation.referenceSnijder MB, 2006, INT J EPIDEMIOL, V35, P83, DOI 10.1093/ije/dyi253eng
hcfmusp.relation.referenceTargher G, 2017, NAT REV NEPHROL, V13, P297, DOI 10.1038/nrneph.2017.16eng
hcfmusp.relation.referenceTaylor R, 2016, EXPERT REV ENDOCRINO, V11, P521, DOI 10.1080/17446651.2016.1239525eng
hcfmusp.relation.referenceTaylor R, 2015, CLIN SCI, V128, P405, DOI 10.1042/CS20140553eng
hcfmusp.relation.referenceTchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011eng
hcfmusp.relation.referenceThompson D, 2012, PHYSIOL REV, V92, P157, DOI 10.1152/physrev.00012.2011eng
hcfmusp.relation.referenceTilg H, 2017, NAT REV GASTRO HEPAT, V14, P32, DOI 10.1038/nrgastro.2016.147eng
hcfmusp.relation.referenceTOKUNAGA K, 1983, INT J OBESITY, V7, P437eng
hcfmusp.relation.referenceTsigos C, 2008, OBESITY FACTS, V1, P106, DOI 10.1159/000126822eng
hcfmusp.relation.referenceUmpleby AM, 2017, CLIN SCI, V131, P2561, DOI 10.1042/CS20171208eng
hcfmusp.relation.referenceValenti L, 2016, LIVER INT, V36, P1563, DOI 10.1111/liv.13185eng
hcfmusp.relation.referenceVasan SK, 2016, NAT REV ENDOCRINOL, V12, P375, DOI 10.1038/nrendo.2016.77eng
hcfmusp.relation.referenceVerheggen RJHM, 2016, OBES REV, V17, P664, DOI 10.1111/obr.12406eng
hcfmusp.relation.referenceVilleneuve N, 2014, APPL PHYSIOL NUTR ME, V39, P503, DOI 10.1139/apnm-2013-0270eng
hcfmusp.relation.referenceVissers D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056415eng
hcfmusp.relation.referenceWildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617eng
hcfmusp.relation.referenceWong CX, 2016, CIRC-ARRHYTHMIA ELEC, V9, DOI 10.1161/CIRCEP.116.004378eng
hcfmusp.relation.referenceYang L, 2010, CLIN ENDOCRINOL, V73, P197, DOI 10.1111/j.1365-2265.2009.03772.xeng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication342e0234-2bff-4c3b-a782-40e80d798912
relation.isAuthorOfPublication.latestForDiscovery342e0234-2bff-4c3b-a782-40e80d798912
Arquivos