Remote Ischemic Preconditioning Is Efficient in Reducing Hepatic Ischemia-Reperfusion Injury in a Growing Rat Model and Does Not Promote Histologic Lesions in Distant Organs

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOMES, P. F. M.
dc.contributor.authorTANNURI, A. C. A.
dc.contributor.authorNOGUEIRA, T. M.
dc.contributor.authorLUAMOTO, L. R.
dc.contributor.authorPAES, V. R.
dc.contributor.authorCOELHO, M. C. M.
dc.contributor.authorGONCALVES, J. O.
dc.contributor.authorSERAFINI, S.
dc.contributor.authorTANNURI, U.
dc.date.accessioned2019-02-21T17:20:49Z
dc.date.available2019-02-21T17:20:49Z
dc.date.issued2018
dc.description.abstractObjective. Ischemic preconditioning (IPC) was developed to diminish ischemia-reperfusion injury (IRI). There are two main ways of performing it: direct ischemic-preconditioning (DIP) and remote ischemic-preconditioning (RIP). The objectives of this study were to investigate local and systemic effects of DIP and RIP in liver IRI. Methods. Thirty-two weaning rats (50-70 g body weight; 21 days old) were divided into 4 groups: control (C); ischemia followed by reperfusion (IR); DIP followed by ischemia and reperfusion; and RIP followed by ischemia and reperfusion. In the IR group, the vascular pedicles of medial and left lateral liver lobes were clamped for 60 minutes and then unclamped. In the DIP group, a 10-minute cycle of ischemia followed by a 10-minute reperfusion of the same lobes was performed before 60 minutes of ischemia. In the RIP group, three 5-minute cycles of clamping and unclamping of the femoral vessels were performed before liver ischemia. The animals were euthanized 24 hours after the surgical procedures. Results. The serum levels of liver enzymes were significantly lower in the RIP group compared to the control and IR groups and to the DIP group. The scores of histologic hepatic lesions were significantly lower in RIP animals than those of IR animals (P = .002) and similar to the C group animals. The Bax/BCl-xl relation was lower in the DIP group than that in the RIP group (P = .045) and no differences were observed in histologic analyses of kidney, lung, intestine, and heart. Conclusion. In young animals, the beneficial effects of RIP are more evident than those of DIP.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de sao Paulo (FAPESP) [2016/10689-4]
dc.identifier.citationTRANSPLANTATION PROCEEDINGS, v.50, n.10, p.3840-3844, 2018
dc.identifier.doi10.1016/j.transproceed.2018.04.034
dc.identifier.eissn1873-2623
dc.identifier.issn0041-1345
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30774
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofTransplantation Proceedings
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subject.otherlivereng
dc.subject.otherpreservationeng
dc.subject.othermechanismseng
dc.subject.otherapoptosiseng
dc.subject.wosImmunologyeng
dc.subject.wosSurgeryeng
dc.subject.wosTransplantationeng
dc.titleRemote Ischemic Preconditioning Is Efficient in Reducing Hepatic Ischemia-Reperfusion Injury in a Growing Rat Model and Does Not Promote Histologic Lesions in Distant Organseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcPEDRO FILIPE MEDEIROS GOMES
hcfmusp.contributor.author-fmusphcANA CRISTINA AOUN TANNURI
hcfmusp.contributor.author-fmusphcTHIAGO MACHADO NOGUEIRA
hcfmusp.contributor.author-fmusphcVITOR RIBEIRO PAES
hcfmusp.contributor.author-fmusphcJOSIANE DE OLIVEIRA GONCALVES
hcfmusp.contributor.author-fmusphcSUELLEN SERAFINI
hcfmusp.contributor.author-fmusphcUENIS TANNURI
hcfmusp.description.beginpage3840
hcfmusp.description.endpage3844
hcfmusp.description.issue10
hcfmusp.description.volume50
hcfmusp.origemWOS
hcfmusp.origem.pubmed30385044
hcfmusp.origem.scopus2-s2.0-85055632776
hcfmusp.origem.wosWOS:000454972000149
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAnttila V, 2016, SCAND CARDIOVASC J, V50, P355, DOI 10.1080/14017431.2016.1233351eng
hcfmusp.relation.referenceBelperio JA, 2002, J CLIN INVEST, V110, P1703, DOI 10.1172/JCI200215849eng
hcfmusp.relation.referenceBertinchant JP, 2000, CLIN CHIM ACTA, V298, P13, DOI 10.1016/S0009-8981(00)00223-0eng
hcfmusp.relation.referenceCHIU CJ, 1970, ARCH SURG-CHICAGO, V101, P478eng
hcfmusp.relation.referenceCompagnon P, 2002, CRYOBIOLOGY, V44, P269, DOI 10.1016/S0011-2240(02)00033-0eng
hcfmusp.relation.referenceBraz MJD, 2018, J PEDIATR SURG, V53, P1408, DOI 10.1016/j.jpedsurg.2017.08.012eng
hcfmusp.relation.referenceFukui T, 2018, J ANESTH, V32, P3, DOI 10.1007/s00540-017-2420-5eng
hcfmusp.relation.referenceGilbo N, 2016, DIGEST LIVER DIS, V48, P1265, DOI 10.1016/j.dld.2016.06.031eng
hcfmusp.relation.referenceKanoria S, 2007, TRANSPLANTATION, V84, P445, DOI 10.1097/01.tp.0000228235.55419.e8eng
hcfmusp.relation.referenceKharbanda RK, 2002, CIRCULATION, V106, P2881, DOI 10.1161/01.CIR.0000043806.51912.9Beng
hcfmusp.relation.referenceKume M, 1996, J LAB CLIN MED, V128, P251, DOI 10.1016/S0022-2143(96)90026-8eng
hcfmusp.relation.referenceKupiec-Weglinski JW, 2005, TRANSPL P, V37, P1653, DOI 10.1016/j.transproceed.2005.03.134eng
hcfmusp.relation.referenceLee HT, 1999, J CARDIOTHOR VASC AN, V13, P78, DOI 10.1016/S1053-0770(99)90180-5eng
hcfmusp.relation.referencelenninger DD, 1994, VASCULAR SURG BASICeng
hcfmusp.relation.referenceLi DY, 2016, LIFE SCI, V150, P76, DOI 10.1016/j.lfs.2016.02.077eng
hcfmusp.relation.referenceLiu QL, 2012, LANGENBECK ARCH SURG, V397, P1323, DOI 10.1007/s00423-012-1022-9eng
hcfmusp.relation.referenceMendes-Braz M, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/298657eng
hcfmusp.relation.referencePeralta C, 1999, HEPATOLOGY, V30, P1481, DOI 10.1002/hep.510300622eng
hcfmusp.relation.referencePeralta C, 2013, J HEPATOL, V59, P1094, DOI 10.1016/j.jhep.2013.06.017eng
hcfmusp.relation.referencePetrowsky H, 2006, ANN SURG, V244, P921, DOI 10.1097/01.sla.0000246834.07130.5deng
hcfmusp.relation.referenceRacusen Lorraine C, 2004, Am J Transplant, V4, P1562, DOI 10.1111/j.1600-6143.2004.00585.xeng
hcfmusp.relation.referenceSasaki H, 1996, TRANSPLANT P, V28, P1908eng
hcfmusp.relation.referenceScheuer Peter J, 2002, Clin Liver Dis, V6, P335, DOI 10.1016/S1089-3261(02)00009-0eng
hcfmusp.relation.referenceTapuria N, 2009, HPB, V11, P108, DOI 10.1111/j.1477-2574.2009.00006.xeng
hcfmusp.relation.referenceTapuria N, 2008, J SURG RES, V150, P304, DOI 10.1016/j.jss.2007.12.747eng
hcfmusp.relation.reference[王成山 Wang Chengshan], 2014, [电工技术学报, Transactions of China Electrotechnical Society], V29, P1eng
hcfmusp.relation.referenceWeigand K, 2012, HPB SURG, V2012, P17672eng
hcfmusp.relation.referenceYadav SS, 1999, HEPATOLOGY, V30, P1223, DOI 10.1002/hep.510300513eng
hcfmusp.relation.referenceYan S, 2010, HEPATOB PANCREAT DIS, V9, P346eng
hcfmusp.scopus.lastupdate2024-06-14
relation.isAuthorOfPublicationa7349315-e358-43d1-ad81-16dee62d96e8
relation.isAuthorOfPublication6af04054-c85f-4b90-b417-af1c2dbab478
relation.isAuthorOfPublication0a8a2591-8b19-495a-acd3-bab58661acf1
relation.isAuthorOfPublication86c11757-5710-47bf-9e2b-cd6ee5a87d74
relation.isAuthorOfPublicationc99a7d1c-bd0d-472c-adf9-24e234620b5a
relation.isAuthorOfPublication44bbfe2e-509a-45f9-84af-652f129ae3dc
relation.isAuthorOfPublication1d894555-2ba1-4d5b-99e4-5cd8baab034a
relation.isAuthorOfPublication.latestForDiscoverya7349315-e358-43d1-ad81-16dee62d96e8
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_GOMES_Remote_Ischemic_Preconditioning_Is_Efficient_in_Reducing_Hepatic_2018.PDF
Tamanho:
1.06 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/26
Artigos e Materiais de Revistas Científicas - LIM/30